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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 11-FEB-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae ATCC 700669
  • locus tag: SPN23F_RS02660 [old locus tags: SPN23F05190 SPN23F_05190 ]
  • pan locus tag?: PNEUPAN000276000
  • symbol: SPN23F_RS02660
  • pan gene symbol?: uvrB_1
  • synonym:
  • product: TOTE conflict system archaeo-eukaryotic primase domain-containing protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN23F_RS02660 [old locus tags: SPN23F05190 SPN23F_05190 ]
  • symbol: SPN23F_RS02660
  • product: TOTE conflict system archaeo-eukaryotic primase domain-containing protein
  • replicon: chromosome
  • strand: +
  • coordinates: 496704..499262
  • length: 2559
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_011900 (496704..499262) NCBI
  • BioCyc: SPN23F_RS02660 BioCyc
  • MicrobesOnline: see SPN23F05190
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    ATGGAACGCTCTCAGTTCGAGGAGATGTTCCAACTTCAAAGTAGTCGCTTGACGACGCAA
    GAAAAATTACAATTGTTTACCTCTGTGTTTGCTGGCCGTTATGATGTTTATGCTAAGAAT
    TTTATCAATGAACAAGGGAAAATTCAGTATTTTCCTTCCTATGATTATGGTTGGAAGCAG
    TTGCCACCTGAAAAACGGAGTTTCCAGACATTGACGAACTCCGTTTTGAAATCTCATTTT
    CGTGGGGAGGCAGCTATCGGTATCTTTCCTATGCACTTAGATGATAGCTGTTATTTTTTG
    GTACTGGATTTGGATGAAGGAGATTGGAAAGAAGCTGGTTTAACCATTCGAAGAATAGCC
    AGGGAACGCCAGATGGAAGCCCATTTAGAGATTTCTCGTTCGGGTTACGGACTCCATATT
    TGGTTCTTCTTTGAGGAAGCGATTCTGAGTCGAAAGGCTCGCCTGTTTGGAAAGAAACTA
    TTAGAATTGGCTATGCAGGAAAGTATGCAACTGTCCTTTGATTCTTTTGATCGCATGTTT
    CCAAATCAGGATGTTCTTCCTAAAGGTGGATTTGATAATTTAATTTCCCTTCCTTTTCAA
    GGAGAAGCTTATCATCAAGGGCGAACGGTCTTTGTGGATGAACAGTTTCAGCCTTATGAA
    GATCAATGGAGGTATCTACAAGAAATTCAGAAGATTTCAACTGCTAAAGTGGCACTGTTA
    ATCCAAGAGGAGTTAGGCAAGCAAGAATTGGACAAGGAGTTGAAGATCGTCTTATCCAAT
    ATGATCCAACTTGAAAAATCGTCTGTGACACCCAAGACACTGTTTTTCTTGAAAAATATG
    GCTTCATTTTCTAATCCCGAATTTTATTTAAAGCAGGCTATGCGACAGCCAACCTATCAA
    ATTCCTGAGAGAATGTATTTATTTGGAGAATCCGATCATTATTTATGGTTGCCAAGAGGT
    TTGCTGTATCCATTGCAAGATAAATTTAAGCAGGTATCTGTGGAAGATAGGAGAAAGGTA
    CAAAGGTCTATTAGCGTGGAATTTAAGGGAGAACTCACTTTTGAGCAAGAGTTAGCCCTG
    TCAGATATGACTTCTAAAGAAAATGGTTTACTTCATGCGGAGACTGGTTTTGGGAAGACC
    GTTTTAGGTGCTGCTCTTATCTCTGAACGGAAAACAAAAACAATTATTCTAGTCCATAAT
    AAGCAACTCTTAGACCAATGGCTAGATCGCTTAAACTGCTTTTTGACTTTCGAAGAGGAG
    GAGGCTATCCGTTATACGGCATCAGGTCGTGAAAAGGTAATCGGCTATGTTGGACAGTAC
    GGTGGGACTAAGAAATGGCTGAGTAAACTGGTTGATGTCGTTATGATTCAATCTCTATTT
    AAGTTGGAAAATAGTCAAAGTCTTTTGGATGAGTATGAGATGATGATTGTGGATGAGTGT
    CATCATGTCTCTGCCTTGATGTTTGAAAAAGTTGTTGCTCAGTTTAGAGGGAAGTATCTT
    TACGGTTTGACGGCTACGCCTGAGCGTAAGAATGGTCATGAGCCTATTGTTTTTCAGAGA
    ATTGGTGAGATACTCCATACTGCTGATAAGAGGGAAACGGATTTTAAACGGCAATTGCAA
    TTAAGATTCACTTCTTTTGGTCATTTGGAGATTGAAAAGACCAAAGCAAGTAATTTTATA
    CAGCTCAGTGATTGGATTGCTACAGACTCAGCGAGGAATCAGTTGATTCTCAAGGATATT
    CTAGCCCAAGTGGCAGAAGGACGGAATATCTTGGTTTTAGTTAATCGAATTCAACAGATA
    GATGTCTTTGAAAAGTTATTGAAAGAGAAAGAGGTTGATGGCTGTTACATTATTAGCGGA
    AAAACCAAAGTCCGAGAAAGAACGAGTTTACTGGAGACGTTAGAACAGTTAGATAAAGGG
    TTTGTTTTGTTGTCTACTGGAAAATACATTGGCGAAGGTTTTGACTTACCTCAGTTGGAC
    ACGCTTATCTTGGCAGCACCCTTTTCTTGGAAAAATAATTTAATTCAGTATGCAGGTCGG
    ATTCATAGAAACTACAAGGATAAGTCTTTGGTGCGTATTTTCGATTATGTGGATATTCAT
    GTTCCTTATTTAGAAAAGATGTTTCAGAAACGACAAGTAGCTTATCGAAAGATGGATTAT
    CGTGTCATCGAGGGTGAGGAGAAACAATTCGTTTATGTTGATAGTAGATATGAGAAGGTG
    TTGAGAGAGGACTTAGCAGGGGAAAGACAGGAATGTCTGCTTATTTTACCTTATGTGCAC
    CAGACAAAACTGATGAATTTTCTAAAAGAATTTAGGATTAGTCAAATTGAGATATGTATA
    CCAGAGACGGTTGCAAATAAAGCATGGCTAGACCAGTTGAAGAGCCAGAAAATTAAAGTG
    TCTTTTACTCAATCAAAAATAGTAACGCCTATTCTTTTGGTGAATAAGACTATTGTTTGG
    TATGGTGCAATGCCATTATTAGGGAAGGTAGATGAGATGACCATATTACGTTTGGAATCA
    GCTAGTATAGTTTCTGAACTAGTGGCAGGTTTACGATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2520
    2559

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN23F_RS02660 [old locus tags: SPN23F05190 SPN23F_05190 ]
  • symbol: SPN23F_RS02660
  • description: TOTE conflict system archaeo-eukaryotic primase domain-containing protein
  • length: 852
  • theoretical pI: 7.44962
  • theoretical MW: 99370
  • GRAVY: -0.30493

⊟Function[edit | edit source]

  • TIGRFAM:
    DNA phosphorothioation system restriction enzyme (TIGR04095; HMM-score: 55.2)
    and 3 more
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA repair helicase rad25 (TIGR00603; EC 3.6.4.12; HMM-score: 37.5)
    CRISPR-associated helicase Cas3 (TIGR01587; HMM-score: 24.1)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair excinuclease ABC subunit B (TIGR00631; EC 3.1.25.-; HMM-score: 22.9)
  • TheSEED: see SPN23F05190
  • PFAM:
    P-loop_NTPase (CL0023) ResIII; Type III restriction enzyme, res subunit (PF04851; HMM-score: 76.8)
    and 7 more
    Helicase_C; Helicase conserved C-terminal domain (PF00271; HMM-score: 43)
    DEAD; DEAD/DEAH box helicase (PF00270; HMM-score: 31.3)
    SNF2-rel_dom; SNF2-related domain (PF00176; HMM-score: 29.7)
    iSTAND; inactive STAND (PF19995; HMM-score: 16.9)
    AAA_22; AAA domain (PF13401; HMM-score: 14.8)
    Helicase_C_2; Helicase C-terminal domain (PF13307; HMM-score: 13.3)
    Ferritin (CL0044) AurF; P-aminobenzoate N-oxygenase AurF (PF11583; HMM-score: 11.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9046
    • Cytoplasmic Membrane Score: 0.0774
    • Cell wall & surface Score: 0.0126
    • Extracellular Score: 0.0054
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.024235
    • TAT(Tat/SPI): 0.017547
    • LIPO(Sec/SPII): 0.002469
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000442363 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MERSQFEEMFQLQSSRLTTQEKLQLFTSVFAGRYDVYAKNFINEQGKIQYFPSYDYGWKQLPPEKRSFQTLTNSVLKSHFRGEAAIGIFPMHLDDSCYFLVLDLDEGDWKEAGLTIRRIARERQMEAHLEISRSGYGLHIWFFFEEAILSRKARLFGKKLLELAMQESMQLSFDSFDRMFPNQDVLPKGGFDNLISLPFQGEAYHQGRTVFVDEQFQPYEDQWRYLQEIQKISTAKVALLIQEELGKQELDKELKIVLSNMIQLEKSSVTPKTLFFLKNMASFSNPEFYLKQAMRQPTYQIPERMYLFGESDHYLWLPRGLLYPLQDKFKQVSVEDRRKVQRSISVEFKGELTFEQELALSDMTSKENGLLHAETGFGKTVLGAALISERKTKTIILVHNKQLLDQWLDRLNCFLTFEEEEAIRYTASGREKVIGYVGQYGGTKKWLSKLVDVVMIQSLFKLENSQSLLDEYEMMIVDECHHVSALMFEKVVAQFRGKYLYGLTATPERKNGHEPIVFQRIGEILHTADKRETDFKRQLQLRFTSFGHLEIEKTKASNFIQLSDWIATDSARNQLILKDILAQVAEGRNILVLVNRIQQIDVFEKLLKEKEVDGCYIISGKTKVRERTSLLETLEQLDKGFVLLSTGKYIGEGFDLPQLDTLILAAPFSWKNNLIQYAGRIHRNYKDKSLVRIFDYVDIHVPYLEKMFQKRQVAYRKMDYRVIEGEEKQFVYVDSRYEKVLREDLAGERQECLLILPYVHQTKLMNFLKEFRISQIEICIPETVANKAWLDQLKSQKIKVSFTQSKIVTPILLVNKTIVWYGAMPLLGKVDEMTILRLESASIVSELVAGLR

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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