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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 08-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae BVJ1JL
  • locus tag: JN057_RS01115 [old locus tag: JN057_00232 ]
  • pan locus tag?: PNEUPAN000901000
  • symbol: ribD
  • pan gene symbol?: ribD
  • synonym:
  • product: bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: JN057_RS01115 [old locus tag: JN057_00232 ]
  • symbol: ribD
  • product: bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD
  • replicon: chromosome
  • strand: -
  • coordinates: 198822..199922
  • length: 1101
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_CP071871 (198822..199922) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0169 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    ATGAGCGATTCAAAATATATGAAATTAGCAATAAAACTGGCACAAAAAGGGGCTGGTTAC
    GTCAATCCCAATCCTATGGTTGGCGCAATTATTGTAAAAGATAATCACATTATCGGACAA
    GGTTATCATGAGTTTTTTGGTGGCCCACATGCTGAGAGAAATGCTCTTAAAAACTGTAGA
    AAATCCCCTGTCGGAGCGACGCTTTATGTAACACTTGAACCCTGTTGTCACTTCGGGAAA
    ACACCTCCCTGTATAGATGCTATAATCGATAGTGGTATTACAAGAGTAGTCATTGGAAGC
    CTAGACTGTAATCCTATTGTATCTGGAAAAGGAGTAAAGATACTTGAGGAAAATAATCTT
    CAAGTTACTGTTGGAATTTTAGAAAATGAGTGTCTTAACTTAATAAAAAGTTTTAGAAAG
    TATATTACCCAGCATGTACCCTATGTTTTTATGAAATATGCAATGTCAATGGATGGAAAA
    ATAGCCACTAAAACAAATCAATCCAAATGGATTACTGAAGAAGAAGCAAGAAAGCATGTG
    CATCAGTTACGACACCATGTTAGTGCAATTATGGTGGGAGTCAATACTGTTATTCAAGAC
    GATCCTTTGCTGACATGTAGATTGGAGGAAGGGAAAAATCCTATCCGTATCATATGCGAT
    ACACATTTACGAACTCCTCTTACCTCTAAAATCGTAAAAACAGCAAATGATATTAAAACT
    TACATTGCCACTTCCTCTGAAGACAAAAATAAAATGAAGCTATATCAAAATCATGGCTGT
    GAAATACTTTCCATAAAGAAAAAAGGCAATCATATAGACTTATCGAGTTTAATGCAACAT
    CTAGGAAACATGCAGATTGATAGCCTAGTTCTAGAAGGGGGCAGTCTAATGAATTGGAGT
    GCTTTGGAACAACAAATTGTTGATGAGCTGAAAATATATATTGCACCAAAAATTTTTGGA
    GGCAGTGCCAAGTTTCCTGTCGGAGGTGAAGGCATTTCTTTGCCAAATGACGCTATTAGA
    TTGAAACCTTATGCATTTTCTCAAATAGGAAATGACTATCTCATAGAAAGTGAAGTGATT
    TATCCATGTTCACAGGAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1101

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: JN057_RS01115 [old locus tag: JN057_00232 ]
  • symbol: RibD
  • description: bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD
  • length: 366
  • theoretical pI: 8.25755
  • theoretical MW: 40606.9
  • GRAVY: -0.17377

⊟Function[edit | edit source]

  • reaction:
    EC 3.5.4.26?  ExPASy
    Diaminohydroxyphosphoribosylaminopyrimidine deaminase 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + H2O = 5-amino-6-(5-phosphoribosylamino)uracil + NH3
    EC 1.1.1.193?  ExPASy
    5-amino-6-(5-phosphoribosylamino)uracil reductase 5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP+ = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NADPH
  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Riboflavin, FMN, and FAD riboflavin biosynthesis protein RibD (TIGR00326; EC 1.1.1.193,3.5.4.26; HMM-score: 357.7)
    and 3 more
    riboflavin-specific deaminase C-terminal domain (TIGR00227; EC 3.5.4.-; HMM-score: 222.6)
    diaminohydroxyphosphoribosylaminopyrimidine reductase (TIGR01508; EC 1.1.1.-; HMM-score: 159.1)
    ComE operon protein 2 (TIGR02571; HMM-score: 26.4)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    DHFred (CL0387) RibD_C; RibD C-terminal domain (PF01872; HMM-score: 181.1)
    and 5 more
    CDA (CL0109) dCMP_cyt_deam_1; Cytidine and deoxycytidylate deaminase zinc-binding region (PF00383; HMM-score: 76.1)
    MafB19-deam; MafB19-like deaminase (PF14437; HMM-score: 42.6)
    Inv-AAD; Invertebrate-AID/APOBEC-deaminase (PF18785; HMM-score: 21.6)
    no clan defined Helicase_IV_N; DNA helicase IV / RNA helicase N terminal (PF12462; HMM-score: 14.1)
    Tmem26; Transmembrane protein 26 (PF09772; HMM-score: 13.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9964
    • Cytoplasmic Membrane Score: 0.0015
    • Cell wall & surface Score: 0.0004
    • Extracellular Score: 0.0017
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.009063
    • TAT(Tat/SPI): 0.000494
    • LIPO(Sec/SPII): 0.00085
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001284090 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSDSKYMKLAIKLAQKGAGYVNPNPMVGAIIVKDNHIIGQGYHEFFGGPHAERNALKNCRKSPVGATLYVTLEPCCHFGKTPPCIDAIIDSGITRVVIGSLDCNPIVSGKGVKILEENNLQVTVGILENECLNLIKSFRKYITQHVPYVFMKYAMSMDGKIATKTNQSKWITEEEARKHVHQLRHHVSAIMVGVNTVIQDDPLLTCRLEEGKNPIRIICDTHLRTPLTSKIVKTANDIKTYIATSSEDKNKMKLYQNHGCEILSIKKKGNHIDLSSLMQHLGNMQIDSLVLEGGSLMNWSALEQQIVDELKIYIAPKIFGGSAKFPVGGEGISLPNDAIRLKPYAFSQIGNDYLIESEVIYPCSQE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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