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serotype 4
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AP200
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serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
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serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
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R6
serotype 2
SP49
serotype 19A
SPN032672
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SPN034156
serotype 3
SPN034183
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SPN994038
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SPN994039
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SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 02-AUG-2013

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae gamPNI0373
  • locus tag: HMPREF1038_01046 [new locus tag: HMPREF1038_RS05155 ]
  • pan locus tag?: PNEUPAN002291000
  • symbol: HMPREF1038_01046
  • pan gene symbol?: rexB
  • synonym:
  • product: ATP-dependent nuclease subunit B

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HMPREF1038_01046 [new locus tag: HMPREF1038_RS05155 ]
  • symbol: HMPREF1038_01046
  • product: ATP-dependent nuclease subunit B
  • replicon: chromosome
  • strand: -
  • coordinates: 967497..970796
  • length: 3300
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    2701
    2761
    2821
    2881
    2941
    3001
    3061
    3121
    3181
    3241
    ATGAAAAATTCCAACGAGGCTGAGATGAAATTACTTTATACTGATATTCGGACTTCTTTG
    ACAGAAATTCTAACAAGAGAGGCAGAAGAGCTAGTTGCAGCTGGCAAGCGGGTCTTCTAC
    ATTGCCCCCAACTCTCTTTCTTTTGAAAAGGAACGCGCCGTGCTGGAATGCTTGTCCCAG
    CAGGCTTCTTTTTCGATTACCGTCACGCGCTTTGCTCAAATGGCTCGTTATCTGGTCTTG
    AATGATTTACCAGCTAAAACTACTCTTGATGATATCGGTCTTGGGTTGGCCTTTTACAAA
    TGCCTTGCCGAACTCGATCCCAAGGACTTGCGTGTTTATGGCGCTATTAAGCAGGATCCT
    CAATTGATCCAGCAGTTAATTGAGCTTTACCATGAGATGACCAAATCCCAGATGAGTTTT
    TTGGACTTGGAGAATTTAACAGATGAGGATAAGAGGGCGGATTTACTCTTGATTTTTGAG
    AAAGTAACAGCCTATCTTAATCAAGGTCAGTTAGCCCAGGGAAGTCAGTTGTCCCATTTG
    ATTGAGGCTATTGAGAATGACAAGGTAAGTAGTGATTTTAATCAAATCACCTTGGTCATT
    GACGGCTTTACTCGTTTTTCTGCTGAGGAAGAGCGGGTTGTGGACTTACTTCACGGCAAA
    GGTGTTGAGATTGTTATCGGGGCTTATGCTAGTAAGAAAGCCTATACCAGTCCTTTTAGC
    GAGGGCAATCTCTACCAAGCCAGCGTAAAATTTCTCCATCATCTGGCTTCTAAATACCAA
    ACGCCTGCTCAGGACTGTTCTCAAACTCATGAGAAGATGGATAGTTTTGACAAGGCCTCT
    CGTTTGTTGGAGTCTTCTTATGACTTTTCAGAACTCGCTTTGGATGTCGATGAGAAAGAC
    CGTGAAAATTTACAAATCTGGTCTTGTTTGACGCAAAAGGAGGAGTTGGAGCTAGTAGCC
    CGTAGTATTCGTCAGAAATTACATGAGAACTCAGACCTGAGCTACAAGCATTTTCGTATT
    CTCTTGGGGGATGTAGCTTCTTACCAGTTATCTCTCAAAACCATTTTTGACCAGTATCAG
    ATTCCTTTTTATCTTGGTAGAAGCGAAGCCATGGCTCATCATCCCTTGACTCAGTTTGTC
    GAGTCTATTTTAGCTTTAAAACGTTACCGTTTTCGTCAGGAGGATTTGATTAATCTTCTT
    AGAACTGATTTGTATACTGACCTCAGTCAGTCTGATATTGATGCTTTTGAGCAATATATC
    CGCTATCTTGGTATCAATGGCTTGCCAGCCTTTCAGCAAATCTTCACCAAATCCCACCAT
    GGAAAATTTAATCTTGAGCGTTTGAATGTCCTCCGCCTGAGAATTTTAGCACCTCTTGAA
    ACCCTCTTTGCCAGCCGAAAACAAAAGGCTGAAAACCTCCTACAAAAATGGAGTGTCTTT
    CTAAAAGAAGGAGCTGTGACCAAGCAGTTACAAGATTTGACAACCACTTTGGAAGCTGTA
    GAACAGGAAAGACAAGCCGAAGTTTGGAAGGCTTTCTGCCATGTTTTAGAACAATTTGCG
    ACTGTTTTTGCTGGTTCACAGGTTAGTCTGGAAGACTTCCTAGCCTTGCTCCATTCTGGA
    ATGAGTTTGTCCCAATACCGTACCATTCCAGCAACAGTGGACACTGTTCTGGTGCAGAGT
    TACGATTTGATTGCACCATTGACTGCTGACTTTGTCTATGCTATTGGACTAACTCAGGAC
    AATTTACCAAAAATTTCTCAAAACACCAGTCTTCTGACAGATGAAGAAAGGCAAAACCTA
    AACCAAGCGACCGAAGAAGGCGTTCAATTACTGATTGCCAGCAGTGAAAATCTCAAGAAA
    AATCGCTACACTATGCTTTCCTTGGTCAATTCTGCTCGTAAGCAGTTGTTCTTGTCGGCT
    CCAAGCCTTTTTAACGAAAGTGAAAGTAAGGAATCTGCCTATCTTCAAGAGTTGATCCAT
    TTTGGATTTAGGCGGAGAGAGAAGAGGATGAATCACAAAGGACTGTCTAAGGAGGATATG
    GGGTCCTATCACAGTCTTTTGTCTAGTCTGGTTGCCTATCACCAGCAGGGTGAGATGAGC
    GATACTGAGCAAGATTTGACTTTTGTCAAGGTTCTGTCGCGTGTCATAGGTAAAAAACTA
    GATCTGCAAGGTCTGGAAAATCCAGCTATCCCAACCAGTCCAAGCAGCAAGACCTTAGCC
    AAGGACACCTTGCAAGCTCTCTATCCTGCCAAACAGGAGTTTTACCTGTCTACGTCGGGT
    TTGACAGAGTTTTATCGCAATGAATACAGTTATTTCCTACGCTACGTTTTAGGCTTGCAG
    GAGGAATTACGTTTGCGTCCTGATGCCCGTAGTCACGGGAATTTCTTGCATCGTATCTTT
    GAACGCGCCTTACAGTTGCCTAATGAAGATTCCTTTGACCAACGTCTAGAACAAGCTATT
    CAAGAAACCAGTCAAGAACGCGAATTTGAAGCTATTTATCAAGAAAGTTTGGAAGCCCAG
    TTTACCAAGGAAGTTTTGCTTGATGTTGCACGGACGACTGGACATATTCTCCGACACAAT
    CCAGCCATCGAAACCATCAAAGAAGAAGCAAATTTTGGTGGAAAAGACCAAGCCTTTATT
    CAATTAGACAATGGACGCAGTGTCTTTGTACGAGGCAAGGTGGACCGGATTGACCGTTTG
    AAAGCTAATGGAGCGATAGGAGTAGTAGACTACAAATCCAGTCTGACTCAGTTCCAGTTT
    CCTCATTTCTTTAATGGGCTCAATTCTCAGTTACCAACCTATCTTGCTGCCCTAAAAAGA
    GAAGGGAAGCAGAACTTTTTCGGCGCCATGTACTTGGAAATGGCTGAACCTGTCCAATCT
    CTGATGGCGGTAAAAAGTCTGGCAGGAGCAGTGGTAGAAGCCAGCAAATCTATGAAATAC
    CAAGGGCTCTTCTTGGAAAAAGAAAGCAGTTATTTAGGCGAATTTTATAACAAAAACAAG
    GCTAATCAACTGACAGATGAGGAATTTCAGCTCCTACTGGACTACAATGCCTATCTTTAC
    AAGAAAGCTGCTGAGAAGATTTTAGCAGGCCGGTTCGCCATCAATCCTTATACTGAAAAT
    GGCAGAAGCATTGCCCCATACGTCCAGCAACATCAGGCTATTACAGGCTTTGAAGCCAAT
    TACCATCTGGGCCAAGCCCGTTTCCTAGAAAAATTGGACCTAGCTGATGGCAAGCGTCTG
    GTCGGAGAAAAACTCAAGCAAGCTTGGTTTGAAAAAATAAGAGAGGAGTTAAATCGATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2520
    2580
    2640
    2700
    2760
    2820
    2880
    2940
    3000
    3060
    3120
    3180
    3240
    3300

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HMPREF1038_01046 [new locus tag: HMPREF1038_RS05155 ]
  • symbol: HMPREF1038_01046
  • description: ATP-dependent nuclease subunit B
  • length: 1099
  • theoretical pI: 5.8259
  • theoretical MW: 125690
  • GRAVY: -0.365423

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing DNA metabolism DNA replication, recombination, and repair ATP-dependent nuclease subunit B (TIGR02774; HMM-score: 1810.8)
    and 1 more
    Genetic information processing DNA metabolism DNA replication, recombination, and repair helicase-exonuclease AddAB, AddB subunit (TIGR02773; EC 3.1.-.-,3.6.4.12; HMM-score: 301.3)
  • TheSEED  :
    • ATP-dependent nuclease, subunit B
    DNA Metabolism DNA repair ATP-dependent Nuclease  ATP-dependent nuclease, subunit B
  • PFAM:
    PDDEXK (CL0236) PDDEXK_1; PD-(D/E)XK nuclease superfamily (PF12705; HMM-score: 101.4)
    and 3 more
    no clan defined Arg_decarb_HB; Arginine decarboxylase helical bundle domain (PF17810; HMM-score: 21.6)
    Med15_fungi; Mediator complex subunit 15 (PF05397; HMM-score: 12.2)
    DUF3106; Protein of unknown function (DUF3106) (PF11304; HMM-score: 10.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 1.78
    • Cytoplasmic Membrane Score: 8.16
    • Cellwall Score: 0.06
    • Extracellular Score: 0.01
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9423
    • Cytoplasmic Membrane Score: 0.0302
    • Cell wall & surface Score: 0.0184
    • Extracellular Score: 0.0091
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.006343
    • TAT(Tat/SPI): 0.000736
    • LIPO(Sec/SPII): 0.000712
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: AFS43098 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKNSNEAEMKLLYTDIRTSLTEILTREAEELVAAGKRVFYIAPNSLSFEKERAVLECLSQQASFSITVTRFAQMARYLVLNDLPAKTTLDDIGLGLAFYKCLAELDPKDLRVYGAIKQDPQLIQQLIELYHEMTKSQMSFLDLENLTDEDKRADLLLIFEKVTAYLNQGQLAQGSQLSHLIEAIENDKVSSDFNQITLVIDGFTRFSAEEERVVDLLHGKGVEIVIGAYASKKAYTSPFSEGNLYQASVKFLHHLASKYQTPAQDCSQTHEKMDSFDKASRLLESSYDFSELALDVDEKDRENLQIWSCLTQKEELELVARSIRQKLHENSDLSYKHFRILLGDVASYQLSLKTIFDQYQIPFYLGRSEAMAHHPLTQFVESILALKRYRFRQEDLINLLRTDLYTDLSQSDIDAFEQYIRYLGINGLPAFQQIFTKSHHGKFNLERLNVLRLRILAPLETLFASRKQKAENLLQKWSVFLKEGAVTKQLQDLTTTLEAVEQERQAEVWKAFCHVLEQFATVFAGSQVSLEDFLALLHSGMSLSQYRTIPATVDTVLVQSYDLIAPLTADFVYAIGLTQDNLPKISQNTSLLTDEERQNLNQATEEGVQLLIASSENLKKNRYTMLSLVNSARKQLFLSAPSLFNESESKESAYLQELIHFGFRRREKRMNHKGLSKEDMGSYHSLLSSLVAYHQQGEMSDTEQDLTFVKVLSRVIGKKLDLQGLENPAIPTSPSSKTLAKDTLQALYPAKQEFYLSTSGLTEFYRNEYSYFLRYVLGLQEELRLRPDARSHGNFLHRIFERALQLPNEDSFDQRLEQAIQETSQEREFEAIYQESLEAQFTKEVLLDVARTTGHILRHNPAIETIKEEANFGGKDQAFIQLDNGRSVFVRGKVDRIDRLKANGAIGVVDYKSSLTQFQFPHFFNGLNSQLPTYLAALKREGKQNFFGAMYLEMAEPVQSLMAVKSLAGAVVEASKSMKYQGLFLEKESSYLGEFYNKNKANQLTDEEFQLLLDYNAYLYKKAAEKILAGRFAINPYTENGRSIAPYVQQHQAITGFEANYHLGQARFLEKLDLADGKRLVGEKLKQAWFEKIREELNR

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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