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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 25-OCT-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TCH8431/19A
  • locus tag: HMPREF0837_RS09165 [old locus tag: HMPREF0837_11915 ]
  • pan locus tag?: PNEUPAN003089000
  • symbol: pbp2b
  • pan gene symbol?: pbp2b
  • synonym:
  • product: penicillin-binding protein PBP2B

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HMPREF0837_RS09165 [old locus tag: HMPREF0837_11915 ]
  • symbol: pbp2b
  • product: penicillin-binding protein PBP2B
  • replicon: chromosome
  • strand: -
  • coordinates: 1754996..1757053
  • length: 2058
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: NC_014251 (1754996..1757053) NCBI
  • BioCyc: HMPREF0837_RS09165 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1486 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    ATGAGACTGATTTGTATGAGAAAATTTAACAGCCATTCGATTCCGATTCGGCTTAATTTA
    TTGTTTTCAATCGTCATTTTACTCTTTATGACCATTATTGGTCGTTTGTTGTATATGCAG
    GTTTTGAACAAGGATTTTTACGAAAAAAAGCTAGCCTCAGCTAGTCAGACCAAGGTCACA
    ACCAGTTCTGCTCGTGGGGAAATCTATGATGCTAGTGGAAAACCTTTGGTAGAAAATACG
    TTAAAGCAGGTTGTTTCCTTTACGCGTAGCAATAAAATGACGGCTACAGACTTAAAAGAA
    ATAGCTAAAAAGTTACTGACTTATGTGAGCATCAGTTCGCCAAATTTGACAGAACGCCAG
    CTGGCTGATTACTATTTGGCTGATCCTGAAATCTATAAAAAAACAGTGGAAGCTCTCCCA
    AGTGAGAAACGATTGGATTCAGATGGCAATCGCCTATCCGAATCAGAACTGTATAACAAT
    GCGGTCGATAGTGTCCCAACAAGTCAACTAAACTATACAGAGGATGAAAAGAAAGAAATC
    TATCTTTTTAGTCAGTTAAATGCTGTTGGAAACTTTGCGACAGGAACCATTGCGACAGAT
    CCTCTAAATGATTCTCAGGTGGCTGTTATTGCCTCTATTTCAAAGGAGATGCCTGGCATT
    AGTATTTCTACTTCTTGGGATAGAAAGGTTTTAGAAACCTCTCTTTCTTCTATAGTAGGT
    AGTGTATCCAGTGAAAAAGCTGGTCTCCCAGCGGAAGAAGTGGATACCTATCTTAAAAAA
    GGTTATTCTCTAAATGATCGTGTTGGAACCTCCTATTTGGAAAAGCAATATGAAGAGACC
    TTACAAGGGAAACGCTCGGTAAAAGAAATCCATCTGGATAAATATGGCAACATGGAAAGT
    GTGGATACAATTGAGGAAGGTAGTAAGGGAAACAATATCAAACTGACCATTGATTTGGCC
    TTTCAAGATAGTGTGGATGCTTTGTTGAAAAGTTATTTCAATTCCGAGCTAGGAAATGGG
    GGAGCCAAGTATTCTGAGGGTGTTTATGCAGTTGCTTTGAATCCCAAAACAGGTGCGGTT
    TTGTCTATGTCAGGGCTCAAACATGACCTGAACACGGGAGAGTTGACTCCTGATTCCTTG
    GGAACGGTAACCAATGTCTTTGTCCCAGGGTCAGTAGTTAAGGCCGCTACCATCAGCTCA
    GGTTGGGAAAATGGTGTTTTATCAGGAAACCAAACCTTAACAGATCAGCCTATTGTTTTC
    CAAGGTTCAGCTCCAATTTATTCTTGGTATAAATTGGCATATGGATCTTTTCCTATTACA
    GCTGTGGAAGCCTTGGAGTATTCATCTAATGCTTACATGGTTCAAACCGCTCTTGGAATC
    ATGGGCCAGACCTATCAACCAAATATGTTTGTTGGAACCAGCAATTTGGAAACAGCTATG
    GGAAAACTTCGTGCGACCTTTGGCGAATATGGCTTGGGGGCTGCGACCGGAATTGACCTA
    CCAGATGAATCTACTGGATTTGTTCCCAAAGAGTATAGCTTTGCTAATTACATCACCAAT
    GCCTTTGGGCAGTTTGATAACTATACGCCCATGCAGTTGGCTCAGTATGTAGCAACTATT
    GCAAATGATGGTGTTCGTGTGGCTCCTCGTATTGTTGAAGGTATTTATGGAAATAATGAT
    AAGGGTGGCCTTGGGGAATTAATCCAAGCAATAGATACCAAGGAAATCAACAAGGTCAAT
    ATTTCTGAATCAGATATGGCAATCTTGCACCAAGGATTTTACCAAGTATCGCATGGAACT
    AGTCCCCTTACGACAGGACGGGCGTTTTCAGATGGCGCCACTGTTTCTATCAGTGGTAAG
    ACCGGTACAGGTGAAAGCTATGTAGCTGGTGGTCAAGAAGCTAATAATACCAATGCCGTG
    GCCTATGCTCCAACAGAAAATCCTCAAATTGCAGTTGCAGTAGTCTTTCCTCATAATACC
    AATTTAACCAAAAATGTTGGGCCAGCAATTGCTCGCGACATTATCAATTTATATAACCAA
    CACCATCCAATGAATTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2058

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HMPREF0837_RS09165 [old locus tag: HMPREF0837_11915 ]
  • symbol: Pbp2b
  • description: penicillin-binding protein PBP2B
  • length: 685
  • theoretical pI: 4.92365
  • theoretical MW: 74340.1
  • GRAVY: -0.216058

⊟Function[edit | edit source]

  • TIGRFAM:
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan penicillin-binding protein 2 (TIGR03423; HMM-score: 217.9)
    and 3 more
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan stage V sporulation protein D (TIGR02214; HMM-score: 121.1)
    Cellular processes Cellular processes Sporulation and germination stage V sporulation protein D (TIGR02214; HMM-score: 121.1)
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan penicillin-binding protein, 1A family (TIGR02074; HMM-score: 45.9)
  • TheSEED: see HMPREF0837_11915
  • PFAM:
    Beta-lactamase (CL0013) Transpeptidase; Penicillin binding protein transpeptidase domain (PF00905; HMM-score: 245.2)
    and 2 more
    no clan defined PBP_dimer; Penicillin-binding Protein dimerisation domain (PF03717; HMM-score: 122.8)
    ABC-2 (CL0181) ABC_export; Putative ABC exporter (PF16962; HMM-score: 11.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.17
    • Cytoplasmic Membrane Score: 9.51
    • Cellwall Score: 0.16
    • Extracellular Score: 0.15
    • Internal Helix: 1
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0.9826
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.0172
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.03571
    • TAT(Tat/SPI): 0.000415
    • LIPO(Sec/SPII): 0.005
  • predicted transmembrane helices (TMHMM): 1

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_073078393 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MRLICMRKFNSHSIPIRLNLLFSIVILLFMTIIGRLLYMQVLNKDFYEKKLASASQTKVTTSSARGEIYDASGKPLVENTLKQVVSFTRSNKMTATDLKEIAKKLLTYVSISSPNLTERQLADYYLADPEIYKKTVEALPSEKRLDSDGNRLSESELYNNAVDSVPTSQLNYTEDEKKEIYLFSQLNAVGNFATGTIATDPLNDSQVAVIASISKEMPGISISTSWDRKVLETSLSSIVGSVSSEKAGLPAEEVDTYLKKGYSLNDRVGTSYLEKQYEETLQGKRSVKEIHLDKYGNMESVDTIEEGSKGNNIKLTIDLAFQDSVDALLKSYFNSELGNGGAKYSEGVYAVALNPKTGAVLSMSGLKHDLNTGELTPDSLGTVTNVFVPGSVVKAATISSGWENGVLSGNQTLTDQPIVFQGSAPIYSWYKLAYGSFPITAVEALEYSSNAYMVQTALGIMGQTYQPNMFVGTSNLETAMGKLRATFGEYGLGAATGIDLPDESTGFVPKEYSFANYITNAFGQFDNYTPMQLAQYVATIANDGVRVAPRIVEGIYGNNDKGGLGELIQAIDTKEINKVNISESDMAILHQGFYQVSHGTSPLTTGRAFSDGATVSISGKTGTGESYVAGGQEANNTNAVAYAPTENPQIAVAVVFPHNTNLTKNVGPAIARDIINLYNQHHPMN

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

R Hakenbeck, C Martin, C Dowson, T Grebe
Penicillin-binding protein 2b of Streptococcus pneumoniae in piperacillin-resistant laboratory mutants.
J Bacteriol: 1994, 176(17);5574-7
[PubMed:8071243] [WorldCat.org] [DOI] (P p)

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