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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 25-OCT-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TCH8431/19A
  • locus tag: HMPREF0837_RS11195 [old locus tag: HMPREF0837_10197 ]
  • pan locus tag?: PNEUPAN003895000
  • symbol: pspC
  • pan gene symbol?: pspC
  • synonym:
  • product: pneumococcal surface protein PspC, LPXTG-anchored form

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HMPREF0837_RS11195 [old locus tag: HMPREF0837_10197 ]
  • symbol: pspC
  • product: pneumococcal surface protein PspC, LPXTG-anchored form
  • replicon: chromosome
  • strand: -
  • coordinates: 192646..194229
  • length: 1584
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_014251 (192646..194229) NCBI
  • BioCyc: HMPREF0837_RS11195 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    ATGTTTAAATCAAATCATGAGCGAAGAATGCGTTATTCCATTCGTAAATTTAGTGTAGGA
    GTAGCTAGCGTAGCTGTTGCCAGTCTTTTTATGGGAAGTGTTGTACATGCGACAGAGAAA
    GAGGGAAGTACCCAAGCAGCCACTTCTTTTAATAGGGGAAATGGAAGTCAGGCAGAACAA
    CGTGGAGAACTCGATTTAGAACGAGATAAGGCAATGAAAGCGGTCAGTGAATATGTAGGA
    AAAATGGTGAGAGATGCCTATGTAAAATCAGATAGAAAACGACATAAAAATACTGTAGCT
    CTAGTTAACCAGTTGGGAAACATTAAGAACAGGTATTTGAATGAAATAGTTCATTCAACC
    TCAAAAAGCCAACTACAGGAACTGATGATGAAGAGTCAATCAGAAGTAGATGAAGCTGTG
    TCTAAATTTGAAAAGGACTCATTTTCTTCGTCAAGTTCAGGATCCTCCACTAAACCAGAA
    ACTCCGCAGCCGGAAAATCCAGAGCATCAAAAACCAACAACTCCAGCTCCGGATACCAAA
    CCAAGCCCTCAACCAGAAGGCAAGAAACCAAGCGTACCAGACATTAATCAGGAAAAAGAA
    AAAGCTAAGCTTGCTGTAGCAACCTACATGAGCAAGATTTTAGATGATATACAAAAACAT
    CATCTGCAGAAAGAAAAACATCGTCAGATTGTTGCTCTTATTAAGGAGCTTGATGAGCTT
    AAAAAGCAAGCTCTTTCTGAAATTGATAATGTAAATACCAAAGTAGAAATTGAAAATACA
    GTCCACAAGATATTTGCAGACATGGATGCAGTTGTGACTAAATTCAAAAAAGGCTTAACT
    CAGGACACACCAAAAGAACCAGGTAACAAAAAACCATCTGCTCCAAAACCAGGTATGCAA
    CCAAGTCCTCAACCAGAGGTTAAACCGCAGCTAGAAAAACCAAAACCAGAGGTTAAACCG
    CAGCTGGAAAAACCAAAACCAGAGGTTAAACCGCAGCTGGAAAAACCAAAACCAGAGGTT
    AAACCGCAGCTGGAAAAACCAAAACCAGAGGTTAAACCGCAGCTGGAAAAACCAAAACCA
    GAGGTTAAACCGCAGCTGGAAAAACCGAAACCAGAGGTTAAACCGCAGCTGGAAAAACCG
    AAACCAGAGGTTAAACCGCAGCTGGAAAAACCAAAACCAGAGGTTAAACCGCAGCTGGAA
    AAACCAAAACCAGAGGTTAAACCGCAGCTGGAAAAACCAAAACCAGAGGTTAAACCGCAG
    CTGGAAAAACCAAAACCAGAGGTTAAACCGCAGCTGGAAAAACCAAAACCAGAGGTTAAA
    CCGCAGCTGGAAAAACCAAAACCAGAGGTTAAACCGCAGCTGGAAAAACCAAAACCAGAG
    GTTAAACCGCAGCTGGAAAAACCAAAACCAGAGGTTAAACCGCAGCTAGAAAAACCAAAA
    CCAGAGGTTAAACCGCAGCTGGAAAAACCAAAACCAGAGGTTAAACCGCAGCTGGAAAAA
    CCAAAACCAGAGGTTAAACCGCAGCTGGAAAAACCAAAACCAGAGGTTAAACCGCAGCTA
    GAAAAACCAAAACCAGAGGTTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1584

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HMPREF0837_RS11195 [old locus tag: HMPREF0837_10197 ]
  • symbol: PspC
  • description: pneumococcal surface protein PspC, LPXTG-anchored form
  • length: 527
  • theoretical pI: 10.3298
  • theoretical MW: 59707.8
  • GRAVY: -1.24459

⊟Function[edit | edit source]

  • TIGRFAM:
    gram-positive signal peptide, YSIRK family (TIGR01168; HMM-score: 60.4)
    and 3 more
    Cellular processes Cellular processes Pathogenesis type VI secretion-associated protein, VC_A0119 family (TIGR03362; HMM-score: 13.4)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type VI secretion-associated protein, VC_A0119 family (TIGR03362; HMM-score: 13.4)
    GeoRSP system SPASM domain protein (TIGR04304; HMM-score: 12.1)
  • TheSEED: see HMPREF0837_10197
  • PFAM:
    no clan defined RICH; RICH domain (PF05062; HMM-score: 165.2)
    and 5 more
    YSIRK_signal; YSIRK type signal peptide (PF04650; HMM-score: 46.8)
    EDD (CL0245) Dak1; Dak1 domain (PF02733; HMM-score: 16.1)
    B_GA (CL0598) DUF1542; Domain of Unknown Function (DUF1542) (PF07564; HMM-score: 15.1)
    EFTPs (CL0575) Ribosomal_L35Ae; Ribosomal protein L35Ae (PF01247; HMM-score: 14.3)
    Phospoesterase (CL0171) FBPase_glpX; Bacterial fructose-1,6-bisphosphatase, glpX-encoded (PF03320; HMM-score: 11.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helix: 1
  • DeepLocPro: Cell wall & surface
    • Cytoplasmic Score: 0.014
    • Cytoplasmic Membrane Score: 0.0005
    • Cell wall & surface Score: 0.8344
    • Extracellular Score: 0.1511
  • SignalP: Signal peptide SP(Sec/SPI) length 37 aa
    • SP(Sec/SPI): 0.962543
    • TAT(Tat/SPI): 0.028766
    • LIPO(Sec/SPII): 0.003054
    • Cleavage Site: CS pos: 37-38. VHA-TE. Pr: 0.9041
  • predicted transmembrane helices (TMHMM): 1

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000477094 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MFKSNHERRMRYSIRKFSVGVASVAVASLFMGSVVHATEKEGSTQAATSFNRGNGSQAEQRGELDLERDKAMKAVSEYVGKMVRDAYVKSDRKRHKNTVALVNQLGNIKNRYLNEIVHSTSKSQLQELMMKSQSEVDEAVSKFEKDSFSSSSSGSSTKPETPQPENPEHQKPTTPAPDTKPSPQPEGKKPSVPDINQEKEKAKLAVATYMSKILDDIQKHHLQKEKHRQIVALIKELDELKKQALSEIDNVNTKVEIENTVHKIFADMDAVVTKFKKGLTQDTPKEPGNKKPSAPKPGMQPSPQPEVKPQLEKPKPEVKPQLEKPKPEVKPQLEKPKPEVKPQLEKPKPEVKPQLEKPKPEVKPQLEKPKPEVKPQLEKPKPEVKPQLEKPKPEVKPQLEKPKPEVKPQLEKPKPEVKPQLEKPKPEVKPQLEKPKPEVKPQLEKPKPEVKPQLEKPKPEVKPQLEKPKPEVKPQLEKPKPEVKPQLEKPKPEVKPQLEKPKPEVKPQLEKPKPEVKPQLEKPKPEV

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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