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serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
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serotype 3
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serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 17-JAN-2018

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae AP200
  • locus tag: SPAP_2244 [new locus tag: SPAP_RS11095 ]
  • pan locus tag?: PNEUPAN003917000
  • symbol: SPAP_2244
  • pan gene symbol?: cbpD
  • synonym:
  • product: Choline binding protein D

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPAP_2244 [new locus tag: SPAP_RS11095 ]
  • symbol: SPAP_2244
  • product: Choline binding protein D
  • replicon: chromosome
  • strand: -
  • coordinates: 2089897..2091153
  • length: 1257
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    ATGCTAGCAGCTGGTGATAGTGTCTATGCCTATTCCAGAGGAAATGGATCGATTGCGCGT
    GGGGATGATTATCCTGCTTATTATAAAAATGGGAGCCAGGAGATTGATCAGTGGCGCATG
    TATTCTCGTCAGTGTACTTCTTTTGTAGCCTTTCGTTTGAGTAATGTCAATGGTTTTGAA
    ATGCCGGCAGCTTATGGAAATGCGAATGAATGGGGACATCGTGCTCGTCGGGAAGGTTAT
    CGTGTAGATAATACACCGACGATTGGTTCCATTACTTGGTCTACTGCAGGAACTTATGGT
    CATGTTGCCTGGGTGTCAAATGTAATGGGAGATCAGATTGAGATTGAGGAATATAACTAT
    GGTTATACAGAATCCTATAATAAACGAATTATAAAAGCAAACACGATGACAGGATTTATT
    CATTTTAAAGATTTGGATGGTGGCAGTGTTGGGAATAGTCAATCCTCAACTTCAACAGGC
    GGAACTCATTATTTTAAGACCAAGTCTGCTATTAAAACTGAACCCCTAGTTAGTGCAACT
    GTGATTGATTACTATTATCCTGGAGAGAAGGTTCATTATGATCAAATTCTCGAAAAAGAC
    GGCTACAAGTGGTTGAGTTATACTGCCTATAATGGAAGCTATCGTTATGTTCAATTGGAG
    GCTGTGAATAAAAATCCTCTAGGTCATTCTGTTCTTTCTTCAACAGGTGGAACTCATTAT
    TTTAAGACCAAGTCTGCTATCAAAACTGAACCCCTAGTTAGTGCAACTGTGATTGATTAC
    TATTATCCTGGGGAGAAGGTTCATTATGATCAGATACTTGAAAAAGACGGCTACAAGTGG
    TTGAGTTATACGGCTTATAACGGAAGTCGTCGCTATATACAGCTAGAGGGAGTGACTTCT
    TCACAAAATTATCAGAATCAATCAGGAAATATCTCTAGCTATGGATCCAATAATAGTTCA
    ACTGTCGGTTGGAAGAAAATAAATGGTAGTTGGTATCATTTCAAATCAAATGGTTATAAA
    TCAACAGGATGGCTGAAAGATGGTTCTAGCTGGTATTATTTGAAATTATCTGGTGAAATG
    CAGACAGGATGGTTAAAGGAGAATGGCTCGTGGTATTATCTGGGTAGTTCAGGGGCAATG
    AAAACAGGCTGGTACCAGGTCTCTGGTAAGTGGTATTATTCTTACTCTTCAGGCGCCTTA
    GCTGTTAATACGACGGTGGATGGCTACAGAGTAAACAGTGATGGAGAACGAGTATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1257

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPAP_2244 [new locus tag: SPAP_RS11095 ]
  • symbol: SPAP_2244
  • description: Choline binding protein D
  • length: 418
  • theoretical pI: 8.98089
  • theoretical MW: 47104.4
  • GRAVY: -0.699282

⊟Function[edit | edit source]

  • TIGRFAM:
    glucan-binding repeat (TIGR04035; HMM-score: 23.4)
  • TheSEED  :
    • Choline binding protein D
    Regulation and Cell signaling Programmed Cell Death and Toxin-antitoxin Systems Fratricide in Streptococcus  Choline binding protein D
    and 1 more
    Stress Response Osmotic stress Choline and Betaine Uptake and Betaine Biosynthesis  Choline binding protein D
  • PFAM:
    SH3 (CL0010) SH3_5; Bacterial SH3 domain (PF08460; HMM-score: 156.8)
    and 5 more
    Choline_binding (CL0694) Choline_bind_1; Putative cell wall binding repeat (PF01473; HMM-score: 83.8)
    Choline_bind_3; Choline-binding repeat (PF19127; HMM-score: 59.4)
    Peptidase_CA (CL0125) CHAP; CHAP domain (PF05257; HMM-score: 46)
    Choline_binding (CL0694) Choline_bind_2; Choline-binding repeat (PF19085; HMM-score: 23.8)
    EF_hand (CL0220) EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like (PF09279; HMM-score: 14)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.078774
    • TAT(Tat/SPI): 0.001535
    • LIPO(Sec/SPII): 0.012655
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ADM85775 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MLAAGDSVYAYSRGNGSIARGDDYPAYYKNGSQEIDQWRMYSRQCTSFVAFRLSNVNGFEMPAAYGNANEWGHRARREGYRVDNTPTIGSITWSTAGTYGHVAWVSNVMGDQIEIEEYNYGYTESYNKRIIKANTMTGFIHFKDLDGGSVGNSQSSTSTGGTHYFKTKSAIKTEPLVSATVIDYYYPGEKVHYDQILEKDGYKWLSYTAYNGSYRYVQLEAVNKNPLGHSVLSSTGGTHYFKTKSAIKTEPLVSATVIDYYYPGEKVHYDQILEKDGYKWLSYTAYNGSRRYIQLEGVTSSQNYQNQSGNISSYGSNNSSTVGWKKINGSWYHFKSNGYKSTGWLKDGSSWYYLKLSGEMQTGWLKENGSWYYLGSSGAMKTGWYQVSGKWYYSYSSGALAVNTTVDGYRVNSDGERV

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Vegard Eldholm, Ola Johnsborg, Kristine Haugen, Hilde Solheim Ohnstad, Leiv Sigve Håvarstein
Fratricide in Streptococcus pneumoniae: contributions and role of the cell wall hydrolases CbpD, LytA and LytC.
Microbiology (Reading): 2009, 155(Pt 7);2223-2234
[PubMed:19389766] [WorldCat.org] [DOI] (P p)

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