PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 15-DEC-2024

⊟Summary

• organism: Streptococcus pneumoniae 70585
• locus tag: SP70585_RS01960 [old locus tag: SP70585_0398 ]
• pan locus tag^?: PNEUPAN001090000
• symbol: ftsL
• pan gene symbol^?: ftsL
• synonym:
• product: cell division protein FtsL

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SP70585_RS01960 [old locus tag: SP70585_0398 ]
• symbol: ftsL
• product: cell division protein FtsL
• replicon: chromosome
• strand: +
• coordinates: 350689..351006
• length: 318
• essential: unknown other strains

⊟Accession numbers

• Location: NC_012468 (350689..351006) NCBI
• BioCyc: SP70585_RS01960 BioCyc
• MicrobesOnline: see SP70585_0398
• PneumoBrowse for strain D39V: SPV_0305 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  
  ATGGCAGAAAAAATGGAAAAAACAGGTCAAATACTACAGATGCAACTTAAACGGTTTTCG
  CGTGTGGAAAAAGCTTTTTACTTTTCCATTGCTGTAACCACTCTTATTGTAGCCATTAGT
  ATTATTTTTATGCAGACCAAGCTCTTGCAAGTGCAGAATGATTTGACAAAAATCAATGCG
  CAGATAGAGGAAAAGAAAACCGAATTGGACGATGCCAAGCAAGAGGTCAATGAACTATTA
  CGTGCAGAACGTTTGAAAGAAATTGCCAATTCACACGATTTGCAATTAAACAATGAAAAT
  ATTAGAATAGCGGAGTAA
  60
  120
  180
  240
  300
  318
  

⊟Protein

⊟General

• locus tag: SP70585_RS01960 [old locus tag: SP70585_0398 ]
• symbol: FtsL
• description: cell division protein FtsL
• length: 105
• theoretical pI: 5.93238
• theoretical MW: 12206.1
• GRAVY: -0.330476

⊟Function

• TIGRFAM:
  Cellular processes Cellular processes Cell division cell division protein FtsL (TIGR02209; HMM-score: 76.5)
  and 1 more
  Metabolism Transport and binding proteins Cations and iron carrying compounds transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family (TIGR00802; HMM-score: 12.8)
• TheSEED: see SP70585_0398
• PFAM:
  FtsL (CL0225) DivIC; Septum formation initiator (PF04977; HMM-score: 22.5)
  and 10 more
  TPR (CL0020) DUF6377; Domain of unknown function (DUF6377) (PF19904; HMM-score: 16.6)
  no clan defined SIMPL; Protein of unknown function (DUF541) (PF04402; HMM-score: 15.7)
  DUF948; Bacterial protein of unknown function (DUF948) (PF06103; HMM-score: 15.3)
  Vps51 (CL0295) COG2; COG (conserved oligomeric Golgi) complex component, COG2 (PF06148; HMM-score: 15.3)
  no clan defined TolA_bind_tri; TolA binding protein trimerisation (PF16331; HMM-score: 15.2)
  DUF3566; Transmembrane domain of unknown function (DUF3566) (PF12089; HMM-score: 14)
  DUF4014; Protein of unknown function (DUF4014) (PF13198; HMM-score: 12.6)
  Cache (CL0165) sCache_2; Single Cache domain 2 (PF17200; HMM-score: 12.2)
  no clan defined Nairo_nucleo; Nucleocapsid N protein (PF02477; HMM-score: 11.9)
  Spc24; Spc24 subunit of Ndc80 (PF08286; HMM-score: 8.6)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helix: 1
• DeepLocPro: Cytoplasmic Membrane
  • Cytoplasmic Score: 0.0001
  • Cytoplasmic Membrane Score: 0.9746
  • Cell wall & surface Score: 0.0023
  • Extracellular Score: 0.0231
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.006205
  • TAT(Tat/SPI): 0.000253
  • LIPO(Sec/SPII): 0.00059
• predicted transmembrane helices (TMHMM): 1

⊟Accession numbers

• GI:
• RefSeq: WP_000818547 NCBI
• UniProt: see SP70585_0398

⊟Protein sequence

• MAEKMEKTGQILQMQLKRFSRVEKAFYFSIAVTTLIVAISIIFMQTKLLQVQNDLTKINAQIEEKKTELDDAKQEVNELLRAERLKEIANSHDLQLNNENIRIAE

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

• MicrobesOnline: rsmH > ftsL > pbp2X > mraY

⊟Regulation

• regulator:

⊟Transcription

• transcription start site:

⊟Expression data

• PneumoExpress for strain D39V: SPV_0305 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications