PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 15-DEC-2024

⊟Summary

• organism: Streptococcus pneumoniae 670-6B
• locus tag: SP670_RS14130 [old locus tag: SP670_0639 ]
• pan locus tag^?: PNEUPAN000276000
• symbol: SP670_RS14130
• pan gene symbol^?: uvrB_1
• synonym:
• product: DEAD/DEAH box helicase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SP670_RS14130 [old locus tag: SP670_0639 ]
• symbol: SP670_RS14130
• product: DEAD/DEAH box helicase
• replicon: chromosome
• strand: +
• coordinates: 590124..591320
• length: 1197
• essential: unknown

⊟Accession numbers

• Location: NC_014498 (590124..591320) NCBI
• BioCyc:
• MicrobesOnline:
• PneumoBrowse for strain D39V:

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  1021
  1081
  1141
  
  ATGATTCAATCTCTATTTAAGTTGGAAAATAGTCAAAGTCTTTTGGATGAGTATGAGATG
  ATGATTGTGGATGAGTGTCACCATATCTCTGCCTTGATGTTTGAAAAAGTTGTTGCTCAG
  CTTAGAGGGAAGTATCTTTACGGTTTGACGGCTACGCCTGAGCGTAAGAATGGTCATGAG
  CCTATTGTTTTTCAGAGAATTGGTGAGATACTCCATACTGCTGATAAGAGGGAAACGGAT
  TTTAAACGGCAATTGCAATTAAGATTCACTTCTTTTGGTCATTTGGAGATTGAAAAGACC
  AAAGCAAGTAATTTTATACAGCTCAGTGATTGGATTGCTACAGACTCAGCGAGGAATCAG
  TTGATTCTCAAGGATATTCTAGCCCAAGTGGCAGAAGGACGGAATATCTTGGGTTTAGTT
  AATCGAATTCAACAGATAGATGTCTTTGAAAAGTTATTGAAAGAGAAAGAGGTTGATGAC
  TGTTACATTATTAGCGGAAAAACCAAAGTCCGAGAAAGAACGAGTTTACTGGAGACGTTA
  GAACAGTTAGATAAAGGGTTTGTTTTGTTGTCTACTGGAAAATACATTGGCGAAGATTTT
  GACTTACCTCAGTTGGACACGCTTATCTTGGCAGCACCCTTTTCTTGGAAAAATAATTTA
  ATTCAGTATGCAGGTCGGATTCATAGAAACTACAAGGATAAGTCTTTGGTGCGTATTTTC
  GATTATGTGGATATTCATGTTCCTTATTTAGAAAAGATGTTTCAGAAACGACAAGTAGCT
  TATCGAAAGATGGATTATCGTGTCATCGAGGGTGAGGAGAAACAATTCGTTTATGTTGAT
  AGTAGATATGAGAAGGTGTTGAGAGAGGACTTAGCAGGGGAAAGACAGGAATGTCTGCTT
  ATTTTACCTTATGTGCACCAGACAAAACTGATGAATTTTCTAAAAGAATTTAGGATTAGT
  CAAATTGAGATATGTATACCAGAGACGGTTGCAAATAAAGCATGGCTAGACCAGTTGAAG
  AGCCAGAAAATTAAAGTGTCTTTTACTCAATCAAAAATAGTAACGCCTATTCTTTTGGTG
  AATAAGACTATTGTTTGGTATGGTGCAATGCCATTATTAGGGAAGGTAGATGAGATGACC
  ATATTACGTTTGGAATCAGCTAGTATAGTTTCTGAACTAGTGGCAGGTTTACGATAG
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  840
  900
  960
  1020
  1080
  1140
  1197
  

⊟Protein

⊟General

• locus tag: SP670_RS14130 [old locus tag: SP670_0639 ]
• symbol: SP670_RS14130
• description: DEAD/DEAH box helicase
• length: 398
• theoretical pI: 7.9725
• theoretical MW: 46358.6
• GRAVY: -0.20402

⊟Function

• reaction:
  EC 3.6.4.-?  ExPASy
• TIGRFAM:
  DNA phosphorothioation system restriction enzyme (TIGR04095; HMM-score: 38.8)
  and 1 more
  Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA repair helicase rad25 (TIGR00603; EC 3.6.4.12; HMM-score: 20.8)
• TheSEED: see SP670_0639
• PFAM:
  P-loop_NTPase (CL0023) ResIII; Type III restriction enzyme, res subunit (PF04851; HMM-score: 32.7)
  Helicase_C; Helicase conserved C-terminal domain (PF00271; HMM-score: 31.6)
  and 3 more
  iSTAND; inactive STAND (PF19995; HMM-score: 17.2)
  HTH (CL0123) SAC3_GANP; SAC3/GANP family (PF03399; HMM-score: 14.7)
  Ferritin (CL0044) AurF; P-aminobenzoate N-oxygenase AurF (PF11583; HMM-score: 11.7)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.9257
  • Cytoplasmic Membrane Score: 0.0664
  • Cell wall & surface Score: 0.0049
  • Extracellular Score: 0.003
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.001371
  • TAT(Tat/SPI): 0.000282
  • LIPO(Sec/SPII): 0.000214
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_000616193 NCBI
• UniProt:

⊟Protein sequence

• MIQSLFKLENSQSLLDEYEMMIVDECHHISALMFEKVVAQLRGKYLYGLTATPERKNGHEPIVFQRIGEILHTADKRETDFKRQLQLRFTSFGHLEIEKTKASNFIQLSDWIATDSARNQLILKDILAQVAEGRNILGLVNRIQQIDVFEKLLKEKEVDDCYIISGKTKVRERTSLLETLEQLDKGFVLLSTGKYIGEDFDLPQLDTLILAAPFSWKNNLIQYAGRIHRNYKDKSLVRIFDYVDIHVPYLEKMFQKRQVAYRKMDYRVIEGEEKQFVYVDSRYEKVLREDLAGERQECLLILPYVHQTKLMNFLKEFRISQIEICIPETVANKAWLDQLKSQKIKVSFTQSKIVTPILLVNKTIVWYGAMPLLGKVDEMTILRLESASIVSELVAGLR

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Transcription

• transcription start site:

⊟Expression data

• PneumoExpress for strain D39V:

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications