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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 24-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_RS03335 [old locus tag: SPH_0686 ]
  • pan locus tag?: PNEUPAN001484000
  • symbol: pnp
  • pan gene symbol?: pnp
  • synonym:
  • product: polyribonucleotide nucleotidyltransferase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_RS03335 [old locus tag: SPH_0686 ]
  • symbol: pnp
  • product: polyribonucleotide nucleotidyltransferase
  • replicon: chromosome
  • strand: +
  • coordinates: 632497..634710
  • length: 2214
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    ATGGCAAAACAAGTGTTTCAAACGACTTTTGCGGGTCGTGAGTTAATTGTAGAGACTGGT
    CAGGTTGCTAAGCAAGCAAATGGCTCTGTTGTCGTACGTTACGGTGAGTCAACTGTCTTG
    ACTGCTGCCGTTATGTCTAAGAAAATGGCAACTGGGGATTTCTTCCCCCTCCAAGTCAAC
    TACGAAGAAAAAATGTATGCGGCTGGGAAGTTTCCTGGTGGCTTTATGAAACGTGAAGGA
    CGTCCTTCAACAGATGCGACCTTGACAGCGCGTTTGATTGACCGTCCGATTCGTCCTATG
    TTTGCGGAAGGTTTTCGTAATGAAGTCCAAGTCATCAATACAGTGCTTTCTTATGATGAA
    AATGCATCTGCACCAATGGCTGCTATGTTTGGTTCATCTTTGGCACTGTCTATTTCAGAT
    ATTCCATTTGACGGACCAATTGCTGGGGTACAAGTAGGATATGTAGATGGCCAAATCATC
    ATCAACCCAAGTCAAGAACAAGCAGAGCAATCTCTTCTTGAATTGACAGTAGCTGGTACC
    AAACACGCTATCAACATGGTTGAGTCTGGTGCCAAAGAATTGTCAGAAGAAATCATGTTG
    GAAGCCCTTCTCAAAGGGCATGAAGCAGTCAAAGAATTGATTGCCTTCCAAGAAGAAATC
    GTTGCGGCAGTCGGTAAAGAAAAAGCAGAAGTGGAATTGCTTCATGTGGATGCGGACTTG
    CAGGCTGAAATCATCGCAGCTTACAACAGCGACCTCCAAAAAGCGGTTCAAGTAGAAGAA
    AAATTAGCTCGTGAAGCTGCAACTCAAACAGTTAAAGACCAAGTTATTGCTGTTTACGAA
    GAAAAATATGCAGACCACGAAGAATTTGACCGTATCATGCGTGATGTGGCTGAAATCTTG
    GAACAAATGGAACACGCTGAAGTGCGCCGTTTGATTACAGAAGACAAGGTGCGTCCTGAC
    GGTCGTAAGGTTGATGAAATCCGTCCTTTGGATGCGGTTGTTGACTTCCTTCCTCGTGTG
    CACGGTTCAGGTCTCTTCACTCGTGGACAAACTCAAGCTCTTTCAGTCTTGACCTTGGCT
    CCGATGGGTGAGACTCAAATTATCGATGGCTTGGATCCTGAGTACAAGAAACGCTTTATG
    CACCACTATAACTTCCCTCAATATTCTGTAGGGGAAACTGGTCGTTACGGTGCGCCAGGT
    CGTCGTGAAATCGGTCACGGTGCTCTTGGTGAGCGTGCTCTTGCTCAAGTCTTGCCAAGT
    TTGGAAGAATTTCCATATGCTATCCGCTTGGTAGCTGAGGTCTTGGAATCAAATGGTTCT
    TCATCTCAAGCTTCTATCTGTGCGGGAACGCTTGCCCTTATGGCTGGTGGTGTGCCAATC
    AAGGCGCCAGTAGCAGGGATTGCCATGGGTCTCATCTCAGATGGAAATAACTACACAGTC
    TTGACAGATATCCAAGGTTTGGAAGATCACTTTGGAGATATGGACTTTAAGGTTGCTGGT
    ACTCGTGACGGGATTACAGCCCTTCAAATGGATATCAAGATTCAAGGAATCACTGCAGAA
    ATCTTGACGGAGGCTCTTGCTCAAGCCAAGAAAGCGCGTTTTGAAATCCTTGATGTGATT
    GAAGCAACGATTCCAGAAGTTCGTCCAGAATTGGCTCCAACTGCTCCGAAAATTGATACC
    ATCAAGATTGATGTGGACAAGATTAAGATTGTCATCGGTAAGGGTGGAGAAACCATCGAC
    AAGATTATCGCTGAAACAGGCGTTAAGATTGATATCGACGAAGAAGGGAATGTGTCTATC
    TACTCTAGCGACCAAGATGCCATTAACCGTGCTAAAGAAATTATTGCTGGTTTGGTCCGT
    GAAGCCAAAGTGGATGAAGTTTACCGTGCTAAAGTCGTTCGTATCGAGAAATTTGGTGCT
    TTTGTCAACCTCTTTGATAAGACAGATGCCCTTGTTCATATCTCTGAAATGGCTTGGACG
    CGTACCAATAATGTCGAAGACTTGGTAGCAATCGGGGATGAAGTTGATGTTAAGGTTATC
    AAGATTGATGAAAAAGGACGTGTGGATGCTTCTATGAAAGCCCTTCTTCCTCGTCCTCCA
    AAACCTGAACGTGATGAAAAAGGTGAAAAATCAGAGCGTCCTTACCGCCCACGTCATCAC
    AAGGATCACAAACCTAAGAAAGAAATTACAGAAACACCAAAAGATTCAGAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2214

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_RS03335 [old locus tag: SPH_0686 ]
  • symbol: Pnp
  • description: polyribonucleotide nucleotidyltransferase
  • length: 737
  • theoretical pI: 4.75305
  • theoretical MW: 80925.7
  • GRAVY: -0.235821

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.7.8?  ExPASy
    Polyribonucleotide nucleotidyltransferase RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate
  • TIGRFAM:
    Genetic information processing Transcription Degradation of RNA polyribonucleotide nucleotidyltransferase (TIGR03591; EC 2.7.7.8; HMM-score: 991.7)
    and 5 more
    guanosine pentaphosphate synthetase I/polyribonucleotide nucleotidyltransferase (TIGR02696; EC 2.7.-.-,2.7.7.8; HMM-score: 656)
    Genetic information processing Transcription Degradation of RNA exosome complex exonuclease 1 (TIGR02065; EC 3.1.13.-; HMM-score: 114.5)
    Genetic information processing Protein synthesis Ribosomal proteins: synthesis and modification ribosomal protein bS1 (TIGR00717; HMM-score: 59)
    Genetic information processing Transcription RNA processing ribonuclease PH (TIGR01966; EC 2.7.7.56; HMM-score: 34.8)
    arCOG04150 universal archaeal KH domain protein (TIGR03665; HMM-score: 30.9)
  • TheSEED: see SPH_0686
  • PFAM:
    S5 (CL0329) RNase_PH; 3' exoribonuclease family, domain 1 (PF01138; HMM-score: 125.1)
    and 8 more
    no clan defined RNase_PH_C; 3' exoribonuclease family, domain 2 (PF03725; HMM-score: 84.3)
    OB (CL0021) S1; S1 RNA binding domain (PF00575; HMM-score: 65.7)
    no clan defined PNPase; Polyribonucleotide nucleotidyltransferase, RNA binding domain (PF03726; HMM-score: 45.6)
    KH (CL0007) KH_1; KH domain (PF00013; HMM-score: 39.8)
    KH_2; KH domain (PF07650; HMM-score: 22.6)
    OB (CL0021) S1_2; S1 domain (PF13509; HMM-score: 17.1)
    no clan defined SPATA25; Spermatogenesis-associated protein 25 (PF15218; HMM-score: 12.5)
    OB (CL0021) PCB_OB; Penicillin-binding protein OB-like domain (PF17092; HMM-score: 9.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9901
    • Cytoplasmic Membrane Score: 0.0006
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0092
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.008568
    • TAT(Tat/SPI): 0.00198
    • LIPO(Sec/SPII): 0.001251
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MAKQVFQTTFAGRELIVETGQVAKQANGSVVVRYGESTVLTAAVMSKKMATGDFFPLQVNYEEKMYAAGKFPGGFMKREGRPSTDATLTARLIDRPIRPMFAEGFRNEVQVINTVLSYDENASAPMAAMFGSSLALSISDIPFDGPIAGVQVGYVDGQIIINPSQEQAEQSLLELTVAGTKHAINMVESGAKELSEEIMLEALLKGHEAVKELIAFQEEIVAAVGKEKAEVELLHVDADLQAEIIAAYNSDLQKAVQVEEKLAREAATQTVKDQVIAVYEEKYADHEEFDRIMRDVAEILEQMEHAEVRRLITEDKVRPDGRKVDEIRPLDAVVDFLPRVHGSGLFTRGQTQALSVLTLAPMGETQIIDGLDPEYKKRFMHHYNFPQYSVGETGRYGAPGRREIGHGALGERALAQVLPSLEEFPYAIRLVAEVLESNGSSSQASICAGTLALMAGGVPIKAPVAGIAMGLISDGNNYTVLTDIQGLEDHFGDMDFKVAGTRDGITALQMDIKIQGITAEILTEALAQAKKARFEILDVIEATIPEVRPELAPTAPKIDTIKIDVDKIKIVIGKGGETIDKIIAETGVKIDIDEEGNVSIYSSDQDAINRAKEIIAGLVREAKVDEVYRAKVVRIEKFGAFVNLFDKTDALVHISEMAWTRTNNVEDLVAIGDEVDVKVIKIDEKGRVDASMKALLPRPPKPERDEKGEKSERPYRPRHHKDHKPKKEITETPKDSE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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