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serotype 4
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70585
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serotype 14
JJA
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MDRSPN001
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NCTC7466
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serotype 4
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serotype 3
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SPN032672
serotype 1
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serotype 3
SPN034183
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SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
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TCH8431/19A
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serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 17-JAN-2018

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae AP200
  • locus tag: SPAP_2079 [new locus tag: SPAP_RS10300 ]
  • pan locus tag?: PNEUPAN003812000
  • symbol: SPAP_2079
  • pan gene symbol?: comGA
  • synonym:
  • product: Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPAP_2079 [new locus tag: SPAP_RS10300 ]
  • symbol: SPAP_2079
  • product: Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB
  • replicon: chromosome
  • strand: -
  • coordinates: 1930597..1931538
  • length: 942
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    ATGGTTCAAGAAATTGCACAAGAAATCATTCGCTCGGCTCGGAAAAAAGGGGCGCAAGAC
    ATTTATTTTGTCCCCAAGTTAGACGCCTATGAGCTTCATATGAGGGTAGGAGACGAGCGC
    TGTAAAATTGGTAGCTATGATTTTGAAAAGTTTGCAGCCGTTATCAGTCACTTTAAGTTT
    GTGGCGGGTATGAATGTGGGAGAAAAAAGACGTAGTCAACTGGGTTCCTGTGATTATGCC
    TATGACCAGAAGATGGCGTCTCTACGTTTATCTACTGTAGGCGATTATCGGGGGCATGAG
    AGTTTGGTTATCCGTTTGTTGCACGATGAGGAGCAGGACTTGCATTTTTGGTTTCAGGAT
    ATTGAAGAATTAGGCAAGCAGTACAGGCAACGGGGACTCTATCTTTTTGCTGGTCCGGTT
    GGGAGTGGTAAGACGACCTTGATGCATGAATTGTCCAAGTCACTCTTTAAAGGACAGCAA
    GTTATGTCCATCGAAGATCCTGTCGAAATCAAGCAGGACGACATGCTTCAGTTGCAGTTG
    AACGAAGCAATCGGTCTAACCTATGAAAATCTAATCAAACTTTCCTTGCGTCATCGACCA
    GATCTCTTGATTATCGGAGAAATTCGTGACATCGAGACGGCGCGTGCAGTGGTCAGAGCT
    AGTTTGACAGGTGCGACAGTCTTTTCAACCATTCACGCCAAGAGTATCCGAGGTGTTTAT
    GAGCGTCTGCTGGAGTTGGGTGTGAGTGAAGAAGAATTGGCAGTTGTTCTGCAAGGAGTC
    TGCTACCAGAGATTAATCGGGGGAGGAGGAATCGTTGACTTTGCAAACAGAGATTATCAA
    GAACACCAAGCAGCCAAGTGGAATGAGCAAATTGACCAGCTTCTTAAAGATGGACATATC
    ACAAGTCTTCAGGCTGAGACGGAAAAAATTAGCTACAGCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    942

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPAP_2079 [new locus tag: SPAP_RS10300 ]
  • symbol: SPAP_2079
  • description: Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB
  • length: 313
  • theoretical pI: 6.01371
  • theoretical MW: 35587.3
  • GRAVY: -0.307348

⊟Function[edit | edit source]

  • ⊞TIGRFAM:
    Cellular processes Cellular processes Pathogenesis type II secretion system protein E (TIGR02533; HMM-score: 147)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type II secretion system protein E (TIGR02533; HMM-score: 147)
    Cell structure Cell envelope Surface structures type IV-A pilus assembly ATPase PilB (TIGR02538; HMM-score: 128.7)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type IV-A pilus assembly ATPase PilB (TIGR02538; HMM-score: 128.7)
    and 21 more
    Cell structure Cell envelope Surface structures twitching motility protein (TIGR01420; HMM-score: 92.9)
    Cellular processes Cellular processes Chemotaxis and motility twitching motility protein (TIGR01420; HMM-score: 92.9)
    Genetic information processing Mobile and extrachromosomal element functions Plasmid functions plasmid transfer ATPase TraJ (TIGR02525; HMM-score: 63.3)
    P-type DNA transfer ATPase VirB11 (TIGR02788; HMM-score: 53.9)
    helicase/secretion neighborhood ATPase (TIGR03819; HMM-score: 50.7)
    Cellular processes Cellular processes Conjugation P-type conjugative transfer ATPase TrbB (TIGR02782; HMM-score: 48.7)
    Dot/Icm secretion system ATPase DotB (TIGR02524; HMM-score: 44.7)
    Cellular processes Cellular processes Sporulation and germination stage III sporulation protein AA (TIGR02858; HMM-score: 27)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking putative secretion ATPase, PEP-CTERM locus subfamily (TIGR03015; HMM-score: 23.1)
    Metabolism Central intermediary metabolism Nitrogen metabolism urease accessory protein UreG (TIGR00101; HMM-score: 17.1)
    Cellular processes Cellular processes Chemotaxis and motility flagellar biosynthesis protein FlhF (TIGR03499; HMM-score: 16.8)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair checkpoint protein rad24 (TIGR00602; HMM-score: 14.5)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA threonylcarbamoyl adenosine modification protein YjeE (TIGR00150; HMM-score: 13.1)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, subunit gamma and tau (TIGR02397; EC 2.7.7.7; HMM-score: 12.6)
    Genetic information processing Protein fate Protein folding and stabilization ATP-dependent chaperone protein ClpB (TIGR03346; HMM-score: 12.6)
    Cellular processes Cellular processes Cell division cell division ATP-binding protein FtsE (TIGR02673; HMM-score: 12.5)
    Metabolism Transport and binding proteins Anions phosphate ABC transporter, ATP-binding protein (TIGR00972; EC 3.6.3.27; HMM-score: 11.9)
    Cellular processes Cellular processes Other gas vesicle protein GvpN (TIGR02640; HMM-score: 11.8)
    Cellular processes Cellular processes Pathogenesis type VI secretion ATPase, ClpV1 family (TIGR03345; HMM-score: 11.8)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type VI secretion ATPase, ClpV1 family (TIGR03345; HMM-score: 11.8)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, delta' subunit (TIGR00678; EC 2.7.7.7; HMM-score: 11.6)
  • ⊞TheSEED  :
    • Late competence protein ComGA, access of DNA to ComEA
    DNA Metabolism DNA uptake, competence Gram Positive Competence  Late competence protein ComGA, access of DNA to ComEA
    and 1 more
    DNA Metabolism DNA uptake, competence Late competence  Late competence protein ComGA, access of DNA to ComEA
  • ⊞PFAM:
    P-loop_NTPase (CL0023) T2SSE; Type II/IV secretion system protein (PF00437; HMM-score: 168.7)
    and 30 more
    AAA_14; AAA domain (PF13173; HMM-score: 22.8)
    SRPRB; Signal recognition particle receptor beta subunit (PF09439; HMM-score: 20.4)
    Rad17; Rad17 P-loop domain (PF03215; HMM-score: 20.3)
    AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 19.7)
    TsaE; Threonylcarbamoyl adenosine biosynthesis protein TsaE (PF02367; HMM-score: 19.5)
    AAA_18; AAA domain (PF13238; HMM-score: 18.5)
    AAA_22; AAA domain (PF13401; HMM-score: 18)
    AAA_23; AAA domain (PF13476; HMM-score: 17.7)
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 16)
    AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 15.3)
    dNK; Deoxynucleoside kinase (PF01712; HMM-score: 15.2)
    AAA_5; AAA domain (dynein-related subfamily) (PF07728; HMM-score: 15.2)
    cobW; CobW/HypB/UreG, nucleotide-binding domain (PF02492; HMM-score: 15)
    Zeta_toxin; Zeta toxin (PF06414; HMM-score: 15)
    AAA_2; AAA domain (Cdc48 subfamily) (PF07724; HMM-score: 14.6)
    NTPase_1; NTPase (PF03266; HMM-score: 14.5)
    AFG1_ATPase; AFG1-like ATPase (PF03969; HMM-score: 14.4)
    ResIII; Type III restriction enzyme, res subunit (PF04851; HMM-score: 14.4)
    AAA_33; AAA domain (PF13671; HMM-score: 14.1)
    Roc; Ras of Complex, Roc, domain of DAPkinase (PF08477; HMM-score: 14)
    RNA_helicase; RNA helicase (PF00910; HMM-score: 13.7)
    AAA_30; AAA domain (PF13604; HMM-score: 13.5)
    ATP_bind_1; Conserved hypothetical ATP binding protein (PF03029; HMM-score: 13.4)
    AAA_7; P-loop containing dynein motor region (PF12775; HMM-score: 13.2)
    AAA_25; AAA domain (PF13481; HMM-score: 13.1)
    NACHT; NACHT domain (PF05729; HMM-score: 12.8)
    PduV-EutP; Ethanolamine utilisation - propanediol utilisation (PF10662; HMM-score: 12.5)
    APS_kinase; Adenylylsulphate kinase (PF01583; HMM-score: 12)
    Herpes_TK; Thymidine kinase from herpesvirus (PF00693; HMM-score: 11.9)
    AAA_PrkA; PrkA AAA domain (PF08298; HMM-score: 11.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.89
    • Cytoplasmic Membrane Score: 0.09
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.004211
    • TAT(Tat/SPI): 0.000328
    • LIPO(Sec/SPII): 0.000576
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ADM85628 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MVQEIAQEIIRSARKKGAQDIYFVPKLDAYELHMRVGDERCKIGSYDFEKFAAVISHFKFVAGMNVGEKRRSQLGSCDYAYDQKMASLRLSTVGDYRGHESLVIRLLHDEEQDLHFWFQDIEELGKQYRQRGLYLFAGPVGSGKTTLMHELSKSLFKGQQVMSIEDPVEIKQDDMLQLQLNEAIGLTYENLIKLSLRHRPDLLIIGEIRDIETARAVVRASLTGATVFSTIHAKSIRGVYERLLELGVSEEELAVVLQGVCYQRLIGGGGIVDFANRDYQEHQAAKWNEQIDQLLKDGHITSLQAETEKISYS

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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