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serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 24-APR-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae G54
  • locus tag: SPG_RS02420 [old locus tag: SPG_0477 ]
  • pan locus tag?: PNEUPAN001394000
  • symbol: SPG_RS02420
  • pan gene symbol?: blpH
  • synonym:
  • product: sensor histidine kinase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPG_RS02420 [old locus tag: SPG_0477 ]
  • symbol: SPG_RS02420
  • product: sensor histidine kinase
  • replicon: chromosome
  • strand: +
  • coordinates: 470956..472296
  • length: 1341
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    ATGAACATTGCTTGGATATTGTTGTATACACTTGTTACTAATGGACTAGAAATTGTCATC
    TTCTTTAAGGTGGATGGAATTGATCTTGCTTTCGAGAGGATTTTTAAGGCCTTTCTTTTT
    AAGATACTGTTGGCCTTTGTTTTTGTGATGATTAGCTATATAGTAGGAAATGTTTACCTA
    TCTTATTTTATGGAACCCTTGTACGGCATAGGCTTATCTTTCTTATTATTGAGAGGGCTT
    CCTAAAAAACTCCTTTTCTTTTATGGTCTCTTTCCAATGATATTGGTGAATCTCTTTTAT
    AGAGGAGTCTCCTATTTTGTGCTTCCATTTTTGGGACAAGGGCAAGTATATGATGGCTAC
    TCATTTACTGGGTTATGTATAATAATTTTCAATTTCTTCATTTCTCTAGCTTTTTTGAAA
    TGGTTGGACTACGATTTTACTAGCTTGAGAAAGGAGATTCTCGATAAAGCCTTTCAAAAG
    TCCCTGACTCAGATTAACTGGATAATGGGTGGCTACTATCTAGTCATGGAAAGTCTGTCT
    TTTTTTGAATATGAACAAAGTATTCAATCAAAGACTGTTCGCCATCTCATCCTAGTCTTT
    TACCTACTCTTTTTTATGGGGGTTATCAAGAAATTGGATACCTATTTGAAGGAAAAACTC
    TATGAGAGATTGGAACAAGAGCAGGCCCTGCGCTATAGAGATATGGAACGCTATAGTCGG
    CATATAGAGGAGCTTTACAAGGAAGTACGGAGTTTTCGCCATGATTATACCAACCTCTTG
    ACTAGCTTACGTCTGGGCATTGAAGAGGAGGATATGGAGCAGATAAAAGAGGTCTATGGC
    TCCGTCTTAAAGGATTCCAGTCAGAAATTGCAGAACAATAAATATGACCTGGGCAGATTG
    GTAAATATTCGTGATAAAGCCCTCAAAAGTCTTNTAGCAGGGAAATTTTTAAAAGCCAGA
    GATAAGAACATTGTCTTTAATGTCGAAGTTCCTGAGGAGATTCAGGTCGAGGGGATGAGT
    CTACTTGATTTTCTAACCATTGTGTCTATCCTTTGTGACAATGCTATTGAAGCCAGTGTG
    GAAGCTAGTCAACCTCATGTTTCAATCGCCTTTTTAAAAAATGGAGCACAGGAGACCTTT
    ATCATCGAAAACTCCATCAAAGAAGAGGGCATCGATATTTCTGAAATCTTCTCCTTTGGA
    GCCAGTTCTAAAGGGGAGGAGAGAGGAGTTGGTCTCTATACCGTCATGAAGATTGTGGAA
    AGCCATCCTAATACCAGTCTAAATACCACCTGTCAAAATCAAGTCTTTCGTCAGGTACTT
    ACTGTGATACATACAGAATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1341

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPG_RS02420 [old locus tag: SPG_0477 ]
  • symbol: SPG_RS02420
  • description: sensor histidine kinase
  • length: 446
  • theoretical pI: 5.77378
  • theoretical MW: 51715
  • GRAVY: 0.20809

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.13.3?  ExPASy
    Histidine kinase ATP + protein L-histidine = ADP + protein N-phospho-L-histidine
  • TIGRFAM:
  • TheSEED: see SPG_0477
  • PFAM:
    His_Kinase_A (CL0025) HATPase_c_5; GHKL domain (PF14501; HMM-score: 45.6)
    and 3 more
    HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF02518; HMM-score: 19.9)
    no clan defined DUF4736; Domain of unknown function (DUF4736) (PF15883; HMM-score: 19.5)
    SPOB_a; Sensor_kinase_SpoOB-type, alpha-helical domain (PF14689; HMM-score: 14.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 5
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.001
    • Cytoplasmic Membrane Score: 0.9863
    • Cell wall & surface Score: 0.0004
    • Extracellular Score: 0.0124
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.00094
    • TAT(Tat/SPI): 0.000046
    • LIPO(Sec/SPII): 0.017712
  • predicted transmembrane helices (TMHMM): 6

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001017637 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MNIAWILLYTLVTNGLEIVIFFKVDGIDLAFERIFKAFLFKILLAFVFVMISYIVGNVYLSYFMEPLYGIGLSFLLLRGLPKKLLFFYGLFPMILVNLFYRGVSYFVLPFLGQGQVYDGYSFTGLCIIIFNFFISLAFLKWLDYDFTSLRKEILDKAFQKSLTQINWIMGGYYLVMESLSFFEYEQSIQSKTVRHLILVFYLLFFMGVIKKLDTYLKEKLYERLEQEQALRYRDMERYSRHIEELYKEVRSFRHDYTNLLTSLRLGIEEEDMEQIKEVYGSVLKDSSQKLQNNKYDLGRLVNIRDKALKSLXAGKFLKARDKNIVFNVEVPEEIQVEGMSLLDFLTIVSILCDNAIEASVEASQPHVSIAFLKNGAQETFIIENSIKEEGIDISEIFSFGASSKGEERGVGLYTVMKIVESHPNTSLNTTCQNQVFRQVLTVIHTE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

A de Saizieu, C Gardès, N Flint, C Wagner, M Kamber, T J Mitchell, W Keck, K E Amrein, R Lange
Microarray-based identification of a novel Streptococcus pneumoniae regulon controlled by an autoinduced peptide.
J Bacteriol: 2000, 182(17);4696-703
[PubMed:10940007] [WorldCat.org] [DOI] (P p)Wei-Yun Wholey, Travis J Kochan, David N Storck, Suzanne Dawid
Coordinated Bacteriocin Expression and Competence in Streptococcus pneumoniae Contributes to Genetic Adaptation through Neighbor Predation.
PLoS Pathog: 2016, 12(2);e1005413
[PubMed:26840124] [WorldCat.org] [DOI] (I e)Morten Kjos, Eric Miller, Jelle Slager, Frank B Lake, Oliver Gericke, Ian S Roberts, Daniel E Rozen, Jan-Willem Veening
Expression of Streptococcus pneumoniae Bacteriocins Is Induced by Antibiotics via Regulatory Interplay with the Competence System.
PLoS Pathog: 2016, 12(2);e1005422
[PubMed:26840404] [WorldCat.org] [DOI] (I e)

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