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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 07-FEB-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae AP200
  • locus tag: SPAP_RS08620 [old locus tag: SPAP_1738 ]
  • pan locus tag?: PNEUPAN003141000
  • symbol: SPAP_RS08620
  • pan gene symbol?: phpP
  • synonym:
  • product: Stp1/IreP family PP2C-type Ser/Thr phosphatase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPAP_RS08620 [old locus tag: SPAP_1738 ]
  • symbol: SPAP_RS08620
  • product: Stp1/IreP family PP2C-type Ser/Thr phosphatase
  • replicon: chromosome
  • strand: -
  • coordinates: 1644809..1645549
  • length: 741
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_014494 (1644809..1645549) NCBI
  • BioCyc: SPAP_RS08620 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1543 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    ATGGAAATTTCATTATTAACAGATGTTGGTCAGAAACGAACAAATAACCAAGACTATGTC
    AACCACTATGTCAATAGAGCTGGACGTACCATGATTATTTTAGCTGATGGGATGGGAGGT
    CATCGTGCAGGGAATATCGCTAGTGAAATGGCGGTCACAGACCTGGGTGTAGCTTGGGTT
    GATACCCAGATCGATACAGTCAATGAAGTGCGTGAATGGTTCGCCCATTACCTAGAAATT
    GAAAATCAAAAGATTCACCAGCTTGGTCAGGATGAAGCTTACAGAGGTATGGGAACTACT
    TTGGAAGTCCTTGCTATTATTGATAATCAGGCTATCTATGCTCATATTGGTGATTCGCGT
    ATCGGCTTGATTCGTGGAGAAGAATACCATCAGTTGACGAGCGATCATTCCTTGGTTAAT
    GAATTGCTCAAGGCTGGTCAATTGACACCAGAAGAGGCAGAAGCTCATCCGCAAAAAAAT
    ATTATCACCCAGTCTATTGGGCAAAAAGATGAAATTCAGCCTGATTTTGGGACAGTTATC
    CTTGAGTCAGGTGACTATCTCTTGCTCAATAGTGACGGCTTGACCAACATGATTTCAGGC
    AGTGAGATTCGTGATATTGTAACCAGTGATATTCCTTTAGCAGATAAAACGGAGACACTT
    GTTCGTTTTGCTAACAATGCAGGAGGTTTAGACAACATTACGGTTGCCCTTGTTTCTATG
    AACGAGGAGGATGAAGAATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    741

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPAP_RS08620 [old locus tag: SPAP_1738 ]
  • symbol: SPAP_RS08620
  • description: Stp1/IreP family PP2C-type Ser/Thr phosphatase
  • length: 246
  • theoretical pI: 4.16689
  • theoretical MW: 27161
  • GRAVY: -0.317886

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Transcription Degradation of RNA regulator of ribonuclease activity A (TIGR02998; HMM-score: 13)
    Signal transduction Regulatory functions Protein interactions regulator of ribonuclease activity A (TIGR02998; HMM-score: 13)
  • TheSEED: see SPAP_1738
  • ⊞PFAM:
    PP2C (CL0238) PP2C_2; Protein phosphatase 2C (PF13672; HMM-score: 61.3)
    and 3 more
    PP2C; Protein phosphatase 2C (PF00481; HMM-score: 39.8)
    SpoIIE; Stage II sporulation protein E (SpoIIE) (PF07228; HMM-score: 18.5)
    no clan defined Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein (PF11414; HMM-score: 14.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.007105
    • TAT(Tat/SPI): 0.001069
    • LIPO(Sec/SPII): 0.000464
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000406248 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MEISLLTDVGQKRTNNQDYVNHYVNRAGRTMIILADGMGGHRAGNIASEMAVTDLGVAWVDTQIDTVNEVREWFAHYLEIENQKIHQLGQDEAYRGMGTTLEVLAIIDNQAIYAHIGDSRIGLIRGEEYHQLTSDHSLVNELLKAGQLTPEEAEAHPQKNIITQSIGQKDEIQPDFGTVILESGDYLLLNSDGLTNMISGSEIRDIVTSDIPLADKTETLVRFANNAGGLDNITVALVSMNEEDEE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Linda Nováková, Lenka Sasková, Petra Pallová, Jirí Janecek, Jana Novotná, Ales Ulrych, Jose Echenique, Marie-Claude Trombe, Pavel Branny
Characterization of a eukaryotic type serine/threonine protein kinase and protein phosphatase of Streptococcus pneumoniae and identification of kinase substrates.
FEBS J: 2005, 272(5);1243-54
[PubMed:15720398] [WorldCat.org] [DOI] (P p)Makoto Osaki, Tania Arcondéguy, Amandine Bastide, Christian Touriol, Hervé Prats, Marie-Claude Trombe
The StkP/PhpP signaling couple in Streptococcus pneumoniae: cellular organization and physiological characterization.
J Bacteriol: 2009, 191(15);4943-50
[PubMed:19502404] [WorldCat.org] [DOI] (I p)

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