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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 15-DEC-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 70585
  • locus tag: SP70585_RS06335 [old locus tag: SP70585_1272 ]
  • pan locus tag?: PNEUPAN002465000
  • symbol: vicK
  • pan gene symbol?: vicK
  • synonym:
  • product: cell wall metabolism sensor histidine kinase VicK

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP70585_RS06335 [old locus tag: SP70585_1272 ]
  • symbol: vicK
  • product: cell wall metabolism sensor histidine kinase VicK
  • replicon: chromosome
  • strand: -
  • coordinates: 1180817..1182166
  • length: 1350
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    ATGCTTGATTTACTGAAACAAACCATTTTTACCAGAGATTTTATCTTTATCCTGATTTTG
    TTAGGTTTCATCCTTGTTGTGACCCTCTTATTACTGGAAAATAGACGTGATAATATTCAG
    TTGAAGCAAATCAATCAAAAGGTTAAAGATTTGATTGCAGGAGATTATTCCAAGGTTCTT
    GATATGCAAGGTGGGTCTGAAATCACCAATATTACCAATAATTTGAATGACTTGTCGGAG
    GTTATTCGTCTCACTCAGGAAAATCTAGAACAAGAGAGTAAGAGGCTAAATAGTATTCTG
    TTTTATATGACAGATGGGGTTCTTGCGACCAACCGTCGGGGTCAGATTATCATGATTAAC
    GATACAGCCAAGAAGCAACTGGGGTTGGTTAAGGAAGATGTTCTGAATAGAAGCATTTTG
    GAATTGCTCAAGATAGAAGAAAACTATGAATTGCGTGATTTGATTACCCAAAGTCCAGAA
    TTGTTGCTAGATTCCCAAGATATCAATGGCGAATATTTGAACCTTCGAGTTCGCTTTGCC
    TTGATACGTCGAGAGTCTGGCTTTATTTCAGGTTTGGTGGCTGTTTTGCATGATACGACG
    GAGCAGGAGAAGGAAGAACGCGAACGAAGACTCTTTGTTTCCAATGTTAGCCATGAGTTA
    CGGACTCCTCTGACTAGCGTAAAATCCTATCTTGAAGCCTTGGATGAGGGGGCTTTGTGT
    GAAACTGTAGCACCAGACTTTATCAAGGTTTCTCTTGATGAGACCAACCGTATGATGCGC
    ATGGTGACGGATCTCCTCCATCTTTCACGTATTGATAATGCTACCAGTCACCTAGATGTG
    GAACTGATTAACTTCACTGCTTTTATTACCTTTATCCTCAATCGTTTTGACAAGATGAAA
    GGACAGGAAAAGGAGAAAAAATATGAGTTGGTGAGAGATTATCCCATCAATTCTATCTGG
    ATGGAAATTGATACAGATAAGATGACGCAGGTTGTCGACAATATTTTAAATAATGCTATT
    AAGTATTCGCCAGATGGGGGTAAAATCACTGTCAGAATGAAGACAACTGAAGACCAGATG
    ATTTTATCCATTTCTGACCACGGTTTGGGGATTCCTAAGCAGGATTTACCACGTATCTTT
    GACCGTTTCTATCGTGTGGATCGTGCTAGAAGTCGTGCACAAGGTGGTACAGGTCTAGGA
    CTGTCTATCGCTAAAGAAATTATCAAACAACATAAGGGCTTTATTTGGGCCAAGAGTGAA
    TACGGCAAGGGTTCAACCTTTACCATTGTGCTCCCTTATGATAAGGATGCAGTGAAAGAA
    GAAGTATGGGAGGATGAAGTAGAAGACTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1350

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP70585_RS06335 [old locus tag: SP70585_1272 ]
  • symbol: VicK
  • description: cell wall metabolism sensor histidine kinase VicK
  • length: 449
  • theoretical pI: 4.97071
  • theoretical MW: 51712.1
  • GRAVY: -0.276837

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.13.3?  ExPASy
    Histidine kinase ATP + protein L-histidine = ADP + protein N-phospho-L-histidine
  • TIGRFAM:
    Signal transduction Signal transduction Two-component systems phosphate regulon sensor kinase PhoR (TIGR02966; EC 2.7.3.-; HMM-score: 265.8)
    and 11 more
    heavy metal sensor kinase (TIGR01386; EC 2.7.13.3; HMM-score: 162.1)
    Signal transduction Signal transduction Two-component systems TMAO reductase sytem sensor TorS (TIGR02956; EC 2.7.13.3; HMM-score: 133.7)
    proteobacterial dedicated sortase system histidine kinase (TIGR03785; HMM-score: 96.6)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking putative PEP-CTERM system histidine kinase (TIGR02916; EC 2.7.13.3; HMM-score: 51.1)
    Signal transduction Signal transduction Two-component systems putative PEP-CTERM system histidine kinase (TIGR02916; EC 2.7.13.3; HMM-score: 51.1)
    Signal transduction Regulatory functions Small molecule interactions PAS domain S-box protein (TIGR00229; HMM-score: 40.7)
    Metabolism Central intermediary metabolism Nitrogen fixation nitrogen fixation negative regulator NifL (TIGR02938; HMM-score: 36.4)
    Signal transduction Regulatory functions Protein interactions nitrogen fixation negative regulator NifL (TIGR02938; HMM-score: 36.4)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA topoisomerase VI, B subunit (TIGR01052; EC 5.99.1.3; HMM-score: 17.7)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA mismatch repair protein MutL (TIGR00585; HMM-score: 14.2)
    Cellular processes Cellular processes Chemotaxis and motility flagellar protein FliS (TIGR00208; HMM-score: 8.4)
  • TheSEED: see SP70585_1272
  • PFAM:
    His_Kinase_A (CL0025) HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF02518; HMM-score: 106.5)
    and 13 more
    HisKA; His Kinase A (phospho-acceptor) domain (PF00512; HMM-score: 57.3)
    PAS_Fold (CL0183) PAS; PAS fold (PF00989; HMM-score: 38.7)
    PAS_9; PAS domain (PF13426; HMM-score: 36.4)
    His_Kinase_A (CL0025) HATPase_c_5; GHKL domain (PF14501; HMM-score: 22.5)
    HATPase_c_2; Histidine kinase-like ATPase domain (PF13581; HMM-score: 17.2)
    RRM (CL0221) RRM_Rrp7; Rrp7 RRM-like N-terminal domain (PF17799; HMM-score: 16.4)
    no clan defined Baculo_p24; Baculovirus P24 capsid protein (PF05073; HMM-score: 16)
    PAS_Fold (CL0183) PAS_8; PAS domain (PF13188; HMM-score: 15.9)
    no clan defined Cluap1; Clusterin-associated protein-1 (PF10234; HMM-score: 14.6)
    His_Kinase_A (CL0025) HATPase_c_3; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF13589; HMM-score: 14.6)
    no clan defined DUF3333; Domain of unknown function (DUF3333) (PF11812; HMM-score: 13.5)
    OB (CL0021) RMI1_C; Recq-mediated genome instability protein 1, C-terminal OB-fold (PF16099; HMM-score: 12.5)
    no clan defined LapA_dom; Lipopolysaccharide assembly protein A domain (PF06305; HMM-score: 12.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 1.05
    • Cytoplasmic Membrane Score: 8.78
    • Cellwall Score: 0.08
    • Extracellular Score: 0.09
    • Internal Helix: 1
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0.9969
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0031
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.012506
    • TAT(Tat/SPI): 0.001793
    • LIPO(Sec/SPII): 0.004292
  • predicted transmembrane helices (TMHMM): 1

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MLDLLKQTIFTRDFIFILILLGFILVVTLLLLENRRDNIQLKQINQKVKDLIAGDYSKVLDMQGGSEITNITNNLNDLSEVIRLTQENLEQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYELRDLITQSPELLLDSQDINGEYLNLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALCETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTAFITFILNRFDKMKGQEKEKKYELVRDYPINSIWMEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAVKEEVWEDEVED

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

J R Echenique, M C Trombe
Competence repression under oxygen limitation through the two-component MicAB signal-transducing system in Streptococcus pneumoniae and involvement of the PAS domain of MicB.
J Bacteriol: 2001, 183(15);4599-608
[PubMed:11443095] [WorldCat.org] [DOI] (P p)Aras Kadioglu, Josè Echenique, Sonia Manco, Marie-Claude Trombe, Peter W Andrew
The MicAB two-component signaling system is involved in virulence of Streptococcus pneumoniae.
Infect Immun: 2003, 71(11);6676-9
[PubMed:14573696] [WorldCat.org] [DOI] (P p)Wai-Leung Ng, Gregory T Robertson, Krystyna M Kazmierczak, Jingyong Zhao, Raymond Gilmour, Malcolm E Winkler
Constitutive expression of PcsB suppresses the requirement for the essential VicR (YycF) response regulator in Streptococcus pneumoniae R6.
Mol Microbiol: 2003, 50(5);1647-63
[PubMed:14651645] [WorldCat.org] [DOI] (P p)M Luz Mohedano, Karin Overweg, Alicia de la Fuente, Mark Reuter, Silvia Altabe, Francis Mulholland, Diego de Mendoza, Paloma López, Jerry M Wells
Evidence that the essential response regulator YycF in Streptococcus pneumoniae modulates expression of fatty acid biosynthesis genes and alters membrane composition.
J Bacteriol: 2005, 187(7);2357-67
[PubMed:15774879] [WorldCat.org] [DOI] (P p)Wai-Leung Ng, Ho-Ching Tiffany Tsui, Malcolm E Winkler
Regulation of the pspA virulence factor and essential pcsB murein biosynthetic genes by the phosphorylated VicR (YycF) response regulator in Streptococcus pneumoniae.
J Bacteriol: 2005, 187(21);7444-59
[PubMed:16237028] [WorldCat.org] [DOI] (P p)Skye M Barendt, Lok-To Sham, Malcolm E Winkler
Characterization of mutants deficient in the L,D-carboxypeptidase (DacB) and WalRK (VicRK) regulon, involved in peptidoglycan maturation of Streptococcus pneumoniae serotype 2 strain D39.
J Bacteriol: 2011, 193(9);2290-300
[PubMed:21378199] [WorldCat.org] [DOI] (I p)Maria L Mohedano, Mónica Amblar, Alicia de la Fuente, Jerry M Wells, Paloma López
The Response Regulator YycF Inhibits Expression of the Fatty Acid Biosynthesis Repressor FabT in Streptococcus pneumoniae.
Front Microbiol: 2016, 7;1326
[PubMed:27610104] [WorldCat.org] [DOI] (P e)

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