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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 02-AUG-2013

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae gamPNI0373
  • locus tag: HMPREF1038_00613 [new locus tag: HMPREF1038_RS03030 ]
  • pan locus tag?: PNEUPAN001484000
  • symbol: HMPREF1038_00613
  • pan gene symbol?: pnp
  • synonym:
  • product: polyribonucleotide nucleotidyltransferase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HMPREF1038_00613 [new locus tag: HMPREF1038_RS03030 ]
  • symbol: HMPREF1038_00613
  • product: polyribonucleotide nucleotidyltransferase
  • replicon: chromosome
  • strand: +
  • coordinates: 553469..555733
  • length: 2265
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    TTGATCTTTGTAGGCAAGGCGTATAATTTCATCAATCAAAAGGGGATTAAAATGGCAAAA
    CAAGTGTTTCAAACGACTTTTGCGGGTCGTGAGTTAATTGTAGAGACTGGTCAGGTTGCT
    AAGCAAGCAAATGGATCTGTTGTCGTACGTTACGGTGAGTCAACTGTCTTGACTGCTGCC
    GTTATGTCTAAGAAAATGGCAACTGGGGATTTCTTCCCACTCCAAGTCAACTACGAAGAA
    AAAATGTATGCGGCTGGGAAGTTTCCTGGTGGCTTTATGAAACGTGAAGGACGTCCTTCA
    ACAGATGCGACCTTGACAGCGCGTTTGATTGACCGTCCGATTCGTCCTATGTTTGCGGAA
    GGTTTCCGTAATGAAGTCCAAGTCATCAATACAGTGCTTTCTTATGATGAAAATGCATCT
    GCACCAATGGCTGCTATGTTTGGTTCATCTTTGGCACTGTCTATTTCAGATATTCCATTT
    GACGGACCAATTGCTGGGGTACAAGTGGGATATGTAGATGGCCAAATCATCATCAACCCA
    AGTCAAGAACAAGCAGAGCAATCTCTTCTTGAATTGACAGTAGCTGGAACCAAGCACGCT
    ATCAACATGGTAGAGTCTGGTGCCAAAGAATTGTCAGAAGAAATCATGTTGGAAGCGCTT
    CTTAAAGGGCACGAAGCTGTCAAAGAATTGATTACCTTCCAAGAAGAAATCGTTGCTGCT
    GTCGGTAAAGAAAAAGCAGAAGTGGAATTGCTTCACGTGGATGCTGAATTGCAAGCTGAA
    ATCATTGCAGCCTACAACAGTGACCTCCAAAAGGCAGTTCAAGTAGAAGAGAAATTGGCC
    CGTGAAGCTGCAACTCAAGCAGTGAAAGACCAAGTGACTGCCGTTTACGAAGAAAAATAT
    GCGAACCACGAAGAATTTGACCGTATTATGCGTGATGTGGCTGAAATCTTGGAACAAATG
    GAACACGCAGAAGTGCGACGTTTAATTACAGAAGACAAGGTGCGTCCTGATGGTCGTAAG
    GTCGATGAAATCCGTCATTTGGATGCGGTTGTTGACTTCCTTCCTCGTGTACATGGTTCA
    GGTCTCTTTACTCGTGGGCAAACTCAAGCTCTTTCAGTCTTGACCTTGGCTCCGATGGGA
    GAAACTCAAATCATTGATGGTTTGGATCCAGAGTACAAGAAACGCTTTATGCACCACTAT
    AACTTCCCTCAATATTCTGTAGGGGAAACAGGTCGTTACGGTGCGCCAGGTCGTCGTGAA
    ATCGGTCACGGTGCTCTTGGTGAGCGTGCTCTTGCTCAAGTCTTGCCAAGCTTGGAAGAA
    TTCCCATACGCTATCCGTCTAGTAGCAGAAGTTTTGGAATCAAACGGTTCTTCATCTCAA
    GCTTCTATCTGTGCGGGAACTCTTGCCCTTATGGCTGGTGGTGTGCCAATCAAGGCGCCA
    GTAGCTGGTATTGCTATGGGACTTATCTCAGATGGAAATAACTACACAGTATTGACAGAT
    ATCCAAGGTTTGGAAGATCACTTTGGAGATATGGACTTCAAGGTTGCAGGTACTCGTGAT
    GGGATTACAGCCCTTCAAATGGATATCAAGATTCAAGGGATTACTGCAGAAATCTTGACG
    GAGGCTCTTGCTCAAGCCAAGAAAGCGCGTTTTGAAATCCTTGATGTCATTGAAGCAACC
    ATTCCAGAAGTTCGTCCAGAATTGGCTCCAACTGCTCCGAAAATTGATACGATCAAGATT
    GATGTGGACAAGATTAAGATTGTCATCGGTAAGGGTGGAGAAACCATCGACAAGATTATC
    GCTGAAACAGGTGTTAAGATTGATATAGACGAAGAAGGAAATGTGTCTATCTACTCTAGT
    GACCAAGATGCTATTAACCGTGCCAAAGAAATTATTGCTGGTTTGGTTCGTGAAGCCAAA
    GTGGATGAAGTTTACCGTGCTAAAGTCGTTCGTATCGAGAAATTTGGTGCCTTTGTTAAC
    CTCTTTGATAAGACAGATGCCCTTGTTCATATCTCTGAGATGGCTTGGACTCGTACCAAT
    CGTGTAGAGGATTTGGTAGAAATCGGGGATGAAGTTGATGTTAAGGTTATCAAGATTGAT
    GAAAAAGGCCGTATCGATGCCTCTATGAAGGCTCTTCTACCTCGTCCGCCAAAACCTGAG
    CATGATGAAAAAGGTGAAAAGTCTGAGCGCCCTCACCGCCCACGTCATCAAAAGGATCAC
    AAACCTAAGAAAGAATTTACAGAAACACCAAAAGATTCAGAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2265

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HMPREF1038_00613 [new locus tag: HMPREF1038_RS03030 ]
  • symbol: HMPREF1038_00613
  • description: polyribonucleotide nucleotidyltransferase
  • length: 754
  • theoretical pI: 4.90321
  • theoretical MW: 83014.2
  • GRAVY: -0.247347

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Transcription Degradation of RNA polyribonucleotide nucleotidyltransferase (TIGR03591; EC 2.7.7.8; HMM-score: 991)
    and 5 more
    guanosine pentaphosphate synthetase I/polyribonucleotide nucleotidyltransferase (TIGR02696; EC 2.7.-.-,2.7.7.8; HMM-score: 656)
    Genetic information processing Transcription Degradation of RNA exosome complex exonuclease 1 (TIGR02065; EC 3.1.13.-; HMM-score: 113.4)
    Genetic information processing Protein synthesis Ribosomal proteins: synthesis and modification ribosomal protein bS1 (TIGR00717; HMM-score: 59.1)
    Genetic information processing Transcription RNA processing ribonuclease PH (TIGR01966; EC 2.7.7.56; HMM-score: 32.9)
    arCOG04150 universal archaeal KH domain protein (TIGR03665; HMM-score: 30.9)
  • TheSEED  :
    • Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8)
  • PFAM:
    S5 (CL0329) RNase_PH; 3' exoribonuclease family, domain 1 (PF01138; HMM-score: 123.3)
    and 11 more
    no clan defined RNase_PH_C; 3' exoribonuclease family, domain 2 (PF03725; HMM-score: 84.2)
    OB (CL0021) S1; S1 RNA binding domain (PF00575; HMM-score: 65.1)
    no clan defined PNPase; Polyribonucleotide nucleotidyltransferase, RNA binding domain (PF03726; HMM-score: 47.1)
    KH (CL0007) KH_1; KH domain (PF00013; HMM-score: 40)
    KH_2; KH domain (PF07650; HMM-score: 21)
    OB (CL0021) S1_2; S1 domain (PF13509; HMM-score: 17.9)
    no clan defined DUF4404; Domain of unknown function (DUF4404) (PF14357; HMM-score: 12.9)
    SPATA25; Spermatogenesis-associated protein 25 (PF15218; HMM-score: 12.4)
    Cmr7A; CRISPR system CMR subunit Cmr7 1 (PF19021; HMM-score: 10.4)
    OB (CL0021) PCB_OB; Penicillin-binding protein OB-like domain (PF17092; HMM-score: 10.2)
    FMN-binding (CL0336) DUF2255; Uncharacterized protein conserved in bacteria (DUF2255) (PF10012; HMM-score: 8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9894
    • Cytoplasmic Membrane Score: 0.0006
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.01
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.007908
    • TAT(Tat/SPI): 0.001258
    • LIPO(Sec/SPII): 0.000779
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: AFS42684 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MIFVGKAYNFINQKGIKMAKQVFQTTFAGRELIVETGQVAKQANGSVVVRYGESTVLTAAVMSKKMATGDFFPLQVNYEEKMYAAGKFPGGFMKREGRPSTDATLTARLIDRPIRPMFAEGFRNEVQVINTVLSYDENASAPMAAMFGSSLALSISDIPFDGPIAGVQVGYVDGQIIINPSQEQAEQSLLELTVAGTKHAINMVESGAKELSEEIMLEALLKGHEAVKELITFQEEIVAAVGKEKAEVELLHVDAELQAEIIAAYNSDLQKAVQVEEKLAREAATQAVKDQVTAVYEEKYANHEEFDRIMRDVAEILEQMEHAEVRRLITEDKVRPDGRKVDEIRHLDAVVDFLPRVHGSGLFTRGQTQALSVLTLAPMGETQIIDGLDPEYKKRFMHHYNFPQYSVGETGRYGAPGRREIGHGALGERALAQVLPSLEEFPYAIRLVAEVLESNGSSSQASICAGTLALMAGGVPIKAPVAGIAMGLISDGNNYTVLTDIQGLEDHFGDMDFKVAGTRDGITALQMDIKIQGITAEILTEALAQAKKARFEILDVIEATIPEVRPELAPTAPKIDTIKIDVDKIKIVIGKGGETIDKIIAETGVKIDIDEEGNVSIYSSDQDAINRAKEIIAGLVREAKVDEVYRAKVVRIEKFGAFVNLFDKTDALVHISEMAWTRTNRVEDLVEIGDEVDVKVIKIDEKGRIDASMKALLPRPPKPEHDEKGEKSERPHRPRHQKDHKPKKEFTETPKDSE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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