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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 14-FEB-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae ASP0581
  • locus tag: EL334_RS01880 [old locus tag: ASP0581_03490 ]
  • pan locus tag?: PNEUPAN001126000
  • symbol: EL334_RS01880
  • pan gene symbol?: cps2D
  • synonyms: cps4D, cpsD
  • product: tyrosine-protein kinase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: EL334_RS01880 [old locus tag: ASP0581_03490 ]
  • symbol: EL334_RS01880
  • product: tyrosine-protein kinase
  • replicon: chromosome
  • strand: +
  • coordinates: 333264..333938
  • length: 675
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_AP019192 (333264..333938) NCBI
  • BioCyc: EL334_RS01880 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0318 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    ATGCCAACATTAGAAATCTCACAGGCAAAATTGGATTTTGTAAAAAAGGCAGAGGAAAAT
    TATAACGCTTTGTGCACGAACCTACAGTTAAGTGGAGATGATTTGAAAGTATTTTCTATC
    ACTTCTGTAAAACAAGGAGAAGGAAAATCAACGACTTCCACCAATATCGCTTGGGCTTTT
    GCGCGTGCAGGTTACAAAACGCTGCTGATTGATGGAGATATTCGCAATTCTGTTATGTTA
    GGTGTCTTTAAAGCAAGAGATAAGATTACAGGCCTGACAGAATTTTTATCAGGAACTACA
    GACCTATCACAAGGGCTTTGTGATACGAATATCGAAAATCTCTTTGTAATTCAGGCTGGC
    TCTGTGTCACCGAATCCGACAGCTCTTCTTCAAAGTAAGAATTTCAGTACAATGCTTGAA
    ACCTTGCGTAAATATTTTGACTACATCATTGTAGATACTGCTCCTGTCGGTGTCGTGATT
    GATGCGGCTATTATTACGCAAAAATGCGATGCTTCTATTTTAGTGACGAAGGCAGGTGAA
    ATAAATCGACGGGATATTCAAAAAGCAAAAGAACAGTTGGAACACACAGGGAAGCCGTTT
    TTGGGAGTTGTGTTGAATAAATTCGATACTTCAGTAGACAAATACGGTTCTTATGGAAAT
    TACGGAAAAAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    675

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: EL334_RS01880 [old locus tag: ASP0581_03490 ]
  • symbol: EL334_RS01880
  • description: tyrosine-protein kinase
  • length: 224
  • theoretical pI: 8.01282
  • theoretical MW: 24493.8
  • GRAVY: -0.14375

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids capsular exopolysaccharide family (TIGR01007; HMM-score: 347.1)
    and 15 more
    chain length determinant protein tyrosine kinase EpsG (TIGR03029; HMM-score: 105.6)
    exopolysaccharide/PEP-CTERM locus tyrosine autokinase (TIGR03018; EC 2.7.10.2; HMM-score: 104.8)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids exopolysaccharide transport protein family (TIGR01005; HMM-score: 101.3)
    cell division ATPase MinD (TIGR01969; HMM-score: 68.1)
    Cellular processes Cellular processes Cell division septum site-determining protein MinD (TIGR01968; HMM-score: 63.2)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides cellulose synthase operon protein YhjQ (TIGR03371; HMM-score: 30)
    helicase/secretion neighborhood CpaE-like protein (TIGR03815; HMM-score: 27.9)
    Hypothetical proteins Conserved transport-energizing ATPase, TRC40/GET3/ArsA family (TIGR00345; EC 3.6.1.-; HMM-score: 26.3)
    Genetic information processing Mobile and extrachromosomal element functions Plasmid functions plasmid partitioning protein RepA (TIGR03453; HMM-score: 25.1)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Chlorophyll and bacteriochlorphyll light-independent protochlorophyllide reductase, iron-sulfur ATP-binding protein (TIGR01281; EC 1.3.7.7; HMM-score: 18.7)
    arsenical pump-driving ATPase (TIGR04291; EC 3.6.1.-; HMM-score: 17.8)
    Metabolism Central intermediary metabolism Nitrogen fixation nitrogenase iron protein (TIGR01287; EC 1.18.6.1; HMM-score: 13.4)
    signal recognition particle protein SRP54 (TIGR01425; HMM-score: 12.9)
    xanthine dehydrogenase E subunit (TIGR03198; EC 1.17.1.4; HMM-score: 12.3)
    ornithine--oxo-acid transaminase (TIGR01885; EC 2.6.1.13; HMM-score: 11.8)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    P-loop_NTPase (CL0023) AAA_31; AAA domain (PF13614; HMM-score: 57.6)
    CbiA; CobQ/CobB/MinD/ParA nucleotide binding domain (PF01656; HMM-score: 49.3)
    ParA; NUBPL iron-transfer P-loop NTPase (PF10609; HMM-score: 47.1)
    and 7 more
    MipZ; ATPase MipZ (PF09140; HMM-score: 24.1)
    ArsA_ATPase; Anion-transporting ATPase (PF02374; HMM-score: 22.6)
    CBP_BcsQ; Cellulose biosynthesis protein BcsQ (PF06564; HMM-score: 21.1)
    Fer4_NifH; 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family (PF00142; HMM-score: 17.2)
    SRP54; SRP54-type protein, GTPase domain (PF00448; HMM-score: 15.7)
    FTHFS; Formate--tetrahydrofolate ligase (PF01268; HMM-score: 13.6)
    no clan defined AFOR_N; Aldehyde ferredoxin oxidoreductase, N-terminal domain (PF02730; HMM-score: 12.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.17
    • Cytoplasmic Membrane Score: 9.51
    • Cellwall Score: 0.16
    • Extracellular Score: 0.15
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.782
    • Cytoplasmic Membrane Score: 0.1159
    • Cell wall & surface Score: 0.0009
    • Extracellular Score: 0.1011
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.027938
    • TAT(Tat/SPI): 0.001524
    • LIPO(Sec/SPII): 0.001389
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001142528 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MPTLEISQAKLDFVKKAEENYNALCTNLQLSGDDLKVFSITSVKQGEGKSTTSTNIAWAFARAGYKTLLIDGDIRNSVMLGVFKARDKITGLTEFLSGTTDLSQGLCDTNIENLFVIQAGSVSPNPTALLQSKNFSTMLETLRKYFDYIIVDTAPVGVVIDAAIITQKCDASILVTKAGEINRRDIQKAKEQLEHTGKPFLGVVLNKFDTSVDKYGSYGNYGKK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Judy K Morona, David C Miller, Renato Morona, James C Paton
The effect that mutations in the conserved capsular polysaccharide biosynthesis genes cpsA, cpsB, and cpsD have on virulence of Streptococcus pneumoniae.
J Infect Dis: 2004, 189(10);1905-13
[PubMed:15122528] [WorldCat.org] [DOI] (P p)

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