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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 15-OCT-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae gamPNI0373
  • locus tag: HMPREF1038_RS02060 [old locus tag: HMPREF1038_00417 ]
  • pan locus tag?: PNEUPAN001225000
  • symbol: HMPREF1038_RS02060
  • pan gene symbol?: aliA
  • synonym:
  • product: peptide ABC transporter substrate-binding protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HMPREF1038_RS02060 [old locus tag: HMPREF1038_00417 ]
  • symbol: HMPREF1038_RS02060
  • product: peptide ABC transporter substrate-binding protein
  • replicon: chromosome
  • strand: +
  • coordinates: 362951..364933
  • length: 1983
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_018630 (362951..364933) NCBI
  • BioCyc: HMPREF1038_RS02060 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0334 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    ATGAAAAGTTCAAAACTATTTGCCCTTGCGGGCGTGACATTATTGGCGGCGACTACTTTA
    GCTGCATGCTCTGGATCAGGTTCAAGTACTAAAGGTGAGAAGACATTCTCATACATTTAT
    GAGACAGACCCTGATAACCTCAACTATTTGACAACTGCTAAGGCTGCGACAGCAAATATT
    ACCAGTAACGTGGTTGATGGTTTGCTAGAAAATGATCGCTACGGGAACTTTGTGCCGTCT
    ATGGCTGAGGATTGGTCTGTATCCAAGGATGGATTGACTTACACTTATACTATCCGTAAG
    GATGCAAAATGGTATACTTCTGAAGGTGAAGAATACGCGGCAGTCAAAGCTCAAGACTTT
    GTAACAGGACTAAAATATGCTGCTGATAAAAAATCAGATGCTCTTTACCTTGTTCAAGAA
    TCAATCAAAGGGTTGGATGCCTATGTAAAAGGGGAAATCAAAGATTTCTCACAAGTAGGA
    ATTAAGGCTCTGGATGAACAGACAGTTCAGTACACTTTGAACAAACCAGAAAGCTTCTGG
    AATTCTAAGACAACCATGGGTGTGCTTGCGCCAGTTAATGAAGAGTTTTTGAATTCAAAA
    GGAGATGATTTTGCCAAAGCTACGGATCCAAGTAGTCTCTTGTATAACGGTCCTTATTTG
    TTGAAATCCATTGTGACCAAATCCTCTGTTGAATTTGCGAAAAATCCGAACTACTGGGAT
    AAGGACAATGTGCATGTTGACAAAGTTAAATTGTCATTCTGGGATGGTCAAGATACCAGC
    AAACCTGCAGAAAACTTTAAAGATGGTAGCCTTACAGCAGCTCGTCTCTATCCAACAAGT
    GCAAGTTTCGCAGAGCTTGAGAAGAGTATGAAGGACAATATTGTCTATACTCAACAAGAC
    TCTATTACGTATCTAGTTGGTACAAATATTGACCGTCAGTCCTATAAATACACATCTAAG
    ACCAGCGACGAACAAAAGGCATCGACTAAAAAGGCTCTCTTAAACAAGGATTTCCGTCAG
    GCTATTGCCTTTGGATTTGACCGTACAGCCTATGCCTCTCAGTTGAATGGACAAACTGGA
    GCAAGTAAAATCTTGCGTAATCTCTTTGTGCCACCAACATTTGTTCAAGCAGATGGTAAA
    AACTTTGGCGATATGGTCAAAGAGAAATTGGTCACTTATGGGGATGAATGGAAGGATGTT
    AATCTTGCAGATTCTCAGGATGGTCTTTACAATCCAGAAAAAGCCAAGGCTGAATTTGCT
    AAAGCTAAATCAGCCTTACAAGCAGAAGGAGTCCAATTCCCAATTCATTTGGATATGCCA
    GTTGACCAGACAGCAACTACAAAAGTTCAGCGCGTCCAATCTATGAAACAATCCTTGGAA
    GCAACTTTAGGAGCTGATAATGTCATTATTGATATCCAACAACTACAAAAAGACGAAGTA
    AACAATATTACATATTTTGCTGAAAATGCTGCTGGCGAAGATTGGGATTTATCAGATAAT
    GTCGGTTGGGGTCCAGACTTTGCCGATCCATCAACCTACCTTGATATCATCAAACCATCT
    GTAGGAGAAAGTACTAAAACATATTTAGGGTTTGACTCAGGGGAAGATAATGTAGCTGCT
    AAAAAAGTAGGTCTATATGACTACGAAAAATTGGTTACTGAGGCTGGTGATGAGGCTACA
    GATGTTGCTAAACGCTATGATAAATACGCTGCAGCCCAAGCTTGGTTGACAGATAGTGCT
    TTGATTATTCCAACTACATCTCGTACAGGGCGTCCAATCTTGTCTAAGATGGTACCATTT
    ACAATACCATTTGCATTGTCAGGAAATAAAGGTACAAGTGAACCAGTCTTGTATAAATAC
    TTGGAACTTCAAGACAAGGCAGTCACTGTAGATGAATACCAAAAAGCTCAGGAAAAATGG
    ATGAAAGAAAAAGAAGAGTCTAATAAAAAGGCTCAAGAAGATCTCGCAAAACATGTGAAA
    TAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    1983

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HMPREF1038_RS02060 [old locus tag: HMPREF1038_00417 ]
  • symbol: HMPREF1038_RS02060
  • description: peptide ABC transporter substrate-binding protein
  • length: 660
  • theoretical pI: 4.75494
  • theoretical MW: 73049.1
  • GRAVY: -0.533333

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Transport and binding proteins Cations and iron carrying compounds nickel ABC transporter, nickel/metallophore periplasmic binding protein (TIGR02294; HMM-score: 39.8)
  • TheSEED: see HMPREF1038_00417
  • PFAM:
    PBP (CL0177) SBP_bac_5; Bacterial extracellular solute-binding proteins, family 5 Middle (PF00496; HMM-score: 159.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cellwall
    • Cytoplasmic Score: 0.01
    • Cytoplasmic Membrane Score: 0.53
    • Cellwall Score: 8.75
    • Extracellular Score: 0.7
    • Internal Helix: 1
  • SignalP: Signal peptide LIPO(Sec/SPII) length 22 aa
    • SP(Sec/SPI): 0.001538
    • TAT(Tat/SPI): 0.000218
    • LIPO(Sec/SPII): 0.997985
    • Cleavage Site: CS pos: 22-23. LAA-CS. Pr: 0.9985
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000842582 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKSSKLFALAGVTLLAATTLAACSGSGSSTKGEKTFSYIYETDPDNLNYLTTAKAATANITSNVVDGLLENDRYGNFVPSMAEDWSVSKDGLTYTYTIRKDAKWYTSEGEEYAAVKAQDFVTGLKYAADKKSDALYLVQESIKGLDAYVKGEIKDFSQVGIKALDEQTVQYTLNKPESFWNSKTTMGVLAPVNEEFLNSKGDDFAKATDPSSLLYNGPYLLKSIVTKSSVEFAKNPNYWDKDNVHVDKVKLSFWDGQDTSKPAENFKDGSLTAARLYPTSASFAELEKSMKDNIVYTQQDSITYLVGTNIDRQSYKYTSKTSDEQKASTKKALLNKDFRQAIAFGFDRTAYASQLNGQTGASKILRNLFVPPTFVQADGKNFGDMVKEKLVTYGDEWKDVNLADSQDGLYNPEKAKAEFAKAKSALQAEGVQFPIHLDMPVDQTATTKVQRVQSMKQSLEATLGADNVIIDIQQLQKDEVNNITYFAENAAGEDWDLSDNVGWGPDFADPSTYLDIIKPSVGESTKTYLGFDSGEDNVAAKKVGLYDYEKLVTEAGDEATDVAKRYDKYAAAQAWLTDSALIIPTTSRTGRPILSKMVPFTIPFALSGNKGTSEPVLYKYLELQDKAVTVDEYQKAQEKWMKEKEESNKKAQEDLAKHVK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

J P Claverys, B Grossiord, G Alloing
Is the Ami-AliA/B oligopeptide permease of Streptococcus pneumoniae involved in sensing environmental conditions?
Res Microbiol: 2000, 151(6);457-63
[PubMed:10961459] [WorldCat.org] [DOI] (P p)A R Kerr, P V Adrian, S Estevão, R de Groot, G Alloing, J-P Claverys, T J Mitchell, P W M Hermans
The Ami-AliA/AliB permease of Streptococcus pneumoniae is involved in nasopharyngeal colonization but not in invasive disease.
Infect Immun: 2004, 72(7);3902-6
[PubMed:15213133] [WorldCat.org] [DOI] (P p)Fauzy Nasher, Manfred Heller, Lucy J Hathaway
Streptococcus pneumoniae Proteins AmiA, AliA, and AliB Bind Peptides Found in Ribosomal Proteins of Other Bacterial Species.
Front Microbiol: 2017, 8;2688
[PubMed:29379482] [WorldCat.org] [DOI] (P e)

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