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serotype 4
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serotype 6B
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serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
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SP49
serotype 19A
SPN032672
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serotype 3
SPN034183
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SPN994038
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SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
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serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 24-APR-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae G54
  • locus tag: SPG_RS04065 [old locus tag: SPG_0805 ]
  • pan locus tag?: PNEUPAN001840000
  • symbol: SPG_RS04065
  • pan gene symbol?: iscS_1
  • synonym:
  • product: cysteine desulfurase family protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPG_RS04065 [old locus tag: SPG_0805 ]
  • symbol: SPG_RS04065
  • product: cysteine desulfurase family protein
  • replicon: chromosome
  • strand: +
  • coordinates: 779468..780610
  • length: 1143
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    ATGATTTACTTTGATAATTCAGCGACGACCAAGCCTTATCCTGAAGCCCTTGAAACCTAT
    ATGCAGGTCGCTTCAAAAATTTTAGGAAACCCATCTAGTCTCCATAGTTTGGGAGACCAA
    GCAACACGAATCTTAGATGCTTCTCGCCAACAGATTGCAGATTTAATCGGTAAGAAAAGC
    GATGAAATCTTCTTTACCTCTGGTGGAACAGAAGGGGATAACTGGGTTATCAAGGGTGTG
    GCCTTTGAAAAAGCTCAGTTTGGCAAGCACATCATTGTTTCAGCCATTGAACATCCAGCA
    GTCAAAGAGTCAGCCCTCTGGTTGAAAAGTCAAGGATTTGAAGTGGATTTTGCTCCAGTT
    GATAAGAAAGGCTTGGTCGATGTTGAGGCGTTAGCAGGTTTGATACGGCCTGATACAATC
    CTCGTTTCTATCATGGCTGTGAACAATGAAATCGGCTCTATCCAACCTATTGAGGCTATT
    TCAGAATTCTTGGCAGACAAGCCGACTATTTCCTTCCACGTTGATGGGGTTCAGGCGCTT
    ACCAAGATTCCGACTGAAAAGTATCTGACAGAACGAGTGGATTTTGCGACTTTCTCTAGT
    CACAAGTTCCACGGGGTTCGAGGTGTTGGCTTTGTCTATATCAAATCTGGCAAGAAGATT
    ACACCTCTTCTTACAGGTGGTGGCCAGGAGCGAGATTATCGTTCGACAACTGAAAATGTG
    GCAGGGATTGCAGCGACAGCCAAGGCCCTCCGTTTGTCTATGGAAAAGCTAGATATCTTT
    AGGAGCAAGACTGGGCAGATGAAGGCAGTGATTCGCCAAGCTCTTCTGAACCATCCGGAT
    ATTTTTGTCTTTTCAGATGAGGAAAACTTTGCACCTCATATTCTGACTTTTGGAATCAAA
    GGTGTTCGAGGTGAAGTCATCGTTCACGCCTTTGAAGACTATGATATTTTCATCTCAACA
    ACCTCAGCTTGTTCATCTAAGGCAGGAAAACCAGCCGGTACCTTGATTGCCATGGGAGTG
    GACAAAGATAAGGCCAAGTCAGCTGTGCGTCTTAGCCTAGACTTGGAAAATGATATGAGT
    CAGGTCGAGCAGTTTTTGACCAAGTTAAAATTGATTTACAATCAAACTAGAAAAGTAAGA
    TAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1143

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPG_RS04065 [old locus tag: SPG_0805 ]
  • symbol: SPG_RS04065
  • description: cysteine desulfurase family protein
  • length: 380
  • theoretical pI: 7.34637
  • theoretical MW: 41674.5
  • GRAVY: -0.0913158

⊟Function[edit | edit source]

  • TIGRFAM:
    cysteine desulfurase NifS (TIGR03402; EC 2.8.1.7; HMM-score: 348.2)
    Genetic information processing DNA metabolism Restriction/modification cysteine desulfurase DndA (TIGR03235; EC 2.8.1.7; HMM-score: 303.4)
    cysteine desulfurase, NifS family (TIGR03403; EC 2.8.1.7; HMM-score: 287.5)
    and 9 more
    Genetic information processing Protein synthesis tRNA and rRNA base modification cysteine desulfurase IscS (TIGR02006; EC 2.8.1.7; HMM-score: 253)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other cysteine desulfurase IscS (TIGR02006; EC 2.8.1.7; HMM-score: 253)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other cysteine desulfurase, SufS family (TIGR01979; HMM-score: 129.8)
    Unknown function Enzymes of unknown specificity cysteine desulfurase family protein (TIGR01977; HMM-score: 120.5)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other cysteine desulfurase, catalytic subunit CsdA (TIGR03392; EC 2.8.1.7; HMM-score: 76.6)
    Unknown function Enzymes of unknown specificity cysteine desulfurase family protein (TIGR01976; HMM-score: 62.3)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Glutathione and analogs ergothioneine biosynthesis PLP-dependent enzyme EgtE (TIGR04343; EC 4.4.-.-; HMM-score: 51.7)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other tyrosine decarboxylase MnfA (TIGR03812; EC 4.1.1.25; HMM-score: 39.5)
    2-aminoethylphosphonate aminotransferase (TIGR03301; EC 2.6.1.-; HMM-score: 19.1)
  • TheSEED: see SPG_0805
  • PFAM:
    PLP_aminotran (CL0061) Aminotran_5; Aminotransferase class-V (PF00266; HMM-score: 227.8)
    and 3 more
    DegT_DnrJ_EryC1; DegT/DnrJ/EryC1/StrS aminotransferase family (PF01041; HMM-score: 23.4)
    Beta_elim_lyase; Beta-eliminating lyase (PF01212; HMM-score: 19.8)
    no clan defined ScsC_N; Copper resistance protein ScsC N-terminal domain (PF18312; HMM-score: 12.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9954
    • Cytoplasmic Membrane Score: 0.0012
    • Cell wall & surface Score: 0.0009
    • Extracellular Score: 0.0026
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.008205
    • TAT(Tat/SPI): 0.000676
    • LIPO(Sec/SPII): 0.00088
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000638925 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MIYFDNSATTKPYPEALETYMQVASKILGNPSSLHSLGDQATRILDASRQQIADLIGKKSDEIFFTSGGTEGDNWVIKGVAFEKAQFGKHIIVSAIEHPAVKESALWLKSQGFEVDFAPVDKKGLVDVEALAGLIRPDTILVSIMAVNNEIGSIQPIEAISEFLADKPTISFHVDGVQALTKIPTEKYLTERVDFATFSSHKFHGVRGVGFVYIKSGKKITPLLTGGGQERDYRSTTENVAGIAATAKALRLSMEKLDIFRSKTGQMKAVIRQALLNHPDIFVFSDEENFAPHILTFGIKGVRGEVIVHAFEDYDIFISTTSACSSKAGKPAGTLIAMGVDKDKAKSAVRLSLDLENDMSQVEQFLTKLKLIYNQTRKVR

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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