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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 02-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae ST556
  • locus tag: MYY_RS02715 [old locus tag: MYY_0533 ]
  • pan locus tag?: PNEUPAN001319000
  • symbol: rrgB
  • pan gene symbol?: rrgB
  • synonym:
  • product: PI-1 pilus major pilin RrgB

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: MYY_RS02715 [old locus tag: MYY_0533 ]
  • symbol: rrgB
  • product: PI-1 pilus major pilin RrgB
  • replicon: chromosome
  • strand: +
  • coordinates: 505455..507452
  • length: 1998
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_017769 (505455..507452) NCBI
  • BioCyc: MYY_RS02715 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    ATGAAATCAATCAACAAATTTTTAACAATGCTTGCTGCCTTATTATTGACAGCGAGTAGC
    CTGTTTTCAGCTGCAACAGTTTTTGCGGCTGGGACGACAACAACATCTGTTACCGTTCAT
    AAACTATTGGCAACAGATGGGGATATGGATAAAATTGCAAATGAGTTAGAAACAGGTAAC
    TATGCTGGTAATAAAGTGGGTGTTCTACCTGCAAATGCAAAAGAAATTGCCGGTGTTATG
    TTCGTTTGGACAAATACTAATAATGAAATTATTGATGAAAATGGCCAAACTCTAGGAGTG
    AATATTGATCCACAAACATTTAAACTCTCAGGGGCAATGCCGGCAACTGCAATGAAAAAA
    TTAACAGAAGCTGAAGGAGCTAAATTTAACACGGCAAATTTACCAGCTGCTAAGTATAAA
    ATTTATGAAATTCACAGTTTATCAACTTATGTCGGTGAAGATGGAGCAACCTTAACAGGT
    TCTAAAGCAGTTCCAATTGAAATTGAATTACCATTGAACGATGTTGTGGATGCGCATGTG
    TATCCAAAAAATACAGAAGCAAAGCCAAAAATTGATAAAGATTTCAAAGGTAAAGCAAAT
    CCAGATACACCACGTGTAGATAAAGATACACCTGTGAACCACCAAGTTGGAGATGTTGTA
    GAGTACGAAATTGTTACAAAAATTCCAGCACTTGCTAATTATGCAACAGCAAACTGGAGC
    GATAGAATGACTGAAGGTTTGGCATTCAACAAAGGTACAGTGAAAGTAACTGTTGATGAT
    GTTGCACTTGAAGCAGGTGATTATGCTCTAACAGAAGTAGCAACTGGTTTTGATTTGAAA
    TTAACAGATGCTGGTTTAGCTAAAGTGAATGACCAAAACGCTGAAAAAACTGTGAAAATC
    ACTTATTCGGCAACATTGAATGACAAAGCAATTGTAGAAGTACCAGAATCTAATGATGTA
    ACATTTAACTATGGTAATAATCCAGATCACGGGAATACTCCAAAGCCGAATAAGCCAAAT
    GAAAACGGCGATTTGACATTGACCAAGACATGGGTTGATGCTACAGGTGCACCAATTCCG
    GCTGGAGCTGAAGCAACGTTCGATTTGGTTAATGCTCAGACTGGTAAAGTTGTACAAACT
    GTAACTTTGACAACAGACAAAAATACAGTTACTGTTAACGGATTGGATAAAAATACAGAA
    TATAAATTCGTTGAACGTAGTATAAAAGGGTATTCAGCAGATTATCAAGAAATCACTACA
    GCTGGAGAAATTGCTGTCAAGAACTGGAAAGACGAAAATCCAAAACCACTTGATCCAACA
    GAGCCAAAAGTTGTTACATATGGTAAAAAGTTTGTCAAAGTTAATGATAAAGATAATCGT
    TTAGCTGGGGCAGAATTTGTAATTGCAAATGCTGATAATGCTGGTCAATATTTAGCACGT
    AAAGCAGATAAAGTGAGTCAAGAAGAGAAGCAGTTGGTTGTTACAACAAAGGATGCTTTA
    GATAGAGCAGTTGCTGCTTATAACGCTCTTACTGCACAACAACAAACTCAGCAAGAAAAA
    GAGAAAGTTGACAAAGCTCAAGCTGCTTATAATGCTGCTGTGATTGCTGCCAACAATGCA
    TTTGAATGGGTGGCAGATAAGGACAATGAAAATGTTGTGAAATTAGTTTCTGATGCACAA
    GGTCGCTTTGAAATTACAGGCCTTCTTGCAGGTACATATTACTTAGAAGAAACAAAACAG
    CCTGCTGGTTATGCATTACTAACTAGCCGTCAGAAATTTGAAGTCACTGCAACTTCTTAT
    TCAGCGACTGGACAAGGCATTGAGTATACTGCTGGTTCAGGTAAAGATGACGCTACAAAA
    GTAGTCAACAAAAAAATCACGATCCCACAAACGGGTGGTATTGGTACAATTATCTTTGCT
    GTAGCAGGGGCTGTGATTATGGGTATTGCAGTGTACGCATATGTTAAAAACAACAAAGAT
    GAGGATCAACTTGCTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    1998

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: MYY_RS02715 [old locus tag: MYY_0533 ]
  • symbol: RrgB
  • description: PI-1 pilus major pilin RrgB
  • length: 665
  • theoretical pI: 4.75662
  • theoretical MW: 71391.6
  • GRAVY: -0.343008

⊟Function[edit | edit source]

  • TIGRFAM:
    fimbrial isopeptide formation D2 domain (TIGR04226; HMM-score: 76)
    and 1 more
    Cell structure Cell envelope Other LPXTG cell wall anchor domain (TIGR01167; HMM-score: 24.2)
  • TheSEED: see MYY_0533
  • PFAM:
    Transthyretin (CL0287) GramPos_pilinD3; Gram-positive pilin backbone subunit 3, Cna-B-like domain (PF16570; HMM-score: 96.5)
    Adhesin (CL0204) GramPos_pilinBB; Gram-positive pilin backbone subunit 2, Cna-B-like domain (PF16569; HMM-score: 83.7)
    Transthyretin (CL0287) SpaA; Prealbumin-like fold domain (PF17802; HMM-score: 82)
    and 8 more
    no clan defined Gram_pos_anchor; LPXTG cell wall anchor motif (PF00746; HMM-score: 30.2)
    Transthyretin (CL0287) CarboxypepD_reg; Carboxypeptidase regulatory-like domain (PF13620; HMM-score: 19.8)
    Cna_B; Cna protein B-type domain (PF05738; HMM-score: 18.9)
    E-set (CL0159) fn3; Fibronectin type III domain (PF00041; HMM-score: 17.6)
    no clan defined DUF1850; Domain of unknown function (DUF1850) (PF08905; HMM-score: 16.2)
    Transthyretin (CL0287) SdrD_B; SdrD B-like domain (PF17210; HMM-score: 15)
    no clan defined DUF5980; Family of unknown function (DUF5980) (PF19410; HMM-score: 13.4)
    TBCA; Tubulin binding cofactor A (PF02970; HMM-score: 12)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 2
  • DeepLocPro: Cell wall & surface
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0.1405
    • Cell wall & surface Score: 0.8315
    • Extracellular Score: 0.028
  • SignalP: Signal peptide SP(Sec/SPI) length 29 aa
    • SP(Sec/SPI): 0.98521
    • TAT(Tat/SPI): 0.007599
    • LIPO(Sec/SPII): 0.005712
    • Cleavage Site: CS pos: 29-30. VFA-AG. Pr: 0.9431
  • predicted transmembrane helices (TMHMM): 2

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000836218 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKSINKFLTMLAALLLTASSLFSAATVFAAGTTTTSVTVHKLLATDGDMDKIANELETGNYAGNKVGVLPANAKEIAGVMFVWTNTNNEIIDENGQTLGVNIDPQTFKLSGAMPATAMKKLTEAEGAKFNTANLPAAKYKIYEIHSLSTYVGEDGATLTGSKAVPIEIELPLNDVVDAHVYPKNTEAKPKIDKDFKGKANPDTPRVDKDTPVNHQVGDVVEYEIVTKIPALANYATANWSDRMTEGLAFNKGTVKVTVDDVALEAGDYALTEVATGFDLKLTDAGLAKVNDQNAEKTVKITYSATLNDKAIVEVPESNDVTFNYGNNPDHGNTPKPNKPNENGDLTLTKTWVDATGAPIPAGAEATFDLVNAQTGKVVQTVTLTTDKNTVTVNGLDKNTEYKFVERSIKGYSADYQEITTAGEIAVKNWKDENPKPLDPTEPKVVTYGKKFVKVNDKDNRLAGAEFVIANADNAGQYLARKADKVSQEEKQLVVTTKDALDRAVAAYNALTAQQQTQQEKEKVDKAQAAYNAAVIAANNAFEWVADKDNENVVKLVSDAQGRFEITGLLAGTYYLEETKQPAGYALLTSRQKFEVTATSYSATGQGIEYTAGSGKDDATKVVNKKITIPQTGGIGTIIFAVAGAVIMGIAVYAYVKNNKDEDQLA

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Julianna LeMieux, David L Hava, Alan Basset, Andrew Camilli
RrgA and RrgB are components of a multisubunit pilus encoded by the Streptococcus pneumoniae rlrA pathogenicity islet.
Infect Immun: 2006, 74(4);2453-6
[PubMed:16552078] [WorldCat.org] [DOI] (P p)Tanja D Becke, Stefan Ness, Benedikt K Kaufmann, Bastian Hartmann, Arndt F Schilling, Stefanie Sudhop, Markus Hilleringmann, Hauke Clausen-Schaumann
Pilus-1 Backbone Protein RrgB of Streptococcus pneumoniae Binds Collagen I in a Force-Dependent Way.
ACS Nano: 2019, 13(6);7155-7165
[PubMed:31184856] [WorldCat.org] [DOI] (I p)

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