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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 07-FEB-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae AP200
  • locus tag: SPAP_RS05430 [old locus tag: SPAP_1095 ]
  • pan locus tag?: PNEUPAN002246000
  • symbol: SPAP_RS05430
  • pan gene symbol?: ppnK
  • synonym:
  • product: NAD kinase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPAP_RS05430 [old locus tag: SPAP_1095 ]
  • symbol: SPAP_RS05430
  • product: NAD kinase
  • replicon: chromosome
  • strand: -
  • coordinates: 1046227..1047045
  • length: 819
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: NC_014494 (1046227..1047045) NCBI
  • BioCyc: SPAP_RS05430 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0983 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    ATGAAGAATACAGGTAAACGAATTGATCTGATAGCCAATAGAAAACCGCAGAGTCAAAGG
    GTTTTGTATGAATTGCGAGATCGTTTGAAGAGAAATCAGTTTATACTCAATGATACCAAT
    CCGGATATTGTCATTTCCATTGGCGGGGATGGTATGCTCTTGTCGGCCTTTCATAAGTAC
    GAAAATCAGCTTGACAAGGTCCGCTTTATCGGTCTTCATACTGGACATTTGGGCTTCTAT
    ACAGATTATCGTGATTTTGAGTTGGACAAGCTAGTGACTAATTTGCAGCTAGATACTGGG
    GCAAGGGTTTCTTACCCTGTTCTGAATGTGAAGGTCTTTCTTGAAAATGGTGAAGTTAAG
    ATTTTCAGAGCACTCAACGAAGCCAGCATCCGCAGGTCTGATCGAACCATGGTGGCAGAT
    ATTGTAATAAATGGTGTTCCCTTTGAACGTTTTCGTGGAGACGGGCTAACAGTTTCGACA
    CCGACTGGTAGTACTGCCTATAACAAGTCTCTTGGCGGTGCTGTTTTACACCCTACCATT
    GAAGCTTTGCAATTAACGGAAATTGCCAGCCTTAATAATCGTGTTTATCGAACACTGGGC
    TCTTCCATTATTGTGCCTAAGAAGGATAAGATTGAACTTATTCCAACAAGAAACGATTAT
    CATACTATTTCGGTTGACAATAGCGTTTATTCTTTCCGTAATATTGAGCGTATTGAGTAT
    CAAATCGACCATCATAAGATTCACTTTGTCGCGACTCCTAGCCATACCAGTTTCTGGAAC
    CGTGTTAAGGATGCCTTTATCGGTGAGGTGGATGAATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    819

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPAP_RS05430 [old locus tag: SPAP_1095 ]
  • symbol: SPAP_RS05430
  • description: NAD kinase
  • length: 272
  • theoretical pI: 9.37752
  • theoretical MW: 31035
  • GRAVY: -0.351838

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.1.23?  ExPASy
    NAD+ kinase ATP + NAD+ = ADP + NADP+
  • TIGRFAM:
  • TheSEED: see SPAP_1095
  • PFAM:
    NAD_kinase_C (CL0701) NAD_kinase_C; ATP-NAD kinase C-terminal domain (PF20143; HMM-score: 45.3)
    and 2 more
    PFK (CL0240) NAD_kinase; ATP-NAD kinase N-terminal domain (PF01513; HMM-score: 24.3)
    Zn_Beta_Ribbon (CL0167) DUF1936; Domain of unknown function (DUF1936) (PF09151; HMM-score: 12.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.67
    • Cytoplasmic Membrane Score: 0.01
    • Cellwall Score: 0.15
    • Extracellular Score: 0.17
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.004993
    • TAT(Tat/SPI): 0.000222
    • LIPO(Sec/SPII): 0.00053
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000799053 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKNTGKRIDLIANRKPQSQRVLYELRDRLKRNQFILNDTNPDIVISIGGDGMLLSAFHKYENQLDKVRFIGLHTGHLGFYTDYRDFELDKLVTNLQLDTGARVSYPVLNVKVFLENGEVKIFRALNEASIRRSDRTMVADIVINGVPFERFRGDGLTVSTPTGSTAYNKSLGGAVLHPTIEALQLTEIASLNNRVYRTLGSSIIVPKKDKIELIPTRNDYHTISVDNSVYSFRNIERIEYQIDHHKIHFVATPSHTSFWNRVKDAFIGEVDE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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