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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 17-DEC-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae MDRSPN001
  • locus tag: MDRSPN_RS02425 [old locus tag: MDRSPN_00452 ]
  • pan locus tag?: PNEUPAN001394000
  • symbol: MDRSPN_RS02425
  • pan gene symbol?: blpH
  • synonym:
  • product: sensor histidine kinase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: MDRSPN_RS02425 [old locus tag: MDRSPN_00452 ]
  • symbol: MDRSPN_RS02425
  • product: sensor histidine kinase
  • replicon: chromosome
  • strand: +
  • coordinates: 456736..458076
  • length: 1341
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_AP018391 (456736..458076) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0469 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    ATGTATATTTTTTGGATTATATTGTATACACTTATTACTAATGGGCTAGAAATTGTCATT
    TTCTTTAAGGTAGATGGAATTGGTCTCACTTTTGAGAGGATTTTTAAGGCCTTTCTTTTG
    AAGATACTGTTGGCCTTTGTTTTTGTAATGATTGGCTATATGATAGGAAATGTTTACCTA
    TCTTATTTTATGGAACCCTTGTATGGCATAGGCTTGTCTTTCTTATTGTTAAGAGGGCTT
    CCTAAAAAACTCCTTTTCTTTTATGGTCTCTTTCCAATGATATTGGTGAATCTCTTTTAT
    AGAGGAGTCTCCTATTTTGTGCTTCCATTTTTGGGACAAGAGCAAGTATATGATGGCTAC
    TCATTTACTGGGTTATGTATAATAATTTTCAATTTCTTCATTTCTCTAGCCTTTTTGAAA
    TGGTTGGACTATGATTTTACTAGTTTGAGAAGGGAGATTCTAGATACAGGTTTTCAAAAG
    TCCCTGACTAAGATTAACTGGATAATGGGGGCTTACTATTTGGTGATACAAAGTCTGTCT
    TACTTTGAATATGAGCAAGGTATTCAATCAACGACTGTTCGCCATCTCATCCTAGTGTTT
    TACCTCCTATTTTTTATGGGGGTTATCAAGAAATTGGATACCTATTTGAAGGACAAACTC
    CATGATAGACTGGACCAAGAGCAGGTCTTGCGCTATAGAGATATGGAACGCTATAGTCGG
    CATATAGAGGAACTTTACAAGGAAGTAAGGAGTTTTCGCCATGACTACACCAACCTCTTG
    ACAAGTTTACGTCTGGGTATTGAAGAGGAGGATATGGAGCAGATAAAAGAGGTCTATGAC
    TTGGTCTTAAAGGATTCTAGTAAAAAATTGCAGGACAATAAATATGACCTTGGCCGATTG
    GTGAATGTTCGGGATCGTGCCCTCAAAAGTCTCCTAGCTGGAAAATTTATAAAAGCTAGA
    GAAAAGGACATTGTCTTTAATGTCGAAGTTCCTGAAGAGATTCAGGTTGAGGGGATGAGA
    CTGCTTGATTTTCTAACCATTGTGTCTATCCTTTGTGATAATGCTATTGAAGCGAGTGCA
    GAGGCCGGTCAACCTCATGTTTCAATTGCCTTTTTAAAAAGTGGAGCACAGGAGACCTTC
    ATCATCGAAAATTCCATCAAAGAAGAGGGCATAGATATTTCTGAAATCTTCTCCTTTGGA
    GTTAGTTCTAAAGGGGAGGAGAGAGGTGTCGGTCTCTATACCGTTATGAAGATTGTGGAA
    AGTTATCCCAATGCCAGTTTAAATACTACCTGTCAAGATCAAGTCTTTCGTCAGGTGCTT
    ACTATGATACCTACAGAATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1341

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: MDRSPN_RS02425 [old locus tag: MDRSPN_00452 ]
  • symbol: MDRSPN_RS02425
  • description: sensor histidine kinase
  • length: 446
  • theoretical pI: 5.23339
  • theoretical MW: 51995.4
  • GRAVY: 0.237668

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.13.3?  ExPASy
    Histidine kinase ATP + protein L-histidine = ADP + protein N-phospho-L-histidine
  • TIGRFAM:
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    His_Kinase_A (CL0025) HATPase_c_5; GHKL domain (PF14501; HMM-score: 48.3)
    and 5 more
    HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF02518; HMM-score: 20.1)
    no clan defined DUF4736; Domain of unknown function (DUF4736) (PF15883; HMM-score: 17.5)
    SPOB_a; Sensor_kinase_SpoOB-type, alpha-helical domain (PF14689; HMM-score: 12)
    DUF4108; Protein of unknown function (DUF4108) (PF13390; HMM-score: 11.1)
    Ctr; Ctr copper transporter family (PF04145; HMM-score: 10.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 7
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0008
    • Cytoplasmic Membrane Score: 0.9933
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.0057
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.000835
    • TAT(Tat/SPI): 0.000041
    • LIPO(Sec/SPII): 0.025212
  • predicted transmembrane helices (TMHMM): 7

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000275284 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MYIFWIILYTLITNGLEIVIFFKVDGIGLTFERIFKAFLLKILLAFVFVMIGYMIGNVYLSYFMEPLYGIGLSFLLLRGLPKKLLFFYGLFPMILVNLFYRGVSYFVLPFLGQEQVYDGYSFTGLCIIIFNFFISLAFLKWLDYDFTSLRREILDTGFQKSLTKINWIMGAYYLVIQSLSYFEYEQGIQSTTVRHLILVFYLLFFMGVIKKLDTYLKDKLHDRLDQEQVLRYRDMERYSRHIEELYKEVRSFRHDYTNLLTSLRLGIEEEDMEQIKEVYDLVLKDSSKKLQDNKYDLGRLVNVRDRALKSLLAGKFIKAREKDIVFNVEVPEEIQVEGMRLLDFLTIVSILCDNAIEASAEAGQPHVSIAFLKSGAQETFIIENSIKEEGIDISEIFSFGVSSKGEERGVGLYTVMKIVESYPNASLNTTCQDQVFRQVLTMIPTE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

A de Saizieu, C Gardès, N Flint, C Wagner, M Kamber, T J Mitchell, W Keck, K E Amrein, R Lange
Microarray-based identification of a novel Streptococcus pneumoniae regulon controlled by an autoinduced peptide.
J Bacteriol: 2000, 182(17);4696-703
[PubMed:10940007] [WorldCat.org] [DOI] (P p)Wei-Yun Wholey, Travis J Kochan, David N Storck, Suzanne Dawid
Coordinated Bacteriocin Expression and Competence in Streptococcus pneumoniae Contributes to Genetic Adaptation through Neighbor Predation.
PLoS Pathog: 2016, 12(2);e1005413
[PubMed:26840124] [WorldCat.org] [DOI] (I e)Morten Kjos, Eric Miller, Jelle Slager, Frank B Lake, Oliver Gericke, Ian S Roberts, Daniel E Rozen, Jan-Willem Veening
Expression of Streptococcus pneumoniae Bacteriocins Is Induced by Antibiotics via Regulatory Interplay with the Competence System.
PLoS Pathog: 2016, 12(2);e1005422
[PubMed:26840404] [WorldCat.org] [DOI] (I e)

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