PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 08-SEP-2024

⊟Summary

• organism: Streptococcus pneumoniae BM6001
• locus tag: ODS73_RS07220 [old locus tag: ODS73_07220 ]
• pan locus tag^?: PNEUPAN002686000
• symbol: ODS73_RS07220
• pan gene symbol^?: —
• synonym:
• product: DUF948 domain-containing protein

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: ODS73_RS07220 [old locus tag: ODS73_07220 ]
• symbol: ODS73_RS07220
• product: DUF948 domain-containing protein
• replicon: chromosome
• strand: -
• coordinates: 1407401..1407784
• length: 384
• essential: unknown

⊟Accession numbers

• Location: NZ_CP107038 (1407401..1407784) NCBI
• BioCyc:
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_1242 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  
  ATGTTAGAAGTTGCATATATTCTTGTTGCCCTAGCTGTGATTGTCTTTTTGGTCTATCTG
  ATCATTACTGTACAAAAGCTTGGTCGTGTCATCGATGAAACAGAAAAGACGATTAAAACC
  TTGACTTCAGATGTGGATGTGACCTTGCATCACACCAATGAGTTGTTGGCTAAGGTCAAT
  GTCTTGGCAGATGATATCAATGTCAAGGTGGCTACGATTGATCCACTCTTCAGTGCTGTT
  GCAGATTTATCTCTATCTGTTTCAGACCTCAATGACCATGCGCGTGTCTTGAGCAAGAAA
  GCTTCATCAGCTGGTTCAAAAACACTCAAGACTGGTGCAAGTCTGTCAGCTCTTCGTCTT
  GCAAGTAAATTTTTCAAAAAATAA
  60
  120
  180
  240
  300
  360
  384
  

⊟Protein

⊟General

• locus tag: ODS73_RS07220 [old locus tag: ODS73_07220 ]
• symbol: ODS73_RS07220
• description: DUF948 domain-containing protein
• length: 127
• theoretical pI: 9.55892
• theoretical MW: 13693
• GRAVY: 0.492913

⊟Function

• TIGRFAM:
  heavy metal sensor kinase (TIGR01386; EC 2.7.13.3; HMM-score: 15.3)
  integral membrane protein (TIGR04561; HMM-score: 14.2)
  Cellular processes Cellular processes Cell division cell division protein FtsL (TIGR02209; HMM-score: 13.5)
• TheSEED: data available for D39, Hungary19A-6, TIGR4
• PFAM:
  no clan defined DUF948; Bacterial protein of unknown function (DUF948) (PF06103; HMM-score: 87.5)
  and 10 more
  BORCS7; BLOC-1-related complex sub-unit 7 (PF16088; HMM-score: 16.9)
  Laminin_II; Laminin Domain II (PF06009; HMM-score: 15.5)
  TPR (CL0020) DUF6377; Domain of unknown function (DUF6377) (PF19904; HMM-score: 14.6)
  no clan defined BLOC1_2; Biogenesis of lysosome-related organelles complex-1 subunit 2 (PF10046; HMM-score: 13.9)
  GPCR_A (CL0192) TAS2R; Taste receptor protein (TAS2R) (PF05296; HMM-score: 13.8)
  no clan defined Effector_1; Effector from type III secretion system (PF04518; HMM-score: 13)
  ATP_synthase (CL0255) ATP-synt_B; ATP synthase B/B' CF(0) (PF00430; HMM-score: 12.8)
  FtsL (CL0225) DivIC; Septum formation initiator (PF04977; HMM-score: 12.7)
  OML_zippers (CL0590) LPP; Lipoprotein leucine-zipper (PF04728; HMM-score: 11.7)
  no clan defined DUF2670; Protein of unknown function (DUF2670) (PF10875; HMM-score: 11.2)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: unknown (no significant prediction)
  • Cytoplasmic Score: 2.5
  • Cytoplasmic Membrane Score: 2.5
  • Cellwall Score: 2.5
  • Extracellular Score: 2.5
  • Internal Helix: 1
• DeepLocPro: Cytoplasmic Membrane
  • Cytoplasmic Score: 0
  • Cytoplasmic Membrane Score: 0.9971
  • Cell wall & surface Score: 0.0001
  • Extracellular Score: 0.0028
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.035507
  • TAT(Tat/SPI): 0.000335
  • LIPO(Sec/SPII): 0.004866
• predicted transmembrane helices (TMHMM): 1

⊟Accession numbers

• GI:
• RefSeq: WP_000895048 NCBI
• UniProt:

⊟Protein sequence

• MLEVAYILVALAVIVFLVYLIITVQKLGRVIDETEKTIKTLTSDVDVTLHHTNELLAKVNVLADDINVKVATIDPLFSAVADLSLSVSDLNDHARVLSKKASSAGSKTLKTGASLSALRLASKFFKK

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Expression data

• PneumoExpress for strain D39V: SPV_1242 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications