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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_2297 [new locus tag: SPH_RS11260 ]
  • pan locus tag?: PNEUPAN003714000
  • symbol: SPH_2297
  • pan gene symbol?: malX
  • synonym:
  • product: maltose/maltodextrin-binding protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_2297 [new locus tag: SPH_RS11260 ]
  • symbol: SPH_2297
  • product: maltose/maltodextrin-binding protein
  • replicon: chromosome
  • strand: +
  • coordinates: 2106011..2107282
  • length: 1272
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    ATGTCATCTAAATTCACGAAGAGCGCTGCTGTGCTTGGAACTGTTACACTTGCTAGCTTG
    CTTTTGGTAGCTTGCGGAAGCAAAACTGCTGATAAGCCTGCTGATTCTGGTTCATCTGAA
    GCCAAAGAACTCACTGTATATGTAGACGAAGGATATAAGAGCTATATTGAAGAGATTGCT
    AAAGCTTATGAAAAAGAAGCTGGCGTAAAAATTACTCTTAAAACTGGTGATGCTCTAGGA
    GGTCTTGATAAACTTTCACTTGACAACCAATCTGGTAATGTCCCTGATATTATGATGGCT
    CCATACGACCGTGTAGGTAGCCTTGGTTCTGACGGACAACTTTCAGAAGTGAAATTGAGC
    GATGGTGCTAAAACAGACGACACAACTAAATCTCTTGTAACTGCTGCTAATGGTAAAGTT
    TACGGTGCTCCTGCCGTGATCGAGTCACTTGTTATGTACTACAACAAAGACTTGGTAAAA
    GATGCTCCAAAAACATTTACTGACTTGGAAAACCTTGCTAAAGATAGCAAATATGCCTTC
    GCTGGAGAAGATGGCAAAACTACTGCCTTCCTAGCTGACTGGACAAACTTCTACTATGCA
    TACGGACTTCTTGCTGGTAACGGCGGATACGTATTCGGACAAAACGGTAAAGATCCTAAA
    GACATCGGTCTTGCCAACGACGGTTCTATCGCAGGTATCAACTACGCTAAATCTTGGTAT
    GAAAAATGGCCTAAAGGTATGCAAGATACAGAAGGTGCTGGAAACTTGATCCAAACTCAT
    TTCCAAGAAGGTAAAACAGCTGCTATCATCGACGGACCTTGGAAAGCTCAAGCTTTCAAA
    GATGCTAAAGTAAACTACGGAGTTGCAACTATTCCAACTCTTCCAAATGGAAAAGAATAT
    GCTGCATTCGGTGGTGGTAAAGCCTGGGTCATCCCTCAAGCCGTTAAGAACCTTGAAGCC
    GCACAAAAATTTGTAGACTTCCTTGTTTCAACTGAACAACAAAAAGCCTTATACGATAAG
    ACTAATGAAATCCCAGCTAATACTGAAGCTCGTTCATACGCTGAAGGTAAAAACGATGAG
    TTGACAACAGCTGTTATCAAACAGTTCAAGAGCACTCAGCCACTGCCAAACATCTCTCAA
    ATGTCTGCAGTTTGGGATCCAGCGAAAAACATGCTCTTTGATGCTGTAAGTGGTCAAAAA
    GATGCTAAAACAGCTGCTAACGATGCTGTAACATTGATTAAAGAAACAATCAAACAAAAA
    TTTGGTGAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1272

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_2297 [new locus tag: SPH_RS11260 ]
  • symbol: SPH_2297
  • description: maltose/maltodextrin-binding protein
  • length: 423
  • theoretical pI: 4.89895
  • theoretical MW: 45286.6
  • GRAVY: -0.369267

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids carbohydrate ABC transporter substrate-binding protein, CPR_0540 family (TIGR03850; HMM-score: 61.5)
    and 2 more
    2-aminoethylphosphonate ABC transporter, 2-aminoethylphosphonate binding protein (TIGR03227; HMM-score: 31.5)
    Metabolism Transport and binding proteins Other ABC transporter periplasmic binding protein, thiB subfamily (TIGR01254; HMM-score: 19.2)
  • TheSEED  :
    • Maltose/maltodextrin ABC transporter, substrate binding periplasmic protein MalE
    Carbohydrates Di- and oligosaccharides Maltose and Maltodextrin Utilization  Maltose/maltodextrin ABC transporter, substrate binding periplasmic protein MalE
    and 2 more
    Carbohydrates Polysaccharides Alpha-Amylase locus in Streptocococcus  Maltose/maltodextrin ABC transporter, substrate binding periplasmic protein MalE
    Motility and Chemotaxis Motility and Chemotaxis - no subcategory Bacterial Chemotaxis  Maltose/maltodextrin ABC transporter, substrate binding periplasmic protein MalE
  • PFAM:
    PBP (CL0177) SBP_bac_8; Bacterial extracellular solute-binding protein (PF13416; HMM-score: 145.5)
    SBP_bac_1; Bacterial extracellular solute-binding protein (PF01547; HMM-score: 127.8)
    and 2 more
    SBP_bac_11; Bacterial extracellular solute-binding protein (PF13531; HMM-score: 38.6)
    SBP_bac_6; Bacterial extracellular solute-binding protein (PF13343; HMM-score: 30.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.17
    • Cytoplasmic Membrane Score: 9.51
    • Cellwall Score: 0.16
    • Extracellular Score: 0.15
    • Internal Helix: 1
  • SignalP: Signal peptide LIPO(Sec/SPII) length 24 aa
    • SP(Sec/SPI): 0.001635
    • TAT(Tat/SPI): 0.000415
    • LIPO(Sec/SPII): 0.99768
    • Cleavage Site: CS pos: 24-25. LVA-CG. Pr: 0.9970
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MSSKFTKSAAVLGTVTLASLLLVACGSKTADKPADSGSSEAKELTVYVDEGYKSYIEEIAKAYEKEAGVKITLKTGDALGGLDKLSLDNQSGNVPDIMMAPYDRVGSLGSDGQLSEVKLSDGAKTDDTTKSLVTAANGKVYGAPAVIESLVMYYNKDLVKDAPKTFTDLENLAKDSKYAFAGEDGKTTAFLADWTNFYYAYGLLAGNGGYVFGQNGKDPKDIGLANDGSIAGINYAKSWYEKWPKGMQDTEGAGNLIQTHFQEGKTAAIIDGPWKAQAFKDAKVNYGVATIPTLPNGKEYAAFGGGKAWVIPQAVKNLEAAQKFVDFLVSTEQQKALYDKTNEIPANTEARSYAEGKNDELTTAVIKQFKSTQPLPNISQMSAVWDPAKNMLFDAVSGQKDAKTAANDAVTLIKETIKQKFGE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulators: MalR* (repression) regulon, CcpA regulon
    MalR*(TF)important in Maltose utilization, Maltodextrin utilization; RegPrecise 
    CcpA(TF)important in Global catabolite repression; RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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