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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 30-JAN-2014
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae CGSP14
- locus tag: SPCG_2010 [new locus tag: SPCG_RS10585 ]
- pan locus tag?: PNEUPAN003614000
- symbol: SPCG_2010
- pan gene symbol?: ackA
- synonym:
- product: acetate kinase
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SPCG_2010 [new locus tag: SPCG_RS10585 ]
- symbol: SPCG_2010
- product: acetate kinase
- replicon: chromosome
- strand: -
- coordinates: 1994596..1995816
- length: 1221
- essential: unknown
⊟Accession numbers[edit | edit source]
- Location: CP001033 (1994596..1995816) NCBI
- BioCyc: see SPCG_RS10585
- MicrobesOnline: 5761383 MicrobesOnline
- PneumoBrowse for strain D39V: SPV_1853 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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1201TTGAAAACGCTTAAAAAGGGGTATCATGTTATGACAAAAACAATTGCAATCAATGCAGGA
AGTTCAAGTTTGAAATGGCAATTATACTTAATGCCAGAAGAAAAAGTATTGGCGAAAGGT
TTGATTGAACGTATCGGTTTGAAAGATTCAATTTCAACTGTAAAATTTGACGGCCGTTCT
GAACAACAAATTTTGGATATTGAAAATCATACACAAGCCGTTAAAATTTTATTGGATGAC
TTGATTCGTTTCGATATTATCAAGGCTTATGACGAGATTACAGGTGTTGGACATCGTGTT
GTTGCTGGTGGAGAATATTTCAAAGAATCAACAGTTGTTGAGGGAGATGTTTTAGAAAAA
GTTGAAGAGTTGAGTTTGTTGGCTCCTCTACACAACCCGGCCAATGCAGCAGGTGTTCGT
GCCTTCAAGGAATTGTTGCCAGACATTACCAGTGTAGTTGTTTTTGATACTTCCTTCCAC
ACAAGTATGCCAGAGAAAGCTTATCGCTACCCTCTACCAACAAAATATTACACAGAAAAC
AAGGTTCGTAAATACGGTGCTCATGGTACAAGTCACCAGTTTGTAGCAGGAGAAGCTGCA
AAACTCTTGGGACGTCCATTAGAAGACTTGAAGTTAATTACCTGTCATATTGGTAACGGA
GGCTCAATTACAGCTGTGAAAGCCGGCAAATCTGTAGACACTTCTATGGGGTTCACTCCT
CTTGGTGGTATTATGATGGGAACGCGTACAGGGGATATTGATCCAGCTATCATTCCTTAT
TTAATGCAATATACAGAGGATTTTAACACACCAGAAGATATCAGTCGTGTTCTTAACCGT
GAATCAGGTCTTCTGGGAGTTTCTGCTAATTCTAGCGATATGCGCGATATAGAAGCAGCT
GTAGCAGAAGGGAATCACGAGGCTAGCTTGGCTTATGAAATGTATGTTGACCGTATCCAA
AAACATATCGGTCAGTACCTTGCAGTGCTAAATGGAGCAGATGCCATTGTTTTCACAGCA
GGTGTCGGTGAAAATGCAGAGAGTTTCCGTCGTGATGTAATCTCAGGGATTTCGTGGTTT
GGTTGTGATGTTGATGATGAAAAGAATGTCTTTGGCGTTACAGGAGACATCTCAACAGAG
GCAGCTAAAATCCGTGTCTTGGTTATTCCAACAGATGAAGAATTAGTCATTGCCCGTGAC
GTTGAACGCTTGAAAAAATAA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SPCG_2010 [new locus tag: SPCG_RS10585 ]
- symbol: SPCG_2010
- description: acetate kinase
- length: 406
- theoretical pI: 5.21321
- theoretical MW: 44516.5
- GRAVY: -0.128079
⊟Function[edit | edit source]
- TIGRFAM: Energy metabolism Fermentation acetate kinase (TIGR00016; EC 2.7.2.1; HMM-score: 508)and 1 moreEnergy metabolism Fermentation butyrate kinase (TIGR02707; EC 2.7.2.7; HMM-score: 67.6)
- TheSEED :
- Acetate kinase (EC 2.7.2.1)
Carbohydrates Central carbohydrate metabolism Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate Acetate kinase (EC 2.7.2.1)and 2 more - PFAM: Actin_ATPase (CL0108) Acetate_kinase; Acetokinase family (PF00871; HMM-score: 501.1)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 9.97
- Cytoplasmic Membrane Score: 0
- Cellwall Score: 0.01
- Extracellular Score: 0.02
- Internal Helices: 0
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.016994
- TAT(Tat/SPI): 0.000531
- LIPO(Sec/SPII): 0.001425
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MKTLKKGYHVMTKTIAINAGSSSLKWQLYLMPEEKVLAKGLIERIGLKDSISTVKFDGRSEQQILDIENHTQAVKILLDDLIRFDIIKAYDEITGVGHRVVAGGEYFKESTVVEGDVLEKVEELSLLAPLHNPANAAGVRAFKELLPDITSVVVFDTSFHTSMPEKAYRYPLPTKYYTENKVRKYGAHGTSHQFVAGEAAKLLGRPLEDLKLITCHIGNGGSITAVKAGKSVDTSMGFTPLGGIMMGTRTGDIDPAIIPYLMQYTEDFNTPEDISRVLNRESGLLGVSANSSDMRDIEAAVAEGNHEASLAYEMYVDRIQKHIGQYLAVLNGADAIVFTAGVGENAESFRRDVISGISWFGCDVDDEKNVFGVTGDISTEAAKIRVLVIPTDEELVIARDVERLKK
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- regulator: CcpA regulon
CcpA (TF) important in Global catabolite repression; RegPrecise
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_1853 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You are kindly invited to share additional interesting facts.
⊟Literature[edit | edit source]
⊟References[edit | edit source]
⊟Relevant publications[edit | edit source]
Smirla Ramos-Montañez, Krystyna M Kazmierczak, Kristy L Hentchel, Malcolm E Winkler
Instability of ackA (acetate kinase) mutations and their effects on acetyl phosphate and ATP amounts in Streptococcus pneumoniae D39.
J Bacteriol: 2010, 192(24);6390-400
[PubMed:20952579] [WorldCat.org] [DOI] (I p)