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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 22-FEB-2023

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae AP200
  • locus tag: SPAP_RS03655 [old locus tag: SPAP_0736 ]
  • pan locus tag?: PNEUPAN001702000
  • symbol: metK
  • pan gene symbol?: metK
  • synonym:
  • product: methionine adenosyltransferase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPAP_RS03655 [old locus tag: SPAP_0736 ]
  • symbol: metK
  • product: methionine adenosyltransferase
  • replicon: chromosome
  • strand: +
  • coordinates: 703935..705125
  • length: 1191
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: NC_014494 (703935..705125) NCBI
  • BioCyc: SPAP_RS03655 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0664 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    ATGTCAGAGCGTAAATTATTCACGTCTGAATCTGTATCTGAGGGGCATCCGGATAAGATT
    GCAGACCAAATTTCAGATGCGATTTTGGATGCTATTTTAGCAAAGGATCCAGAGGCGCAC
    GTTGCTGCTGAAACAGCTGTATATACTGGTTCTGTCCACGTTTTTGGTGAAATTTCTACA
    AATGCCTATGTGGATATTAACCGTGTGGTTCGTGATACCATTGCAGAGATTGGTTATACC
    AATACAGAATATGGATTTTCTGCTGAGACGGTGGGAGTACACCCATCTTTGGTGGAACAA
    TCTCCTGACATCGCTCAAGGTGTTAACGAAGCCTTGGAGGTTCGTGGAAATGCTGATCAA
    GATCCACTGGACTTGATTGGAGCAGGTGACCAAGGGCTCATGTTTGGATTTGCAGTAGAT
    GAAACAGAAGAGCTCATGCCATTGCCAATTGCACTCAGTCATAAATTGGTTCGTCGTCTG
    GCAGAACTTCGTAAGTCTGGAGAAATTAGCTATCTCCGTCCAGATGCAAAATCACAAGTT
    ACAGTTGAGTACGATGAAAATGACCGTCCGGTACGTGTAGATACAGTCGTTATTTCTACT
    CAGCATGATCCAGAGGCCACTAATGAACAAATCCATCAAGATGTGATTGACAAGGTCATC
    AAAGAAGTTATTCCATCTTCTTATCTTGATGATAAGACAAAATTCTTTATCAATCCGACA
    GGTCGTTTTGTAATCGGTGGTCCTCAAGGGGACTCAGGTTTGACTGGTCGTAAGATTATT
    GTAGATACTTATGGTGGCTACTCTCGTCATGGTGGTGGTGCCTTCTCTGGTAAAGATGCG
    ACTAAGGTGGATCGTTCAGCCTCTTATGCGGCTCGCTATATTGCCAAGAATATCGTTGCA
    GCAGACCTTGCTAAGAAGGCAGAAGTGCAGTTGGCCTATGCTATCGGTGTTGCGCAACCT
    GTTTCTGTTCGTATCGATACTTTCGGTACAGGAACAGTAGCTGAAAGTCAACTTGAAAAA
    GCGGCTCGTCAAATCTTTGACCTTCGCCCTGCAGGGATTATCCAAATGCTGGACCTCAAG
    CGTCCAATTTACCGTCAAACATCGGCTTACGGTCACATGGGACGTACAGATATTGATCTT
    CCATGGGAACGTTTGGATAAGGTAGATGCTTTGAAAGAAGCAGTAAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1191

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPAP_RS03655 [old locus tag: SPAP_0736 ]
  • symbol: MetK
  • description: methionine adenosyltransferase
  • length: 396
  • theoretical pI: 4.75305
  • theoretical MW: 43173.1
  • GRAVY: -0.283838

⊟Function[edit | edit source]

  • reaction:
    EC 2.5.1.6?  ExPASy
    Methionine adenosyltransferase ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine
  • TIGRFAM:
    Metabolism Central intermediary metabolism Other methionine adenosyltransferase (TIGR01034; EC 2.5.1.6; HMM-score: 583.1)
  • TheSEED: see SPAP_0736
  • PFAM:
    no clan defined S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain (PF02773; HMM-score: 227.3)
    and 3 more
    S-AdoMet_synt_M; S-adenosylmethionine synthetase, central domain (PF02772; HMM-score: 174.1)
    S-AdoMet_synt_N; S-adenosylmethionine synthetase, N-terminal domain (PF00438; HMM-score: 136.6)
    AdoMet_Synthase; S-adenosylmethionine synthetase (AdoMet synthetase) (PF01941; HMM-score: 13.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 10
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9593
    • Cytoplasmic Membrane Score: 0.0049
    • Cell wall & surface Score: 0.0004
    • Extracellular Score: 0.0355
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.005664
    • TAT(Tat/SPI): 0.000815
    • LIPO(Sec/SPII): 0.000604
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000003934 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSERKLFTSESVSEGHPDKIADQISDAILDAILAKDPEAHVAAETAVYTGSVHVFGEISTNAYVDINRVVRDTIAEIGYTNTEYGFSAETVGVHPSLVEQSPDIAQGVNEALEVRGNADQDPLDLIGAGDQGLMFGFAVDETEELMPLPIALSHKLVRRLAELRKSGEISYLRPDAKSQVTVEYDENDRPVRVDTVVISTQHDPEATNEQIHQDVIDKVIKEVIPSSYLDDKTKFFINPTGRFVIGGPQGDSGLTGRKIIVDTYGGYSRHGGGAFSGKDATKVDRSASYAARYIAKNIVAADLAKKAEVQLAYAIGVAQPVSVRIDTFGTGTVAESQLEKAARQIFDLRPAGIIQMLDLKRPIYRQTSAYGHMGRTDIDLPWERLDKVDALKEAVK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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