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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 02-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae ST556
  • locus tag: MYY_RS02215 [old locus tag: MYY_0429 ]
  • pan locus tag?: PNEUPAN001126000
  • symbol: cpsD
  • pan gene symbol?: cps2D
  • synonym: cps4D
  • product: polysaccharide biosynthesis tyrosine autokinase CpsD

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: MYY_RS02215 [old locus tag: MYY_0429 ]
  • symbol: cpsD
  • product: polysaccharide biosynthesis tyrosine autokinase CpsD
  • replicon: chromosome
  • strand: +
  • coordinates: 398321..399004
  • length: 684
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_017769 (398321..399004) NCBI
  • BioCyc: MYY_RS02215 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0318 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    ATGCCGACATTAGAAATAGCACAAAAAAAACTGGAGTTCGTTAAGAAGGCAGAAGAATAT
    TACAATGCCTTGTGTACAAATATACAGTTGAGCGGAGATAAACTAAAAGTAATTTCCGTT
    ACTTCTGTTAACCCTGGGGAAGGAAAAACAACTACTTCCGTAAATATAGCAAGGTCGTTT
    GCGCGTGCAGGCTATAAAACTCTTTTGATCGATGGCGATATTCGAAATTCAGTTATGTCA
    GGATTTTTTAAATCTCGTGAAAAAATTACAGGGCTAACGGAATTTTTATCTGGGACAGCT
    GATTTATCTCACGGTTTATGTGATACAAATATTGAAAATTTATTTGTAGTTCAATCGGGC
    ACTGTATCACCAAACCCTACAGCCTTGTTACAAAGTAAAAATTTTAATGATATGATTGAA
    ACATTGCGTAAATATTTTGATTATATAATTGTTGATACAGCACCTATTGGAATTGTTATT
    GATGCGGCAATTATCACTCAAAAGTGTGATGCGTCCATCTTGGTAACAGCAACAGGTGAG
    GTGAATAAACGTGATGTCCAAAAAGCGAAACAACAATTAGAACAAACAGGGAAACTGTTC
    CTAGGAGTTGTTTTTAATAAATTAGATATCTCGGTTGATAAGTATGGAGTTTACGGTTTC
    TATGGAAATTATGGTAAAAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    684

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: MYY_RS02215 [old locus tag: MYY_0429 ]
  • symbol: CpsD
  • description: polysaccharide biosynthesis tyrosine autokinase CpsD
  • length: 227
  • theoretical pI: 8.72921
  • theoretical MW: 24946.5
  • GRAVY: -0.103524

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.10.2?  ExPASy
    Non-specific protein-tyrosine kinase ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
  • TIGRFAM:
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids capsular exopolysaccharide family (TIGR01007; HMM-score: 343.5)
    and 14 more
    exopolysaccharide/PEP-CTERM locus tyrosine autokinase (TIGR03018; EC 2.7.10.2; HMM-score: 108.2)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids exopolysaccharide transport protein family (TIGR01005; HMM-score: 107.7)
    chain length determinant protein tyrosine kinase EpsG (TIGR03029; HMM-score: 100.6)
    cell division ATPase MinD (TIGR01969; HMM-score: 68.9)
    Cellular processes Cellular processes Cell division septum site-determining protein MinD (TIGR01968; HMM-score: 58.9)
    Genetic information processing Mobile and extrachromosomal element functions Plasmid functions plasmid partitioning protein RepA (TIGR03453; HMM-score: 35.4)
    Hypothetical proteins Conserved transport-energizing ATPase, TRC40/GET3/ArsA family (TIGR00345; EC 3.6.1.-; HMM-score: 26.5)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides cellulose synthase operon protein YhjQ (TIGR03371; HMM-score: 26.2)
    helicase/secretion neighborhood CpaE-like protein (TIGR03815; HMM-score: 24)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking signal recognition particle-docking protein FtsY (TIGR00064; HMM-score: 20.3)
    arsenical pump-driving ATPase (TIGR04291; EC 3.6.1.-; HMM-score: 16.5)
    Metabolism Central intermediary metabolism Sulfur metabolism adenylyl-sulfate kinase (TIGR00455; EC 2.7.1.25; HMM-score: 13)
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan UDP-N-acetylmuramyl-tripeptide synthetase (TIGR01085; HMM-score: 12.7)
    Genetic information processing Mobile and extrachromosomal element functions Prophage functions phage replicative helicase, DnaB family (TIGR03600; HMM-score: 11.3)
  • TheSEED: see MYY_0429
  • PFAM:
    P-loop_NTPase (CL0023) AAA_31; AAA domain (PF13614; HMM-score: 61.8)
    and 10 more
    CbiA; CobQ/CobB/MinD/ParA nucleotide binding domain (PF01656; HMM-score: 45.8)
    ParA; NUBPL iron-transfer P-loop NTPase (PF10609; HMM-score: 42.1)
    MipZ; ATPase MipZ (PF09140; HMM-score: 26.8)
    ArsA_ATPase; Anion-transporting ATPase (PF02374; HMM-score: 21.1)
    SRP54; SRP54-type protein, GTPase domain (PF00448; HMM-score: 17.4)
    FTHFS; Formate--tetrahydrofolate ligase (PF01268; HMM-score: 16.8)
    CBP_BcsQ; Cellulose biosynthesis protein BcsQ (PF06564; HMM-score: 16.5)
    MeaB; Methylmalonyl Co-A mutase-associated GTPase MeaB (PF03308; HMM-score: 14.6)
    TIM_barrel (CL0036) QRPTase_C; Quinolinate phosphoribosyl transferase, C-terminal domain (PF01729; HMM-score: 13.7)
    P-loop_NTPase (CL0023) AAA_26; AAA domain (PF13500; HMM-score: 12.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 1.05
    • Cytoplasmic Membrane Score: 8.78
    • Cellwall Score: 0.08
    • Extracellular Score: 0.09
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.6942
    • Cytoplasmic Membrane Score: 0.0986
    • Cell wall & surface Score: 0.0007
    • Extracellular Score: 0.2066
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.016014
    • TAT(Tat/SPI): 0.001592
    • LIPO(Sec/SPII): 0.002113
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001142521 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MPTLEIAQKKLEFVKKAEEYYNALCTNIQLSGDKLKVISVTSVNPGEGKTTTSVNIARSFARAGYKTLLIDGDIRNSVMSGFFKSREKITGLTEFLSGTADLSHGLCDTNIENLFVVQSGTVSPNPTALLQSKNFNDMIETLRKYFDYIIVDTAPIGIVIDAAIITQKCDASILVTATGEVNKRDVQKAKQQLEQTGKLFLGVVFNKLDISVDKYGVYGFYGNYGKK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Judy K Morona, David C Miller, Renato Morona, James C Paton
The effect that mutations in the conserved capsular polysaccharide biosynthesis genes cpsA, cpsB, and cpsD have on virulence of Streptococcus pneumoniae.
J Infect Dis: 2004, 189(10);1905-13
[PubMed:15122528] [WorldCat.org] [DOI] (P p)

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