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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 17-DEC-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae MDRSPN001
  • locus tag: MDRSPN_RS05865 [old locus tag: MDRSPN_01112 ]
  • pan locus tag?: PNEUPAN001840000
  • symbol: MDRSPN_RS05865
  • pan gene symbol?: iscS_1
  • synonym:
  • product: cysteine desulfurase family protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: MDRSPN_RS05865 [old locus tag: MDRSPN_01112 ]
  • symbol: MDRSPN_RS05865
  • product: cysteine desulfurase family protein
  • replicon: chromosome
  • strand: -
  • coordinates: 1133941..1135083
  • length: 1143
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_AP018391 (1133941..1135083) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0776 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    ATGATTTACTTTGATAATTCAGCGACGACCAAGCCTTATCCTGAAGCCCTTGAAACCTAT
    ATGCAGGTCGCTTCAAAAATTTTAGGAAACCCATCTAGTCTCCATCGTTTGGGAGACCAA
    GCAACACGAATCTTAGATGCTTCTCGCCAACAGATTGCAGATTTAGTCGGTAAGAAAAGC
    GATGAAATCTTCTTTACCTCTGGTGGAACAGAAGGGGATAACTGGGTTATCAAGGGTGTG
    GCCTTTGAAAAAGCTCAGTTTGGCAAGCACATCATTGTTTCAGCCATTGAACATCCAGCA
    GTCAAAGAGTCAGCCCTCTGGTTGAAAAGTCAAGGATTTGAAGTGGATTTTGCTCCAGTT
    GATAAGAAAGGCTTGGTCGATGTTGAGGCGTTAGCAGGTTTGATACGGCCTGATACAATC
    CTCGTTTCCATCATGGCTGTGAACAATGAAATCGGCTCTATCCAACCTATTGAGGCTATT
    TCAGAATTCTTGGCAGACAAGCCGACTATTTCCTTCCACGTTGATGCGGTTCAGGCGCTT
    GCCAAAATTCCGACTGAAAAGTATCTGACAGAACGGGTGGATTGCGCGACCTTCTCGAGT
    CATAAATTTCATGGTGTCCGTGGTGTTGGCTTTGTCTATATCAAATCTGGCAAGAAGATT
    ACACCTCTTCTTACAGGTGGTGGCCAGGAGCGAGATTATCGTTCGACAACTGAAAATGTG
    GCAGGGATTGCAGCGACAGCCAAGGCTCTTCGTTTATCTATGGAAAAGCTAGATATCTTT
    AGGAGCAAGACTGGGCAGATGAAGGCAGTGATTCACCAAGCTCTTCTGAACTATCCGGAT
    ATTTTTGTCTTTTCAGATGAGGAAGACTTTGCACCTCATATTCTGACTTTTGGAATCAAA
    GGTGTTCGAGGTGAAGTCATCGTTCACGCCTTTGAAGACTATGATATTTTTATCTCAACA
    ACCTCAGCTTGTTCATCTAAGGCAGGAAAACCAGCTGGTACCTTGATTGCCATGGGAGTG
    GACAAAGATAAGGCCAAGTCAGCTGTGCGTCTTAGCCTAGACTTGGAAAATGATATGAGT
    CAGGTCGAGCAGTTTTTGACCAAGTTAAAATTGATTTACAATCAAACTAGAAAAGTAAGA
    TAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1143

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: MDRSPN_RS05865 [old locus tag: MDRSPN_01112 ]
  • symbol: MDRSPN_RS05865
  • description: cysteine desulfurase family protein
  • length: 380
  • theoretical pI: 7.02779
  • theoretical MW: 41677.5
  • GRAVY: -0.0818421

⊟Function[edit | edit source]

  • TIGRFAM:
    cysteine desulfurase NifS (TIGR03402; EC 2.8.1.7; HMM-score: 348)
    Genetic information processing DNA metabolism Restriction/modification cysteine desulfurase DndA (TIGR03235; EC 2.8.1.7; HMM-score: 304.2)
    cysteine desulfurase, NifS family (TIGR03403; EC 2.8.1.7; HMM-score: 288.7)
    and 9 more
    Genetic information processing Protein synthesis tRNA and rRNA base modification cysteine desulfurase IscS (TIGR02006; EC 2.8.1.7; HMM-score: 254)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other cysteine desulfurase IscS (TIGR02006; EC 2.8.1.7; HMM-score: 254)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other cysteine desulfurase, SufS family (TIGR01979; HMM-score: 125.1)
    Unknown function Enzymes of unknown specificity cysteine desulfurase family protein (TIGR01977; HMM-score: 123)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other cysteine desulfurase, catalytic subunit CsdA (TIGR03392; EC 2.8.1.7; HMM-score: 69.7)
    Unknown function Enzymes of unknown specificity cysteine desulfurase family protein (TIGR01976; HMM-score: 64.2)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Glutathione and analogs ergothioneine biosynthesis PLP-dependent enzyme EgtE (TIGR04343; EC 4.4.-.-; HMM-score: 56.1)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other tyrosine decarboxylase MnfA (TIGR03812; EC 4.1.1.25; HMM-score: 41.7)
    2-aminoethylphosphonate aminotransferase (TIGR03301; EC 2.6.1.-; HMM-score: 18.5)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    PLP_aminotran (CL0061) Aminotran_5; Aminotransferase class-V (PF00266; HMM-score: 225.4)
    and 2 more
    DegT_DnrJ_EryC1; DegT/DnrJ/EryC1/StrS aminotransferase family (PF01041; HMM-score: 27.2)
    Beta_elim_lyase; Beta-eliminating lyase (PF01212; HMM-score: 19.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9961
    • Cytoplasmic Membrane Score: 0.0008
    • Cell wall & surface Score: 0.0008
    • Extracellular Score: 0.0023
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.006068
    • TAT(Tat/SPI): 0.000514
    • LIPO(Sec/SPII): 0.000789
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000638922 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MIYFDNSATTKPYPEALETYMQVASKILGNPSSLHRLGDQATRILDASRQQIADLVGKKSDEIFFTSGGTEGDNWVIKGVAFEKAQFGKHIIVSAIEHPAVKESALWLKSQGFEVDFAPVDKKGLVDVEALAGLIRPDTILVSIMAVNNEIGSIQPIEAISEFLADKPTISFHVDAVQALAKIPTEKYLTERVDCATFSSHKFHGVRGVGFVYIKSGKKITPLLTGGGQERDYRSTTENVAGIAATAKALRLSMEKLDIFRSKTGQMKAVIHQALLNYPDIFVFSDEEDFAPHILTFGIKGVRGEVIVHAFEDYDIFISTTSACSSKAGKPAGTLIAMGVDKDKAKSAVRLSLDLENDMSQVEQFLTKLKLIYNQTRKVR

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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