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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 22-FEB-2023

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae AP200
  • locus tag: SPAP_RS08705 [old locus tag: SPAP_1756 ]
  • pan locus tag?: PNEUPAN003180000
  • symbol: SPAP_RS08705
  • pan gene symbol?: yqeG
  • synonym:
  • product: YqeG family HAD IIIA-type phosphatase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPAP_RS08705 [old locus tag: SPAP_1756 ]
  • symbol: SPAP_RS08705
  • product: YqeG family HAD IIIA-type phosphatase
  • replicon: chromosome
  • strand: -
  • coordinates: 1659661..1660188
  • length: 528
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: NC_014494 (1659661..1660188) NCBI
  • BioCyc: SPAP_RS08705 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1560 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    ATGGCGATTGAAAATTATATACCAGATTTTGCTGTGGAAGCAGTCTATGATCTGACAGTC
    CCAAGCCTGCAGGCGCAGGGAATCAAGGCTGTTTTGGTCGATTTGGATAATACCCTCATT
    GCTTGGAACAACCCTGATGGAACGCCAGAGATGAAGCAATGGCTACATGACCTTCGGGAC
    GCGGGTATTGGCATTATCGTAGTGTCAAATAACACCAAAAAACGCGTTCAACGAGCAGTT
    GAGAAATTTGGGATTGATTACGTTTACTGGGCCTTGAAGCCCTTCACATTTGGTATTGAC
    CGTGCTATGAAGGAATTCCACTATGACAAAAAGGAAGTGGTCATGGTTGGCGACCAGCTC
    ATGACAGATATACGAGCAGCCCACCGTGCAGGGATTCGGTCAATTTTAGTCAAACCCTTG
    GTCCAACATGACTCAATCAAAACGCAGATTAACCGAACTCGTGAGCGTCGTGTTATGAGA
    AAAATCACTGAAAAGTACGGACCGATTACATATAAAAAAGGAATTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    528

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPAP_RS08705 [old locus tag: SPAP_1756 ]
  • symbol: SPAP_RS08705
  • description: YqeG family HAD IIIA-type phosphatase
  • length: 175
  • theoretical pI: 9.98169
  • theoretical MW: 20100.2
  • GRAVY: -0.289714

⊟Function[edit | edit source]

  • TIGRFAM:
    HAD phosphatase, family IIIA (TIGR01668; EC 3.1.3.-; HMM-score: 135.5)
    and 34 more
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IIIA (TIGR01662; HMM-score: 70.9)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IIA (TIGR01460; HMM-score: 49.3)
    HAD hydrolase, TIGR02253 family (TIGR02253; HMM-score: 45.1)
    Unknown function Enzymes of unknown specificity HAD hydrolase, TIGR01457 family (TIGR01457; HMM-score: 44.2)
    phosphoglycolate/pyridoxal phosphate phosphatase family (TIGR01452; EC 3.1.3.18; HMM-score: 32.7)
    HAD hydrolase, REG-2-like, family IA (TIGR02252; HMM-score: 30.8)
    Unknown function Enzymes of unknown specificity HAD hydrolase, TIGR01458 family (TIGR01458; HMM-score: 29.7)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IA, variant 3 (TIGR01509; HMM-score: 29.3)
    noncanonical pyrimidine nucleotidase, YjjG family (TIGR02254; EC 3.1.3.5; HMM-score: 27.9)
    HAD hydrolase, TIGR01459 family (TIGR01459; HMM-score: 27.8)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IIB (TIGR01484; HMM-score: 27.1)
    histidinol-phosphate phosphatase domain (TIGR01656; HMM-score: 27.1)
    HAD phosphatase, family IIIC (TIGR01681; HMM-score: 27)
    haloacid dehalogenase, type II (TIGR01428; EC 3.8.1.2; HMM-score: 25.1)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IA, variant 1 (TIGR01549; HMM-score: 25.1)
    mannosyl-3-phosphoglycerate phosphatase family (TIGR01486; EC 3.1.3.-; HMM-score: 23.4)
    Unknown function Enzymes of unknown specificity Cof-like hydrolase (TIGR00099; HMM-score: 23.1)
    AHBA synthesis associated protein (TIGR01454; HMM-score: 18.3)
    phosphoglycolate phosphatase, TA0175-type (TIGR01487; EC 3.1.3.18; HMM-score: 18.1)
    pyrimidine 5'-nucleotidase (TIGR01993; EC 3.1.3.5; HMM-score: 18)
    Metabolism Energy metabolism Sugars phosphoglycolate phosphatase, bacterial (TIGR01449; EC 3.1.3.18; HMM-score: 17.8)
    Unknown function Enzymes of unknown specificity HAD phosphoserine phosphatase-like hydrolase, family IB (TIGR01488; HMM-score: 17.6)
    mannosyl-3-phosphoglycerate phosphatase (TIGR02461; EC 3.1.3.70; HMM-score: 16.5)
    viral phosphatase (TIGR01684; HMM-score: 16.3)
    Unknown function General mannosyl-3-phosphoglycerate phosphatase homolog (TIGR02463; EC 3.1.3.-; HMM-score: 15.2)
    HAD hydrolase, TIGR01456 family (TIGR01456; HMM-score: 14.7)
    heavy metal translocating P-type ATPase (TIGR01525; EC 3.6.3.-; HMM-score: 14.7)
    Cellular processes Cellular processes Detoxification copper-translocating P-type ATPase (TIGR01511; EC 3.6.3.4; HMM-score: 14)
    Metabolism Transport and binding proteins Cations and iron carrying compounds copper-translocating P-type ATPase (TIGR01511; EC 3.6.3.4; HMM-score: 14)
    HAD hydrolase, TIGR01548 family (TIGR01548; HMM-score: 13.8)
    Metabolism Amino acid biosynthesis Serine family phosphoserine phosphatase SerB (TIGR00338; EC 3.1.3.3; HMM-score: 13.5)
    Metabolism Amino acid biosynthesis Histidine family histidinol-phosphatase (TIGR01261; EC 3.1.3.15; HMM-score: 12)
    FkbH domain (TIGR01686; HMM-score: 12)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides D,D-heptose 1,7-bisphosphate phosphatase (TIGR00213; HMM-score: 11.9)
  • TheSEED: see SPAP_1756
  • PFAM:
    HAD (CL0137) HAD_2; haloacid dehalogenase-like hydrolase (PF13419; HMM-score: 60.2)
    Hydrolase; haloacid dehalogenase-like hydrolase (PF00702; HMM-score: 51.2)
    Hydrolase_like; HAD-hyrolase-like (PF13242; HMM-score: 50.9)
    and 11 more
    PGP_phosphatase; Mitochondrial PGP phosphatase (PF09419; HMM-score: 43.7)
    Hydrolase_6; haloacid dehalogenase-like hydrolase (PF13344; HMM-score: 21.5)
    Hydrolase_3; haloacid dehalogenase-like hydrolase (PF08282; HMM-score: 19.6)
    TPR (CL0020) VPS53_C; Vacuolar protein sorting-associated protein 53 C-terminus (PF16854; HMM-score: 18.8)
    HAD (CL0137) HAD; haloacid dehalogenase-like hydrolase (PF12710; HMM-score: 18)
    no clan defined DUF6555; Family of unknown function (DUF6555) (PF20192; HMM-score: 17.8)
    HAD (CL0137) DUF705; Protein of unknown function (DUF705) (PF05152; HMM-score: 16.3)
    Acid_phosphat_B; HAD superfamily, subfamily IIIB (Acid phosphatase) (PF03767; HMM-score: 14.4)
    Thioredoxin (CL0172) AhpC-TSA; AhpC/TSA family (PF00578; HMM-score: 13.6)
    HAD (CL0137) S6PP; Sucrose-6F-phosphate phosphohydrolase (PF05116; HMM-score: 12.5)
    PLP_aminotran (CL0061) SepSecS; O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS (PF05889; HMM-score: 11.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.2367
    • Cytoplasmic Membrane Score: 0.7578
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0054
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.005889
    • TAT(Tat/SPI): 0.000221
    • LIPO(Sec/SPII): 0.000531
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000963728 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MAIENYIPDFAVEAVYDLTVPSLQAQGIKAVLVDLDNTLIAWNNPDGTPEMKQWLHDLRDAGIGIIVVSNNTKKRVQRAVEKFGIDYVYWALKPFTFGIDRAMKEFHYDKKEVVMVGDQLMTDIRAAHRAGIRSILVKPLVQHDSIKTQINRTRERRVMRKITEKYGPITYKKGI

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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