PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 14-DEC-2020

⊟Summary

• organism: Streptococcus pneumoniae MDRSPN001
• locus tag: MDRSPN_RS10090 [old locus tag: MDRSPN_01919 ]
• pan locus tag^?: PNEUPAN003714000
• symbol: MDRSPN_RS10090
• pan gene symbol^?: malX
• synonym:
• product: extracellular solute-binding protein

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: MDRSPN_RS10090 [old locus tag: MDRSPN_01919 ]
• symbol: MDRSPN_RS10090
• product: extracellular solute-binding protein
• replicon: chromosome
• strand: +
• coordinates: 1899031..1900302
• length: 1272
• essential: unknown

⊟Accession numbers

• Location: NZ_AP018391 (1899031..1900302) NCBI
• BioCyc:
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_1934 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  1021
  1081
  1141
  1201
  1261
  
  ATGTCATCTAAATTTATGAAGAGCACTGCGGTGCTTGGAACTGCTACACTTGCTAGCTTG
  CTTTTGGTAGCTTGCGGAAGCAAAACTGCTGATAAGCCTGCTGATTCTGGTTCATCTGAA
  GTCAAAGAACTCACTGTATATGTAGACGAGGGATATAAGAGCTATATTGAAGAGGTTGCT
  AAAGCTTATGAAAAAGAAGCTGGAGTAAAAGTCACTCTTAAAACTGGTGATGCTCTAGGA
  GGTCTTGATAAACTTTCTCTTGACAACCAATCTGGTAATGTCCCTGATGTTATGATGGCT
  CCATACGACCGTGTAGGTAGCCTTGGTTCTGACGGACAACTTTCAGAAGTGAAATTGAGC
  GATGGTGCTAAAACAGACGACACAACTAAATCTCTTGTAACAGCTGCTAATGGTAAAGTT
  TACGGTGCTCCTGCCGTTATCGAGTCACTTGTTATGTACTACAACAAAGACTTGGTGAAA
  GATGCTCCAAAAACATTTGCTGACTTGGAAAACCTTGCTAAAGATAGCAAATACGCATTC
  GCTGGTGAAGATGGTAAAACTACTGCCTTCCTAGCTGACTGGACAAACTTCTACTATGCA
  TACGGACTTCTTGCTGGTAACGGCGGATACGTATTCGGTCAAAATGGTAAAGATCCTAAA
  GACATCGGTCTTGCCAACGACGGTTCTATCGCAGGTATCAACTACGCTAAATCTTGGTAT
  GAAAAATGGCCTAAAGGTATGCAAGATACAGAAGGTGCTGGAAACTTGATCCAAACTCAT
  TTCCAAGAAGGTAAAACAGCTGCTATCATCGACGGACCTTGGAAAGCTCAAGCCTTCAAA
  GATGCTAAAGTAAACTACGGAGTTGCAACTATTCCAACTCTTCCAAATGGAAAAGAATAT
  GCTGCATTCGGTGGTGGTAAAGCCTGGGTCATCCCTCAAGCCGTTAAGAACCTTGAAGCC
  GCACAAAAATTTGTAGACTTCCTTGTTTCAACTGAACAACAAAAAGCCTTATACGATAAG
  ACTAATGAAATCCCAGCTAATACTGAAGCTCGTTCATACGCTGAAGGTAAAAACGATGAG
  TTGACAACAGCTGTTATCAAACAGTTCAAGAGCACTCAGCCACTGCCAAACATCTCTCAA
  ATGTCTGCAGTTTGGGATCCAGCGAAAAACATGCTCTTTGATGCTGTAAGTGGTCAAAAA
  GATGCGAAAACATCTGCTAACGATGCTGTAACATTGATTAAAGAAACAATCAAACAAAAA
  TTTGGTGAATAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  840
  900
  960
  1020
  1080
  1140
  1200
  1260
  1272
  

⊟Protein

⊟General

• locus tag: MDRSPN_RS10090 [old locus tag: MDRSPN_01919 ]
• symbol: MDRSPN_RS10090
• description: extracellular solute-binding protein
• length: 423
• theoretical pI: 4.89895
• theoretical MW: 45290.6
• GRAVY: -0.371395

⊟Function

• TIGRFAM:
  Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids carbohydrate ABC transporter substrate-binding protein, CPR_0540 family (TIGR03850; HMM-score: 63.5)
  and 3 more
  2-aminoethylphosphonate ABC transporter, 2-aminoethylphosphonate binding protein (TIGR03227; HMM-score: 33.6)
  Metabolism Transport and binding proteins Other ABC transporter periplasmic binding protein, thiB subfamily (TIGR01254; HMM-score: 18)
  Metabolism Transport and binding proteins Anions phosphate binding protein (TIGR02136; HMM-score: 14.3)
• TheSEED: data available for D39, Hungary19A-6, TIGR4
• PFAM:
  PBP (CL0177) SBP_bac_8; Bacterial extracellular solute-binding protein (PF13416; HMM-score: 147.3)
  SBP_bac_1; Bacterial extracellular solute-binding protein (PF01547; HMM-score: 129.2)
  and 2 more
  SBP_bac_11; Bacterial extracellular solute-binding protein (PF13531; HMM-score: 38.9)
  SBP_bac_6; Bacterial extracellular solute-binding protein (PF13343; HMM-score: 31.6)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: unknown (no significant prediction)
  • Cytoplasmic Score: 2.5
  • Cytoplasmic Membrane Score: 2.5
  • Cellwall Score: 2.5
  • Extracellular Score: 2.5
  • Internal Helix: 1
• SignalP: Signal peptide LIPO(Sec/SPII) length 24 aa
  • SP(Sec/SPI): 0.00194
  • TAT(Tat/SPI): 0.000257
  • LIPO(Sec/SPII): 0.997528
  • Cleavage Site: CS pos: 24-25. LVA-CG. Pr: 0.9964
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_120164298 NCBI
• UniProt:

⊟Protein sequence

• MSSKFMKSTAVLGTATLASLLLVACGSKTADKPADSGSSEVKELTVYVDEGYKSYIEEVAKAYEKEAGVKVTLKTGDALGGLDKLSLDNQSGNVPDVMMAPYDRVGSLGSDGQLSEVKLSDGAKTDDTTKSLVTAANGKVYGAPAVIESLVMYYNKDLVKDAPKTFADLENLAKDSKYAFAGEDGKTTAFLADWTNFYYAYGLLAGNGGYVFGQNGKDPKDIGLANDGSIAGINYAKSWYEKWPKGMQDTEGAGNLIQTHFQEGKTAAIIDGPWKAQAFKDAKVNYGVATIPTLPNGKEYAAFGGGKAWVIPQAVKNLEAAQKFVDFLVSTEQQKALYDKTNEIPANTEARSYAEGKNDELTTAVIKQFKSTQPLPNISQMSAVWDPAKNMLFDAVSGQKDAKTSANDAVTLIKETIKQKFGE

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• data available for TIGR4

⊟Expression data

• PneumoExpress for strain D39V: SPV_1934 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications