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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BM6001serotype 19F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7465serotype 1
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 05-APR-2025
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae JJA
- locus tag: SPJ_RS03495 [old locus tag: SPJ_0699 ]
- pan locus tag?: PNEUPAN001702000
- symbol: metK
- pan gene symbol?: metK
- synonym:
- product: methionine adenosyltransferase
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SPJ_RS03495 [old locus tag: SPJ_0699 ]
- symbol: metK
- product: methionine adenosyltransferase
- replicon: chromosome
- strand: +
- coordinates: 676464..677654
- length: 1191
- essential: unknown other strains
⊟Accession numbers[edit | edit source]
- Location: NC_012466 (676464..677654) NCBI
- BioCyc: SPJ_RS03495 BioCyc
- MicrobesOnline: see SPJ_0699
- PneumoBrowse for strain D39V: SPV_0664 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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1141ATGTCAGAGCGTAAATTATTCACGTCTGAATCTGTATCTGAGGGGCATCCGGATAAGATT
GCAGACCAAATTTCAGATGCGATTTTGGATGCTATTTTAGCAAAGGATCCAGAGGCGCAC
GTTGCTGCTGAAACAGCTGTATATACTGGTTCTGTCCACGTTTTTGGTGAAATTTCTACA
AATGCCTATGTGGATATTAACCGTGTGGTTCGTGATACCATTGCAGAGATTGGTTATACC
AATACAGAATATGGATTTTCTGCTGAGACGGTGGGAGTACACCCATCTTTGGTGGAACAA
TCTCCTGACATCGCTCAAGGTGTTAACGAAGCCTTGGAGGTTCGTGGAAATGCTGATCAA
GATCCACTGGACTTGATTGGAGCAGGTGACCAAGGGCTCATGTTTGGATTTGCAGTAGAT
GAAACAGAAGAGCTCATGCCATTGCCAATTGCACTCAGTCATAAATTGGTTCGTCGTCTG
GCAGAACTTCGTAAGTCTGAAGAAATTAGCTATCTCCGTCCAGATGCAAAATCACAAGTT
ACAGTTGAGTACGATGAAAATGACCGTCCGGTACGTGTAGATACAGTCGTTATTTCTACT
CAGCATGATCCAGAGGCCACTAATGAACAAATCCATCAAGATGTGATTAAAAAGGTCATC
AAAGAAGTTATTCCATCTTCTTATCTTGATGATAAGACAAAATTCTTTATCAATCCGACA
GGTCGTTTTGTAATCGGTGGTCCTCAAGGGGACTCAGGTTTGACTGGTCGTAAGATTATT
GTAGATACTTATGGTGGCTACTCTCGTCATGGTGGTGGTGCCTTCTCTGGTAAAGATGCG
ACTAAGGTGGATCGTTCAGCCTCTTATGCGGCTCGCTATATTGCCAAGAATATCGTTGCA
GCAGACCTTGCTAAGAAGGCAGAAGTGCAGTTGGCCTATGCTATCGGTGTTGCGCAACCT
GTTTCTGTTCGTATCGATACTTTCGGTACAGGAACAGTAGCTGAAAGTCAACTTGAAAAA
GCGGCTCGTCAAATCTTTGACCTTCGCCCTGCAGGGATTATCCAAATGCTGGACCTCAAG
CGTCCAATTTACCGTCAAACATCGGCTTACGGTCACATGGGACGTACAGATATTGATCTT
CCATGGGAACGTTTGGATAAGGTAGATGCTTTGAAAGAAGCAGTAAAATAA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SPJ_RS03495 [old locus tag: SPJ_0699 ]
- symbol: MetK
- description: methionine adenosyltransferase
- length: 396
- theoretical pI: 4.81365
- theoretical MW: 43258.3
- GRAVY: -0.292677
⊟Function[edit | edit source]
- reaction: EC 2.5.1.6? ExPASyMethionine adenosyltransferase ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine
- TIGRFAM: Central intermediary metabolism Other methionine adenosyltransferase (TIGR01034; EC 2.5.1.6; HMM-score: 581.1)
- TheSEED: see SPJ_0699
- PFAM: no clan defined S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain (PF02773; HMM-score: 227.3)and 3 moreS-AdoMet_synt_M; S-adenosylmethionine synthetase, central domain (PF02772; HMM-score: 174.5)S-AdoMet_synt_N; S-adenosylmethionine synthetase, N-terminal domain (PF00438; HMM-score: 137.7)AdoMet_Synthase; S-adenosylmethionine synthetase (AdoMet synthetase) (PF01941; HMM-score: 13.7)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 9.97
- Cytoplasmic Membrane Score: 0
- Cellwall Score: 0.01
- Extracellular Score: 0.02
- Internal Helices: 0
- DeepLocPro: Cytoplasmic
- Cytoplasmic Score: 0.9572
- Cytoplasmic Membrane Score: 0.0062
- Cell wall & surface Score: 0.0005
- Extracellular Score: 0.0362
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.005664
- TAT(Tat/SPI): 0.000815
- LIPO(Sec/SPII): 0.000604
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MSERKLFTSESVSEGHPDKIADQISDAILDAILAKDPEAHVAAETAVYTGSVHVFGEISTNAYVDINRVVRDTIAEIGYTNTEYGFSAETVGVHPSLVEQSPDIAQGVNEALEVRGNADQDPLDLIGAGDQGLMFGFAVDETEELMPLPIALSHKLVRRLAELRKSEEISYLRPDAKSQVTVEYDENDRPVRVDTVVISTQHDPEATNEQIHQDVIKKVIKEVIPSSYLDDKTKFFINPTGRFVIGGPQGDSGLTGRKIIVDTYGGYSRHGGGAFSGKDATKVDRSASYAARYIAKNIVAADLAKKAEVQLAYAIGVAQPVSVRIDTFGTGTVAESQLEKAARQIFDLRPAGIIQMLDLKRPIYRQTSAYGHMGRTDIDLPWERLDKVDALKEAVK
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
- MicrobesOnline: no polycistronic organisation predicted
⊟Regulation[edit | edit source]
- regulator:
⊟Transcription[edit | edit source]
- transcription start site:
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_0664 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You can add further information about the gene and protein here. [edit]