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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 11-FEB-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae INV104
  • locus tag: INV104_RS14050 [old locus tag: INV104_04300 ]
  • pan locus tag?: PNEUPAN001375000
  • symbol: hsdR
  • pan gene symbol?: hsdR
  • synonym:
  • product: EcoAI/FtnUII family type I restriction enzme subunit R

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: INV104_RS14050 [old locus tag: INV104_04300 ]
  • symbol: hsdR
  • product: EcoAI/FtnUII family type I restriction enzme subunit R
  • replicon: chromosome
  • strand: -
  • coordinates: 485540..486826
  • length: 1287
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_017591 (485540..486826) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0455 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    ATGGTTGAGTTTATAAAGTCTAAGAAAGAAATGAGTGAGGAGGATATTAAAGCAAATTTC
    ATCACTCCTGCTATTGTATCCAAAGGATGGAAAAATGGTGAGCATATCGCTTACGAAGAA
    TACTTCACTGATGGTCGAATTGAGGTTAGAGGAGATAAGGCTCGTCGTAAAGAAGGAAAA
    AAATCAGACTATTCACTGTATTACCAATTTGGAACTCGAATTGCAATTGTTGAGGCAAAG
    GATAATAAACACAGCGTTCGAGCAGGATTACAACAAGCTATTGAATATGGAGAGATTTTA
    GATGTTCCATTTGTTTATTCTTCGAATGGTGATGGCTTTATTGAACACGACCGTATCACG
    AGAGAAGAACGTGAGCTGGAGTTAGACGAATTCCCTACTCGTGAAGAATTATTTTCTCGT
    ATGACGAAGGAAAAAGGATTGACGTACGAAATTACAGAAGCTATCTCAACTCCATACTAT
    ACAGACGCCTTCTCAATGAAAACGCCACGCTATTATCAGCAAATAGCTATCAACCGTACT
    ATTGAAACAGTTGCCAGAGGACAAAAACGAGTAATGTTTGTGATGGCAACAGGAACAGGG
    AAAACGTTCATGGCTTTTCAAATTATTCATCGCCTTCGAAAAGCTGGTTTGGCTAAACGA
    GTTTTATTCTTAGCAGATAGAAACATCTTAGTAGACCAAACGATGGCTGAAGACTTTAAG
    CCATTCGAAAAGGTAATGACGAAAATTACACCAAAACTTTTGACTGCTCCTGAAAAATTA
    AATTCTTTCGAAATTTATCTAGGGCTTTATCAGCAACTAACTGGTGAAGATGGAACTGAA
    ACACATTATCAAAAATTTGACAAAGACTTCTTTGATTTAATCGTAATTGATGAAGCGCAC
    CGTGGTTCAGCTAAGGAAAACAGTAACTGGCGTAAGGTAATTGATTATTTCAGTTCTGCG
    ACACAGATTGGGATGACCGCTACTCCTAAAGAAACCAAGAATGCTTCCAATACGGAATAC
    TTTGGTAAGCCAATCTATACTTATAGTTTAAAACAGGGAATCGAGGATGGTTTTTTGGCT
    CCATATCGTGTTATGAGGGTTAATTTAGATGTGGATGTGGATGGTTATCGTCCAGAAACT
    GGAAAAGTTGATGCTAACGGACAATTAATAGAAGATAGGTACTACGGCAGGAAAGATTTT
    GATAAAACCATTGTCATTGATGATAGAACGCAAAGAGTTGCCAAGTTTGTTTCTGATTAT
    TATGAAGCAAAACAATGCACGATTTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1287

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: INV104_RS14050 [old locus tag: INV104_04300 ]
  • symbol: HsdR
  • description: EcoAI/FtnUII family type I restriction enzme subunit R
  • length: 428
  • theoretical pI: 6.55018
  • theoretical MW: 49569.8
  • GRAVY: -0.613551

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing DNA metabolism Restriction/modification type I site-specific deoxyribonuclease, HsdR family (TIGR00348; EC 3.1.21.3; HMM-score: 56.9)
    DNA phosphorothioation system restriction enzyme (TIGR04095; HMM-score: 52.6)
    and 5 more
    Genetic information processing DNA metabolism DNA replication, recombination, and repair excinuclease ABC subunit B (TIGR00631; EC 3.1.25.-; HMM-score: 18.5)
    arsenical pump-driving ATPase (TIGR04291; EC 3.6.1.-; HMM-score: 14.6)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair ATP-dependent DNA helicase RecG (TIGR00643; EC 3.6.4.12; HMM-score: 14.4)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair putative DNA helicase (TIGR00376; EC 3.6.4.12; HMM-score: 14)
    Cellular processes Cellular processes Conjugation P-type conjugative transfer ATPase TrbB (TIGR02782; HMM-score: 11.4)
  • TheSEED: see INV104_04300
  • PFAM:
    P-loop_NTPase (CL0023) ResIII; Type III restriction enzyme, res subunit (PF04851; HMM-score: 146.6)
    and 11 more
    SWI2_SNF2; SWI2/SNF2 ATPase (PF18766; HMM-score: 74.4)
    DEAD; DEAD/DEAH box helicase (PF00270; HMM-score: 32.9)
    PDDEXK (CL0236) HSDR_N_2; Type I restriction enzyme R protein N terminus (HSDR_N) (PF13588; HMM-score: 20.7)
    P-loop_NTPase (CL0023) DUF2075; Schlafen group 3, DNA/RNA helicase domain (PF09848; HMM-score: 20)
    PDDEXK (CL0236) HSDR_N; Type I restriction enzyme R protein N terminus (HSDR_N) (PF04313; HMM-score: 19.1)
    P-loop_NTPase (CL0023) AAA_22; AAA domain (PF13401; HMM-score: 18.2)
    AAA_11; AAA domain (PF13086; HMM-score: 18.1)
    AAA_30; AAA domain (PF13604; HMM-score: 16.1)
    AAA_7; P-loop containing dynein motor region (PF12775; HMM-score: 16)
    PIF1; PIF1-like helicase (PF05970; HMM-score: 15.7)
    SNF2-rel_dom; SNF2-related domain (PF00176; HMM-score: 14.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.7685
    • Cytoplasmic Membrane Score: 0.0722
    • Cell wall & surface Score: 0.0056
    • Extracellular Score: 0.1537
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.009053
    • TAT(Tat/SPI): 0.000814
    • LIPO(Sec/SPII): 0.002316
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_014632356 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MVEFIKSKKEMSEEDIKANFITPAIVSKGWKNGEHIAYEEYFTDGRIEVRGDKARRKEGKKSDYSLYYQFGTRIAIVEAKDNKHSVRAGLQQAIEYGEILDVPFVYSSNGDGFIEHDRITREERELELDEFPTREELFSRMTKEKGLTYEITEAISTPYYTDAFSMKTPRYYQQIAINRTIETVARGQKRVMFVMATGTGKTFMAFQIIHRLRKAGLAKRVLFLADRNILVDQTMAEDFKPFEKVMTKITPKLLTAPEKLNSFEIYLGLYQQLTGEDGTETHYQKFDKDFFDLIVIDEAHRGSAKENSNWRKVIDYFSSATQIGMTATPKETKNASNTEYFGKPIYTYSLKQGIEDGFLAPYRVMRVNLDVDVDGYRPETGKVDANGQLIEDRYYGRKDFDKTIVIDDRTQRVAKFVSDYYEAKQCTI

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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