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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 17-JAN-2018

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae AP200
  • locus tag: SPAP_2052 [new locus tag: SPAP_RS10165 ]
  • pan locus tag?: PNEUPAN003633000
  • symbol: SPAP_2052
  • pan gene symbol?: adhE
  • synonym:
  • product: NAD-dependent aldehyde dehydrogenase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPAP_2052 [new locus tag: SPAP_RS10165 ]
  • symbol: SPAP_2052
  • product: NAD-dependent aldehyde dehydrogenase
  • replicon: chromosome
  • strand: -
  • coordinates: 1907738..1910410
  • length: 2673
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    TTGAAAGCTATGGAGGAAAATATGGCTGATAAAAAAACTGTGACACCAGAGGAAAAGAAA
    CTCGTTGCTGAAAAACACGTAGATGAGTTGGTTCAAAAAGCTCTAGTTGCCCTTGAAGAA
    ATGCGTAAATTGGATCAAGAACAAGTTGACTACATCGTTGCCAAAGCATCAGTAGCAGCT
    TTGGATGCCCACGGAGAATTGGCTTTACATGCCTTTGAAGAAACAGGACGTGGTGTATTT
    GAAGACAAAGCAACTAAGAACTTGTTTGCCTGTGAACACGTAGTAAACAACATGCGCCAC
    ACTAAGACAGTTGGCGTTATCGAAGAAGACGATGTAACAGGATTGACTCTTATTGCTGAA
    CCAGTTGGTGTTGTTTGTGGTATTACTCCAACAACAAACCCAACATCAACAGCAATCTTC
    AAATCATTGATTTCATTGAAGACACGTAACCCAATCGTCTTTGCCTTCCATCCATCAGCA
    CAAGAATCATCTGCTCATGCAGCTCGTATCGTCCGCGATGCAGCTATCGCAGCTGGTGCT
    CCTGAAAACTGTGTGCAATGGATTACTCAACCATCTATGGAAGCAACAAGTGCCCTTATG
    AACCACGAAGGTGTTGCGACAATCCTTGCAACAGGTGGTAATGCCATGGTTAAGGCGGCT
    TATTCATGTGGTAAACCAGCTCTTGGGGTAGGTGCCGGAAACGTTCCAGCTTATGTTGAA
    AAATCAGCAAACATTCGTCAAGCAGCACACGATATCGTCATGTCTAAATCATTTGATAAC
    GGTATGGTCTGTGCATCTGAACAAGCAGTTATCATTGATAAAGAAATTTACGATGAATTT
    GTAGCAGAGTTCAAATCTTACCACACTTACTTTGTAAGCAAAAAAGAAAAAGCTCTTCTT
    GAAGAGTTCTGCTTCGGCGTCAAAGCAAACAGCAAAAACTGTGCTGGTGCAAAATTGAAC
    GCTGACATCGTTGGTAAACCAGCAACTTGGATTGCAGAACAAGCAGGATTTACAGTTCCA
    GAAGGAACAAACATTCTTGCTGCAGAATGTAAAGAAGTTGGCGAAAATGAGCCATTGACT
    CGTGAAAAATTGTCACCAGTTATTGCAGTTTTGAAATCTGAAAGCCGTGAAGATGGTATT
    ACTAAGGCTCGTCAAATGGTTGAATTTAACGGTCTTGGACACTCAGCAGCTATCCACACA
    GCTGACGAAGAATTGACTAAAGAATTTGGTAAAGCTGTTAAAGCTATTCGTGTTATCTGT
    AACTCACCTTCTACTTTTGGTGGTATCGGGGACGTTTACAATGCCTTCTTGCCATCATTG
    ACACTTGGATGTGGTTCTTACGGACGCAACTCAGTTGGGGATAACGTTAGTGCCATTAAC
    CTCTTGAATATCAAAAAAGTCGGAAGACGGAGAAATAACATGCAATGGATGAAACTTCCT
    TCAAAAACATACTTTGAACGTGATTCAATTCAATACCTTCAAAAATGTCGTGACGTTGAA
    CGTGTCATGATCGTTACTGACCATGCCATGGTAGAGCTTGGTTTCCTTGATCGTATCATC
    GAACAACTGGACCTTCGTCGCAATAAGGTTGTTTACCAAATCTTTGCGGATGTAGAACCG
    GATCCAGATATCACAACTGTAAACCGTGGTACTGAGATTATGCGTGCCTTCAAACCAGAT
    ACCATCATCGCACTCGGTGGTGGGTCTCCAATGGATGCTGCCAAAGTAATGTGGCTCTTC
    TACGAGCAACCAGAAGTGGACTTCCGTGACCTTGTCCAAAAATTCATGGATATCCGTAAA
    CGTGCCTTCAAGTTCCCATTGCTTGGTAAGAAGACTAAATTCATCGCGATTCCAACTACA
    TCTGGTACAGGATCTGAAGTAACACCATTTGCCGTTATCTCTGATAAAGCAAACAACCGT
    AAATACCCAATCGCTGACTACTCATTGACACCAACTGTGGCAATCGTAGATCCTGCTTTG
    GTATTGACAGTTCCAGGATTTGTTGCTGCTGATACTGGTATGGACGTATTGACTCACGCG
    ACAGAAGCATACGTATCACAAATGGCTAGTGACTACACTGATGGTTTAGCACTTCAAGCC
    ATTAAATTGGTCTTTGAAAATCTCGAAAGCTCAGTTAAGAATGCAGACTTCCACTCACGT
    GAGAAAATGCATAACGCTTCAACAATCGCTGGTATGGCCTTTGCCAATGCCTTCCTAGGT
    ATTTCTCACTCAATGGCCCATAAGATTGGTGCGCAATTCCACACAATCCACGGTCGTACA
    AATGCTATCTTGCTTCCATACGTTATCCGTTACAACGGTACACGTCCAGCTAAGACAGCA
    ACATGGCCTAAGTACAACTACTACCGTGCAGATGAAAAATACCAAGATATCGCACGCATG
    CTTGGACTTCCAGCTTCTACTCCAGAAGAAGGGGTTGAATCTTACGCAAAAGCTGTCTAC
    GAACTCGGTGAACGTATTGGGATCCAAATGAATTTTAGAGACCAAGGAATTGACGAAAAA
    GAATGGAAAGAACATTCTCGTGAATTAGCCTTCCTGGCTTATGAAGACCAATGTTCACCA
    GCTAACCCACGTCTTCCAATGGTAGACCATATGCAAGAAATCATCGAAGATGCATACTAT
    GGCTACAAAGAAAGACCAGGACGCCGTAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2520
    2580
    2640
    2673

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPAP_2052 [new locus tag: SPAP_RS10165 ]
  • symbol: SPAP_2052
  • description: NAD-dependent aldehyde dehydrogenase
  • length: 890
  • theoretical pI: 6.37418
  • theoretical MW: 98093.5
  • GRAVY: -0.218539

⊟Function[edit | edit source]

  • TIGRFAM:
    acetaldehyde dehydrogenase (acetylating) (TIGR02518; EC 1.2.1.10; HMM-score: 463.2)
    and 15 more
    Metabolism Energy metabolism Sugars lactaldehyde reductase (TIGR02638; EC 1.1.1.77; HMM-score: 284.7)
    phosphonate metabolism-associated iron-containing alcohol dehydrogenase (TIGR03405; HMM-score: 178.1)
    NDMA-dependent methanol dehydrogenase (TIGR04266; EC 1.1.99.37; HMM-score: 119.7)
    Metabolism Amino acid biosynthesis Glutamate family glutamate-5-semialdehyde dehydrogenase (TIGR00407; EC 1.2.1.41; HMM-score: 58.1)
    Cellular processes Cellular processes Adaptations to atypical conditions betaine-aldehyde dehydrogenase (TIGR01804; EC 1.2.1.8; HMM-score: 53)
    5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase (TIGR02299; EC 1.2.1.60; HMM-score: 41.5)
    Metabolism Central intermediary metabolism Other succinate-semialdehyde dehydrogenase (TIGR01780; EC 1.2.1.-; HMM-score: 39.2)
    Metabolism Energy metabolism Amino acids and amines succinylglutamate-semialdehyde dehydrogenase (TIGR03240; EC 1.2.1.71; HMM-score: 35.8)
    Metabolism Energy metabolism Amino acids and amines putative delta-1-pyrroline-5-carboxylate dehydrogenase (TIGR01237; EC 1.2.1.88; HMM-score: 31.1)
    Metabolism Energy metabolism Other 2-hydroxymuconic semialdehyde dehydrogenase (TIGR03216; EC 1.2.1.-; HMM-score: 29.8)
    putative phosphonoacetaldehyde dehydrogenase (TIGR03250; EC 1.2.1.-; HMM-score: 29.5)
    Metabolism Energy metabolism Amino acids and amines methylmalonate-semialdehyde dehydrogenase (acylating) (TIGR01722; EC 1.2.1.27; HMM-score: 25.1)
    phenylacetic acid degradation protein paaN (TIGR02288; HMM-score: 24.4)
    Unknown function Enzymes of unknown specificity aldehyde dehydrogenase, Rv0768 family (TIGR04284; EC 1.2.1.-; HMM-score: 20.3)
    1-pyrroline dehydrogenase (TIGR03374; EC 1.2.1.19; HMM-score: 18.9)
  • TheSEED  :
    • Acetaldehyde dehydrogenase (EC 1.2.1.10)
    • Alcohol dehydrogenase (EC 1.1.1.1)
    Carbohydrates Central carbohydrate metabolism Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate  Acetaldehyde dehydrogenase (EC 1.2.1.10)
    and 4 more
    Carbohydrates Fermentation Fermentations: Lactate  Acetaldehyde dehydrogenase (EC 1.2.1.10)
    Carbohydrates Fermentation Fermentations: Mixed acid  Acetaldehyde dehydrogenase (EC 1.2.1.10)
    Carbohydrates Fermentation Fermentations: Mixed acid  Alcohol dehydrogenase (EC 1.1.1.1)
    Fatty Acids, Lipids, and Isoprenoids Phospholipids Glycerolipid and Glycerophospholipid Metabolism in Bacteria  Alcohol dehydrogenase (EC 1.1.1.1)
  • PFAM:
    DHQS (CL0224) Fe-ADH; Iron-containing alcohol dehydrogenase (PF00465; HMM-score: 384.8)
    and 3 more
    ALDH-like (CL0099) Aldedh; Aldehyde dehydrogenase family (PF00171; HMM-score: 95.6)
    DHQS (CL0224) Fe-ADH_2; Iron-containing alcohol dehydrogenase (PF13685; HMM-score: 60.4)
    TBP-like (CL0407) AdoMet_dc; S-adenosylmethionine decarboxylase (PF02675; HMM-score: 12.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002566
    • TAT(Tat/SPI): 0.000322
    • LIPO(Sec/SPII): 0.000354
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ADM85601 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKAMEENMADKKTVTPEEKKLVAEKHVDELVQKALVALEEMRKLDQEQVDYIVAKASVAALDAHGELALHAFEETGRGVFEDKATKNLFACEHVVNNMRHTKTVGVIEEDDVTGLTLIAEPVGVVCGITPTTNPTSTAIFKSLISLKTRNPIVFAFHPSAQESSAHAARIVRDAAIAAGAPENCVQWITQPSMEATSALMNHEGVATILATGGNAMVKAAYSCGKPALGVGAGNVPAYVEKSANIRQAAHDIVMSKSFDNGMVCASEQAVIIDKEIYDEFVAEFKSYHTYFVSKKEKALLEEFCFGVKANSKNCAGAKLNADIVGKPATWIAEQAGFTVPEGTNILAAECKEVGENEPLTREKLSPVIAVLKSESREDGITKARQMVEFNGLGHSAAIHTADEELTKEFGKAVKAIRVICNSPSTFGGIGDVYNAFLPSLTLGCGSYGRNSVGDNVSAINLLNIKKVGRRRNNMQWMKLPSKTYFERDSIQYLQKCRDVERVMIVTDHAMVELGFLDRIIEQLDLRRNKVVYQIFADVEPDPDITTVNRGTEIMRAFKPDTIIALGGGSPMDAAKVMWLFYEQPEVDFRDLVQKFMDIRKRAFKFPLLGKKTKFIAIPTTSGTGSEVTPFAVISDKANNRKYPIADYSLTPTVAIVDPALVLTVPGFVAADTGMDVLTHATEAYVSQMASDYTDGLALQAIKLVFENLESSVKNADFHSREKMHNASTIAGMAFANAFLGISHSMAHKIGAQFHTIHGRTNAILLPYVIRYNGTRPAKTATWPKYNYYRADEKYQDIARMLGLPASTPEEGVESYAKAVYELGERIGIQMNFRDQGIDEKEWKEHSRELAFLAYEDQCSPANPRLPMVDHMQEIIEDAYYGYKERPGRRK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Truc Thanh Luong, Eun-Hye Kim, Jong Phil Bak, Cuong Thach Nguyen, Sangdun Choi, David E Briles, Suhkneung Pyo, Dong-Kwon Rhee
Ethanol-induced alcohol dehydrogenase E (AdhE) potentiates pneumolysin in Streptococcus pneumoniae.
Infect Immun: 2015, 83(1);108-19
[PubMed:25312953] [WorldCat.org] [DOI] (I p)

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