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serotype 4
D39
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D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
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A66
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AP200
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ASP0581
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ATCC 49619
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ATCC 700669
serotype 23F
BM6001
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BVJ1JL
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CGSP14
serotype 14
G54
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HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 28-AUG-2013

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TCH8431/19A
  • locus tag: HMPREF0837_11915 [new locus tag: HMPREF0837_RS09165 ]
  • pan locus tag?: PNEUPAN003089000
  • symbol: HMPREF0837_11915
  • pan gene symbol?: pbp2b
  • synonym:
  • product: penicillin-binding protein, transpeptidase domain protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HMPREF0837_11915 [new locus tag: HMPREF0837_RS09165 ]
  • symbol: HMPREF0837_11915
  • product: penicillin-binding protein, transpeptidase domain protein
  • replicon: chromosome
  • strand: -
  • coordinates: 1754996..1756966
  • length: 1971
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    ATGACCATTATTGGTCGTTTGTTGTATATGCAGGTTTTGAACAAGGATTTTTACGAAAAA
    AAGCTAGCCTCAGCTAGTCAGACCAAGGTCACAACCAGTTCTGCTCGTGGGGAAATCTAT
    GATGCTAGTGGAAAACCTTTGGTAGAAAATACGTTAAAGCAGGTTGTTTCCTTTACGCGT
    AGCAATAAAATGACGGCTACAGACTTAAAAGAAATAGCTAAAAAGTTACTGACTTATGTG
    AGCATCAGTTCGCCAAATTTGACAGAACGCCAGCTGGCTGATTACTATTTGGCTGATCCT
    GAAATCTATAAAAAAACAGTGGAAGCTCTCCCAAGTGAGAAACGATTGGATTCAGATGGC
    AATCGCCTATCCGAATCAGAACTGTATAACAATGCGGTCGATAGTGTCCCAACAAGTCAA
    CTAAACTATACAGAGGATGAAAAGAAAGAAATCTATCTTTTTAGTCAGTTAAATGCTGTT
    GGAAACTTTGCGACAGGAACCATTGCGACAGATCCTCTAAATGATTCTCAGGTGGCTGTT
    ATTGCCTCTATTTCAAAGGAGATGCCTGGCATTAGTATTTCTACTTCTTGGGATAGAAAG
    GTTTTAGAAACCTCTCTTTCTTCTATAGTAGGTAGTGTATCCAGTGAAAAAGCTGGTCTC
    CCAGCGGAAGAAGTGGATACCTATCTTAAAAAAGGTTATTCTCTAAATGATCGTGTTGGA
    ACCTCCTATTTGGAAAAGCAATATGAAGAGACCTTACAAGGGAAACGCTCGGTAAAAGAA
    ATCCATCTGGATAAATATGGCAACATGGAAAGTGTGGATACAATTGAGGAAGGTAGTAAG
    GGAAACAATATCAAACTGACCATTGATTTGGCCTTTCAAGATAGTGTGGATGCTTTGTTG
    AAAAGTTATTTCAATTCCGAGCTAGGAAATGGGGGAGCCAAGTATTCTGAGGGTGTTTAT
    GCAGTTGCTTTGAATCCCAAAACAGGTGCGGTTTTGTCTATGTCAGGGCTCAAACATGAC
    CTGAACACGGGAGAGTTGACTCCTGATTCCTTGGGAACGGTAACCAATGTCTTTGTCCCA
    GGGTCAGTAGTTAAGGCCGCTACCATCAGCTCAGGTTGGGAAAATGGTGTTTTATCAGGA
    AACCAAACCTTAACAGATCAGCCTATTGTTTTCCAAGGTTCAGCTCCAATTTATTCTTGG
    TATAAATTGGCATATGGATCTTTTCCTATTACAGCTGTGGAAGCCTTGGAGTATTCATCT
    AATGCTTACATGGTTCAAACCGCTCTTGGAATCATGGGCCAGACCTATCAACCAAATATG
    TTTGTTGGAACCAGCAATTTGGAAACAGCTATGGGAAAACTTCGTGCGACCTTTGGCGAA
    TATGGCTTGGGGGCTGCGACCGGAATTGACCTACCAGATGAATCTACTGGATTTGTTCCC
    AAAGAGTATAGCTTTGCTAATTACATCACCAATGCCTTTGGGCAGTTTGATAACTATACG
    CCCATGCAGTTGGCTCAGTATGTAGCAACTATTGCAAATGATGGTGTTCGTGTGGCTCCT
    CGTATTGTTGAAGGTATTTATGGAAATAATGATAAGGGTGGCCTTGGGGAATTAATCCAA
    GCAATAGATACCAAGGAAATCAACAAGGTCAATATTTCTGAATCAGATATGGCAATCTTG
    CACCAAGGATTTTACCAAGTATCGCATGGAACTAGTCCCCTTACGACAGGACGGGCGTTT
    TCAGATGGCGCCACTGTTTCTATCAGTGGTAAGACCGGTACAGGTGAAAGCTATGTAGCT
    GGTGGTCAAGAAGCTAATAATACCAATGCCGTGGCCTATGCTCCAACAGAAAATCCTCAA
    ATTGCAGTTGCAGTAGTCTTTCCTCATAATACCAATTTAACCAAAAATGTTGGGCCAGCA
    ATTGCTCGCGACATTATCAATTTATATAACCAACACCATCCAATGAATTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1971

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HMPREF0837_11915 [new locus tag: HMPREF0837_RS09165 ]
  • symbol: HMPREF0837_11915
  • description: penicillin-binding protein, transpeptidase domain protein
  • length: 656
  • theoretical pI: 4.68521
  • theoretical MW: 70868.8
  • GRAVY: -0.275305

⊟Function[edit | edit source]

  • TIGRFAM:
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan penicillin-binding protein 2 (TIGR03423; HMM-score: 207.6)
    and 3 more
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan stage V sporulation protein D (TIGR02214; HMM-score: 113.2)
    Cellular processes Cellular processes Sporulation and germination stage V sporulation protein D (TIGR02214; HMM-score: 113.2)
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan penicillin-binding protein, 1A family (TIGR02074; HMM-score: 46.1)
  • TheSEED  :
    • Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129)
    Cell Division and Cell Cycle Cell Division and Cell Cycle - no subcategory Bacterial Cytoskeleton  Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129)
    and 1 more
    Cell Wall and Capsule Cell Wall and Capsule - no subcategory Peptidoglycan Biosynthesis  Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129)
  • PFAM:
    Beta-lactamase (CL0013) Transpeptidase; Penicillin binding protein transpeptidase domain (PF00905; HMM-score: 245.4)
    and 1 more
    no clan defined PBP_dimer; Penicillin-binding Protein dimerisation domain (PF03717; HMM-score: 122.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.17
    • Cytoplasmic Membrane Score: 9.51
    • Cellwall Score: 0.16
    • Extracellular Score: 0.15
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0005
    • Cytoplasmic Membrane Score: 0.74
    • Cell wall & surface Score: 0.0093
    • Extracellular Score: 0.2502
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.018312
    • TAT(Tat/SPI): 0.002104
    • LIPO(Sec/SPII): 0.001911
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ADI70143 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MTIIGRLLYMQVLNKDFYEKKLASASQTKVTTSSARGEIYDASGKPLVENTLKQVVSFTRSNKMTATDLKEIAKKLLTYVSISSPNLTERQLADYYLADPEIYKKTVEALPSEKRLDSDGNRLSESELYNNAVDSVPTSQLNYTEDEKKEIYLFSQLNAVGNFATGTIATDPLNDSQVAVIASISKEMPGISISTSWDRKVLETSLSSIVGSVSSEKAGLPAEEVDTYLKKGYSLNDRVGTSYLEKQYEETLQGKRSVKEIHLDKYGNMESVDTIEEGSKGNNIKLTIDLAFQDSVDALLKSYFNSELGNGGAKYSEGVYAVALNPKTGAVLSMSGLKHDLNTGELTPDSLGTVTNVFVPGSVVKAATISSGWENGVLSGNQTLTDQPIVFQGSAPIYSWYKLAYGSFPITAVEALEYSSNAYMVQTALGIMGQTYQPNMFVGTSNLETAMGKLRATFGEYGLGAATGIDLPDESTGFVPKEYSFANYITNAFGQFDNYTPMQLAQYVATIANDGVRVAPRIVEGIYGNNDKGGLGELIQAIDTKEINKVNISESDMAILHQGFYQVSHGTSPLTTGRAFSDGATVSISGKTGTGESYVAGGQEANNTNAVAYAPTENPQIAVAVVFPHNTNLTKNVGPAIARDIINLYNQHHPMN

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

R Hakenbeck, C Martin, C Dowson, T Grebe
Penicillin-binding protein 2b of Streptococcus pneumoniae in piperacillin-resistant laboratory mutants.
J Bacteriol: 1994, 176(17);5574-7
[PubMed:8071243] [WorldCat.org] [DOI] (P p)

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