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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 02-AUG-2013

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae gamPNI0373
  • locus tag: HMPREF1038_00446 [new locus tag: HMPREF1038_RS02205 ]
  • pan locus tag?: PNEUPAN001244000
  • symbol: HMPREF1038_00446
  • pan gene symbol?: yrrC
  • synonym: recD2
  • product: helicase, RecD/TraA family

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HMPREF1038_00446 [new locus tag: HMPREF1038_RS02205 ]
  • symbol: HMPREF1038_00446
  • product: helicase, RecD/TraA family
  • replicon: chromosome
  • strand: -
  • coordinates: 394378..396816
  • length: 2439
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    ATGATTGGTAACTATCTAAACTTACCAGAACAGAAACACCTCAACTCTCACCTATTCATG
    CAAAGGAATTTTATGGAAGTTTATTTTTCAGGAACCATTGAACGGATTATTTTTGAAAAT
    CCCAGCAATTTTTATCGCATCCTCCTCCTAGAAATCGACGATACGGACGCAGAGGATTTT
    GATGATTTTGAAATCATTGTCACAGGAACCATGGCTGATGTAATTGAGGGCGAAGACTAT
    ACTTTTTGGGGGCAAATTGTCCAGCACTCCAAGTATGGAGAACAACTGCAAATCAGTCGT
    TATGATCGCGCAAAACCAACTAGTAAGGGCTTGGTCAAGTACTTTTCAAGTAGCCATTTC
    AAGGGGATTGGTCTCAAGACAGCTCAGAAAATCGTGGATACCTATGGCGAAAATACCATT
    GACGAAATTTTGCAACACCCAGAAAAGTTAGAAGGCATCGCAGGATTCTCTGCCAAAAAT
    CGCGAGGCTTTCGTCTCCACTCTCCGTCTCAACTACGGAACGGAGATGGTTTTGTCCAAA
    CTAGCCAACTACGGCATTCCCAACAAACTAGCCTTTCAGATTCAAGACTTTTACAAGGAA
    GAAACCCTTGATGTGGTTGAAAATTATCCCTACCAGCTGGTTGAGGATATCAAGGGTTTG
    GGCTTTACCATTGCTGACCAACTAGCTGAGGAACTAGGCATCGAAAGTCAGGCTCCTGAA
    CGCTTCCGCGCCGGTCTAGTTCACAGTCTTTTTCAGGCCTGTATGGAAACAGGGGACACC
    TATGTTGAAGCACGGGATTTGCTGGAACAAACCCTTACTCTCCTTGAGTCTTCCCGTCCC
    GTGGAACTAGACCCCAGCCAAGTTGCCCAAGAGCTCTCCTACCTGATCGAAGAAGACAAG
    GTTCAGCAGATTGATACCAAGATCTTTGACAACAGCCTCTTTTTCGCTGAGGAAGGTATC
    CGCAGTCACTTGATTCGTATCCTTGAAAAAGGAAAACAGAAGAGCCAAGATTTAGAAACT
    ATTCAAAAGCATATCACTACTGTCGAGCAAGAGCTGGGAATTGAGTATGATAACATTCAA
    AAACAGGCTATCTGTGATGCTATCCAGAATAAGGTCTTTATCCTGACAGGTGGACCTGGT
    ACTGGTAAGACAACTGTTATCAATGGGATCATCGCTGTTTACGCCCTGTTAGAGGGACTT
    GACCTCAGGAAGAAAAGCAATCTGCCCATTCTTCTTGCTGCTCCAACTGGACGAGCCGCT
    CGCCGCATGAATGAATTGACAGGTTTGCCTAGCGCGACCATACACCGCCACTTGGGAATG
    ACAGGTGACGATGATACCAGTCATCTGGAAGATTACCTAGATGCTGACTTTATCATCGTG
    GATGAATTCTCTATGGTAGATACTTGGCTGGCCAATCAACTCTTCTCCAATATCTCTTCT
    AACAGTAAGATCCTCATCGTAGGTGACAGTGATCAGCTACCTTCTGTCAGTCCTGGACAG
    GTTCTAGCGGATCTGCTTCATATTCCTTTGATTCCTCAGACTCGCTTGGAAAAAATTTAT
    CGACAAAGCAAAGAATCAACCATCGTCACCCTAGCTAGTCAGATTCGACAGGGCATCTTG
    CCAGCTGATTTCACCCAAAAAAAAGCTGACCGTTCCTACTTTGAAATTGCTAGTGGCCAT
    ATTCCTGCCACCATTGAAAAAATCTTAGGTGTCGCCCTCAGAAATGGTATTCCTGCCCGT
    GATATCCAAGTTCTGGCTCCTATGTACCGAGGGACGGCAGGGATTGATGCTATCAATCAG
    CTCATGCAAGACCTGCTCAATCCCCCACAAAAAGATCAACTCAGTTTTGAAGCTCCTCAG
    TGCCACTATCGTAAGAGAGACAAGGTCATTCATTTGGTTAACGATGCTGAAATCAATGTC
    TTTAATGGGGATTTAGGAGCTATCACAGACCTGATTCCTGGTAAATACACCGAATCGAAA
    CAAGACGAGATTGTCATTGATTTTGATGGTAATGAAGTCTCTTACCCCCGTAACGAATGG
    TACAAGATTCGCTTGGCCTATGCCATGAGTATTCATAAGTCTCAGGGAAGTGAGTTCCCA
    GTTGTCATCCTACCGATTACTAGTGCTAGCCGACGTATGCTGGAGCGAAATCTCATCTAC
    ACAGCCATTACACGTGCCAAAAGCAAACTCATCTTACTAGGCGAATTACAAGCCTTCGAC
    TATGCTACCCAACACATCGGAACTGCCCGAAAAACCTATCTGATTGAACGCTTCAGTGAT
    CTACTGGAGAATGTTGAAGAAAAGCAACAAGCTGTCTCTGAAACAGTCACATCAAGTGCC
    TCTGAACAATCCTACATCCTAACCGAAGAAAACTGGGACCGCATCCCAGCCATGATTGGG
    ATTACAGACACAGACCTCAAAGAGATTTTTGGAAAATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2439

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HMPREF1038_00446 [new locus tag: HMPREF1038_RS02205 ]
  • symbol: HMPREF1038_00446
  • description: helicase, RecD/TraA family
  • length: 812
  • theoretical pI: 4.65685
  • theoretical MW: 91596.2
  • GRAVY: -0.264163

⊟Function[edit | edit source]

  • TIGRFAM:
    Unknown function Enzymes of unknown specificity helicase, RecD/TraA family (TIGR01448; HMM-score: 1070.2)
    and 17 more
    Genetic information processing DNA metabolism DNA replication, recombination, and repair exodeoxyribonuclease V, alpha subunit (TIGR01447; EC 3.1.11.5; HMM-score: 222.5)
    Ti-type conjugative transfer relaxase TraA (TIGR02768; HMM-score: 77.5)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair putative DNA helicase (TIGR00376; EC 3.6.4.12; HMM-score: 26.1)
    conjugative transfer relaxase protein TraI (TIGR02760; EC 3.6.4.12; HMM-score: 24.4)
    Cellular processes Cellular processes Sporulation and germination stage V sporulation protein K (TIGR02881; HMM-score: 18.2)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair helicase-exonuclease AddAB, AddA subunit (TIGR02785; EC 3.1.-.-,3.6.4.12; HMM-score: 17.7)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA helicase II (TIGR01075; EC 3.6.4.12; HMM-score: 16.1)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair ATP-dependent DNA helicase PcrA (TIGR01073; EC 3.6.4.12; HMM-score: 15.6)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA topoisomerase IV, B subunit (TIGR01058; EC 5.99.1.-; HMM-score: 14.7)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair Holliday junction DNA helicase RuvA (TIGR00084; EC 3.6.4.12; HMM-score: 14.1)
    P-type DNA transfer ATPase VirB11 (TIGR02788; HMM-score: 13.9)
    Cellular processes Cellular processes Conjugation P-type conjugative transfer ATPase TrbB (TIGR02782; HMM-score: 13.6)
    Cellular processes Cellular processes Chemotaxis and motility flagellar biosynthesis protein FlhF (TIGR03499; HMM-score: 13.3)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type VII secretion AAA-ATPase EccA (TIGR03922; HMM-score: 13.2)
    Metabolism Transport and binding proteins Amino acids, peptides and amines LAO/AO transport system ATPase (TIGR00750; EC 2.7.-.-; HMM-score: 13.1)
    Signal transduction Regulatory functions Protein interactions LAO/AO transport system ATPase (TIGR00750; EC 2.7.-.-; HMM-score: 13.1)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking signal recognition particle-docking protein FtsY (TIGR00064; HMM-score: 12.7)
  • TheSEED  :
    • RecD-like DNA helicase YrrC
    DNA Metabolism DNA repair DNA repair, bacterial RecBCD pathway  RecD-like DNA helicase YrrC
  • PFAM:
    P-loop_NTPase (CL0023) AAA_30; AAA domain (PF13604; HMM-score: 136.5)
    AAA_19; AAA domain (PF13245; HMM-score: 114.8)
    and 25 more
    HHH (CL0198) HHH_4; Helix-hairpin-helix containing domain (PF14490; HMM-score: 99.6)
    P-loop_NTPase (CL0023) UvrD_C_2; UvrD-like helicase C-terminal domain (PF13538; HMM-score: 68.1)
    SH3 (CL0010) SH3_13; ATP-dependent RecD-like DNA helicase SH3 domain (PF18335; HMM-score: 60.6)
    P-loop_NTPase (CL0023) Viral_helicase1; Viral (Superfamily 1) RNA helicase (PF01443; HMM-score: 45.3)
    AAA_11; AAA domain (PF13086; HMM-score: 34.5)
    UvrD_C; UvrD-like helicase C-terminal domain (PF13361; HMM-score: 29.1)
    UvrD-helicase; UvrD/REP helicase N-terminal domain (PF00580; HMM-score: 22.2)
    HHH (CL0198) HHH_5; Helix-hairpin-helix domain (PF14520; HMM-score: 20.1)
    P-loop_NTPase (CL0023) PhoH; PhoH-like protein (PF02562; HMM-score: 19)
    DEAD; DEAD/DEAH box helicase (PF00270; HMM-score: 18.2)
    RsgA_GTPase; RsgA GTPase (PF03193; HMM-score: 18.2)
    AAA_22; AAA domain (PF13401; HMM-score: 17.9)
    Herpes_Helicase; Helicase (PF02689; HMM-score: 15.3)
    NTPase_1; NTPase (PF03266; HMM-score: 14.8)
    AAA_12; AAA domain (PF13087; HMM-score: 14.4)
    5_3_exonuc_C (CL0464) 5_3_exonuc; 5'-3' exonuclease, C-terminal SAM fold (PF01367; HMM-score: 14.3)
    P-loop_NTPase (CL0023) T2SSE; Type II/IV secretion system protein (PF00437; HMM-score: 13.8)
    AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 13.5)
    AAA_28; AAA domain (PF13521; HMM-score: 13.1)
    MeaB; Methylmalonyl Co-A mutase-associated GTPase MeaB (PF03308; HMM-score: 13)
    Helicase_RecD; Helicase (PF05127; HMM-score: 12.8)
    AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 12.5)
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 12.5)
    DUF2075; Schlafen group 3, DNA/RNA helicase domain (PF09848; HMM-score: 10.8)
    ABC_tran; ABC transporter (PF00005; HMM-score: 10.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9827
    • Cytoplasmic Membrane Score: 0.0108
    • Cell wall & surface Score: 0.0013
    • Extracellular Score: 0.0051
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.000835
    • TAT(Tat/SPI): 0.000111
    • LIPO(Sec/SPII): 0.000208
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: AFS42519 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MIGNYLNLPEQKHLNSHLFMQRNFMEVYFSGTIERIIFENPSNFYRILLLEIDDTDAEDFDDFEIIVTGTMADVIEGEDYTFWGQIVQHSKYGEQLQISRYDRAKPTSKGLVKYFSSSHFKGIGLKTAQKIVDTYGENTIDEILQHPEKLEGIAGFSAKNREAFVSTLRLNYGTEMVLSKLANYGIPNKLAFQIQDFYKEETLDVVENYPYQLVEDIKGLGFTIADQLAEELGIESQAPERFRAGLVHSLFQACMETGDTYVEARDLLEQTLTLLESSRPVELDPSQVAQELSYLIEEDKVQQIDTKIFDNSLFFAEEGIRSHLIRILEKGKQKSQDLETIQKHITTVEQELGIEYDNIQKQAICDAIQNKVFILTGGPGTGKTTVINGIIAVYALLEGLDLRKKSNLPILLAAPTGRAARRMNELTGLPSATIHRHLGMTGDDDTSHLEDYLDADFIIVDEFSMVDTWLANQLFSNISSNSKILIVGDSDQLPSVSPGQVLADLLHIPLIPQTRLEKIYRQSKESTIVTLASQIRQGILPADFTQKKADRSYFEIASGHIPATIEKILGVALRNGIPARDIQVLAPMYRGTAGIDAINQLMQDLLNPPQKDQLSFEAPQCHYRKRDKVIHLVNDAEINVFNGDLGAITDLIPGKYTESKQDEIVIDFDGNEVSYPRNEWYKIRLAYAMSIHKSQGSEFPVVILPITSASRRMLERNLIYTAITRAKSKLILLGELQAFDYATQHIGTARKTYLIERFSDLLENVEEKQQAVSETVTSSASEQSYILTEENWDRIPAMIGITDTDLKEIFGK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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