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serotype 4
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serotype 19A
Hu17
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serotype 1
INV200
serotype 14
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serotype 1
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SPN994038
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SPNA45
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ST556
serotype 19F
TCH8431/19A
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serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 28-AUG-2013

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TCH8431/19A
  • locus tag: HMPREF0837_11172 [new locus tag: HMPREF0837_RS05615 ]
  • pan locus tag?: PNEUPAN002652000
  • symbol: aroE
  • pan gene symbol?: aroE
  • synonym:
  • product: shikimate dehydrogenase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HMPREF0837_11172 [new locus tag: HMPREF0837_RS05615 ]
  • symbol: aroE
  • product: shikimate dehydrogenase
  • replicon: chromosome
  • strand: +
  • coordinates: 1069654..1070508
  • length: 855
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    ATGAAGCTTGATGGCTATACACGTTTAGCTGCAGTTGTTGCCAATCCTATTAAGCATTCT
    ATTTCTCCCTTCATCCACAATAGAGCCTTTGAGGCGACAGCTACCAACGGTGCTTATGTG
    GCTTGGGAGATTGAAGCGAGTGACTTGGCAGAAACAGTGGCCAATATTCGTCGCTACCAG
    ATGTTTGGCATCAATCTGTCCATGCCCTATAAGGAGCAGGTGATTCCTTATTTGGATAAG
    CTGAGCGATGAAGCGCGCTTGATTGGTGCGGTTAATACGGTTGTCAATGAGAATGGCAAT
    TTAATTGGATATAATACAGATGGCAAGGGATTTTTTAAGTGCTTGCCTTCTTTTACAATT
    TCAGGTAAAAAGATGACCCTGCTGGGTGCAGGTGGTGCGGCTAAATCAATCTTGGCACAG
    GCTATTTTGGATGGCGTCAGTCAGATTTCGGTCTTTGTTCGTTCAGTTTCTATGGAAAAA
    ACAAGACCTTACCTAGACAAGTTACAGGAGCAAACAGGCTTTAAAGTGGACTTGTATGCT
    TTAGAAAATGTTTCTGAACTGCAAGCAAGGATTGTCGAGTCGGATTTACTGGTCAATGCC
    ACCAGTGTGGGCATGGATGGTCAATCATCCCCAGTTCCTGAAAGCATCAATTTGCCAGAA
    ACTATCTTGGTGGCAGATATTATTTATCAACCCTTTGAAACGCCATTTTTAAAATGGGCC
    AGAAGTCAGGGCAAACCAGCGGTTAATGGTCTGGGAATGTTGCTCTATCAAGCTGCAGAA
    GCTTTTCAACTGTGGACAGGCAAGGAAATGCCAACAGAAGAGATTTGGCAGTCTTTAACA
    GAAAAATACCAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    855

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HMPREF0837_11172 [new locus tag: HMPREF0837_RS05615 ]
  • symbol: AroE
  • description: shikimate dehydrogenase
  • length: 284
  • theoretical pI: 4.86662
  • theoretical MW: 31282.6
  • GRAVY: -0.0588028

⊟Function[edit | edit source]

  • reaction:
    EC 1.1.1.25?  ExPASy
    Shikimate dehydrogenase Shikimate + NADP+ = 3-dehydroshikimate + NADPH
  • TIGRFAM:
    Metabolism Amino acid biosynthesis Aromatic amino acid family shikimate dehydrogenase (TIGR00507; EC 1.1.1.25; HMM-score: 238)
    and 3 more
    Metabolism Amino acid biosynthesis Aromatic amino acid family shikimate-5-dehydrogenase (TIGR01809; EC 1.1.1.25; HMM-score: 116.9)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin glutamyl-tRNA reductase (TIGR01035; EC 1.2.1.70; HMM-score: 12.6)
    Genetic information processing Protein synthesis Ribosomal proteins: synthesis and modification ribosomal protein uS11 (TIGR03632; HMM-score: 12.3)
  • TheSEED  :
    • Shikimate/quinate 5-dehydrogenase I beta (EC 1.1.1.282)
    Amino Acids and Derivatives Aromatic amino acids and derivatives Chorismate Synthesis  Shikimate/quinate 5-dehydrogenase I beta (EC 1.1.1.282)
    and 2 more
    Amino Acids and Derivatives Aromatic amino acids and derivatives Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate)  Shikimate/quinate 5-dehydrogenase I beta (EC 1.1.1.282)
    Metabolism of Aromatic Compounds Peripheral pathways for catabolism of aromatic compounds Quinate degradation  Shikimate/quinate 5-dehydrogenase I beta (EC 1.1.1.282)
  • PFAM:
    AA_dh_N (CL0603) Shikimate_dh_N; Shikimate dehydrogenase substrate binding domain (PF08501; HMM-score: 97)
    and 3 more
    no clan defined SDH_C; Shikimate 5'-dehydrogenase C-terminal domain (PF18317; HMM-score: 50.9)
    NADP_Rossmann (CL0063) Shikimate_DH; Shikimate / quinate 5-dehydrogenase (PF01488; HMM-score: 19.9)
    P-loop_NTPase (CL0023) TsaE; Threonylcarbamoyl adenosine biosynthesis protein TsaE (PF02367; HMM-score: 13.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9973
    • Cytoplasmic Membrane Score: 0.0004
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0023
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.019743
    • TAT(Tat/SPI): 0.002814
    • LIPO(Sec/SPII): 0.001642
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ADI69400 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKLDGYTRLAAVVANPIKHSISPFIHNRAFEATATNGAYVAWEIEASDLAETVANIRRYQMFGINLSMPYKEQVIPYLDKLSDEARLIGAVNTVVNENGNLIGYNTDGKGFFKCLPSFTISGKKMTLLGAGGAAKSILAQAILDGVSQISVFVRSVSMEKTRPYLDKLQEQTGFKVDLYALENVSELQARIVESDLLVNATSVGMDGQSSPVPESINLPETILVADIIYQPFETPFLKWARSQGKPAVNGLGMLLYQAAEAFQLWTGKEMPTEEIWQSLTEKYQ

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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