PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 02-APR-2025

⊟Summary

• organism: Streptococcus pneumoniae ST556
• locus tag: MYY_RS04655 [old locus tag: MYY_0910 ]
• pan locus tag^?: PNEUPAN002654000
• symbol: MYY_RS04655
• pan gene symbol^?: ywbD
• synonym:
• product: class I SAM-dependent rRNA methyltransferase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: MYY_RS04655 [old locus tag: MYY_0910 ]
• symbol: MYY_RS04655
• product: class I SAM-dependent rRNA methyltransferase
• replicon: chromosome
• strand: +
• coordinates: 881359..882522
• length: 1164
• essential: unknown

⊟Accession numbers

• Location: NC_017769 (881359..882522) NCBI
• BioCyc: MYY_RS04655 BioCyc
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_1212 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  1021
  1081
  1141
  
  ATGAATAGAATAAGAGTCAGCAAAAGGGTTGAAAAGAAGCTTGCTAAGGGGCTAGTTTTA
  CTAGAAGCCAGTGATCTTGAGAATGTCAATCTTAAGGATCAGGAAGTAGAGGTGCAGGGT
  CAGGAAGGAAACTTTCTTGGGACTGCCTACCTTTCTCAGCAAAACAAGGGCTTGGGCTGG
  TTTGTCAGCAAAGACAAGGTGGCCTTCAATCAAGCTTTCTTTGAAACGTTGTTTAGAAAA
  GCCAAAGAAAAGAGAAGCGCCTACTATCAAGATGATTTAACAACTACCTATCGTCTCTTT
  AATCAAGAGGGAGATGGCTTTGGGGGTCTGACAGTGGACCTTTATGGCGACTACGCCGTC
  TTTTCTTGGTATAACTCTTATGTTTATCAGATTCGTCAGACTATATCAGAAGCCTTTAGA
  CAGGTTTTCCCTGAGGTTTTAGGGGCTTATGAGAAAATTCGCTTTAAGGGTTTGGACTAT
  GAATCTGCCCATGTTTATGGTCAAGAAGCACCTGACTTTTTCACTGTTTTAGAAAATGGT
  GTCCTGTATCAAGTCTTTATGAATGATGGCTTGATGACAGGAATTTTCCTAGACCAGCAT
  GAGGTTCGCGGTAGTTTAGTTGACGGCTTGGCTATGGGTAAATCCTTGCTCAATATGTTT
  TCCTACACAGCGGCTTTTTCAGTAGCTGCGGCCATGGGAGGAGCTAGCCAGACAACTTCT
  GTTGATCTAGCCAAACGTTCACGAGAATTGTCTCAAGCGCATTTTCAGGCAAATGGGCTC
  AGCACAGACGAGCATCGTTTTATAGTCATGGATGTCTTTGAGTATTTCAAATATGCCAAA
  CGCAAAAACTTGACCTACGATGTGATTGTCCTAGATCCGCCTAGCTTTGCTCGGAATAAA
  AAACAAACTTTCTCTGTGGCCAAGGATTATCACAAGTTGATTTCCCAGAGTCTTGAGATT
  TTAAATCCGGGAGGGATTATCATTGCCAGTACCAATGCTGCCAATGTTTCCCGTCAGAAA
  TTTACAGAACAAATTGATAAAGGCTTTGCAGGAAGAAGTTACCAGATTTTAAACAAATAT
  GGTCTTCCAGCAGATTTTGCCTATAATAAAAAAGATGAAAGTAGTAATTACCTCAAGGTG
  ATTAGTATGAAGGTTAGTAAATGA
  60
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  840
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  960
  1020
  1080
  1140
  1164
  

⊟Protein

⊟General

• locus tag: MYY_RS04655 [old locus tag: MYY_0910 ]
• symbol: MYY_RS04655
• description: class I SAM-dependent rRNA methyltransferase
• length: 387
• theoretical pI: 9.04
• theoretical MW: 43823.3
• GRAVY: -0.330491

⊟Function

• reaction:
  EC 2.1.1.-?  ExPASy
• TIGRFAM:
  Genetic information processing Protein synthesis tRNA and rRNA base modification 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD (TIGR00095; EC 2.1.1.171; HMM-score: 24.2)
  and 1 more
  Genetic information processing Protein fate Protein modification and repair protein-(glutamine-N5) methyltransferase, release factor-specific (TIGR03534; EC 2.1.1.-; HMM-score: 15.7)
• TheSEED: see MYY_0910
• PFAM:
  NADP_Rossmann (CL0063) Methyltrans_SAM; S-adenosylmethionine-dependent methyltransferase (PF10672; HMM-score: 102.8)
  and 4 more
  PUA (CL0178) PUA_3; PUA-like domain (PF17785; HMM-score: 39.6)
  NADP_Rossmann (CL0063) Cons_hypoth95; Conserved hypothetical protein 95 (PF03602; HMM-score: 30.3)
  MTS; Methyltransferase small domain (PF05175; HMM-score: 23.8)
  Methyltransf_25; Methyltransferase domain (PF13649; HMM-score: 16.2)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: unknown (no significant prediction)
  • Cytoplasmic Score: 2.5
  • Cytoplasmic Membrane Score: 2.5
  • Cellwall Score: 2.5
  • Extracellular Score: 2.5
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.9824
  • Cytoplasmic Membrane Score: 0.0026
  • Cell wall & surface Score: 0.0016
  • Extracellular Score: 0.0134
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.019022
  • TAT(Tat/SPI): 0.000362
  • LIPO(Sec/SPII): 0.002006
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_001822571 NCBI
• UniProt:

⊟Protein sequence

• MNRIRVSKRVEKKLAKGLVLLEASDLENVNLKDQEVEVQGQEGNFLGTAYLSQQNKGLGWFVSKDKVAFNQAFFETLFRKAKEKRSAYYQDDLTTTYRLFNQEGDGFGGLTVDLYGDYAVFSWYNSYVYQIRQTISEAFRQVFPEVLGAYEKIRFKGLDYESAHVYGQEAPDFFTVLENGVLYQVFMNDGLMTGIFLDQHEVRGSLVDGLAMGKSLLNMFSYTAAFSVAAAMGGASQTTSVDLAKRSRELSQAHFQANGLSTDEHRFIVMDVFEYFKYAKRKNLTYDVIVLDPPSFARNKKQTFSVAKDYHKLISQSLEILNPGGIIIASTNAANVSRQKFTEQIDKGFAGRSYQILNKYGLPADFAYNKKDESSNYLKVISMKVSK

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Transcription

• transcription start site:

⊟Expression data

• PneumoExpress for strain D39V: SPV_1212 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications