PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 24-JAN-2021

⊟Summary

• organism: Streptococcus pneumoniae CGSP14
• locus tag: SPCG_RS04975 [old locus tag: SPCG_0956 ]
• pan locus tag^?: PNEUPAN002009000
• symbol: prsA
• pan gene symbol^?: prsA
• synonym:
• product: peptidylprolyl isomerase PrsA

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPCG_RS04975 [old locus tag: SPCG_0956 ]
• symbol: prsA
• product: peptidylprolyl isomerase PrsA
• replicon: chromosome
• strand: +
• coordinates: 935947..936888
• length: 942
• essential: unknown

⊟Accession numbers

• Location: NC_010582 (935947..936888) NCBI
• BioCyc: SPCG_RS04975 BioCyc
• MicrobesOnline: see SPCG_0956
• PneumoBrowse for strain D39V: SPV_0868 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  
  ATGAAGAAAAAATTATTGGCAGGTGCCATCACACTATTATCAGTAGCAACTTTAGCAGCT
  TGTTCGAAAGGGTCAGAAGGTGCAGACCTTATCAGCATGAAAGGGGATGTCATTACAGAA
  CATCAATTTTATGAGCAAGTGAAAAGCAACCCTTCAGCCCAACAAGTCTTGTTAAATATG
  ACCATCCAAAAAGTTTTTGAAAAACAATATGGCTCAGAGCTTGATGATAAAGAGGTTGAT
  GATACTATTGCCGAAGAAAAAAAACAATATGGCGAAAACTACCAACGTGTCTTGTCACAA
  GCAGGTATGACTCTTGAAACACGTAAAGCTCAAATTCGTACAAGTAAATTAGTTGAGTTG
  GCAGTTAAGAAGGTAGCAGAAGCTGAATTGACAGATGAAGCCTATAAGAAAGCCTTTGAT
  GAGTACACTCCAGATGTAACGGCTCAAATCATCCGTCTTAATAATGAAGATAAGGCCAAA
  GAAGTTCTCGAAAAAGCCAAGGCAGAAGGTGCTGATTTTGCTCAATTAGCCAAAGATAAT
  TCAACTGATGAAAAAACAAAAGAAAATGGTGGAGAAATTACCTTTGATTCTGCTTCAACA
  GAAGTACCTGAGCAAGTCAAAAAAGCCGCTTTCGCTTTAGATGTGGATGGTGTTTCTGAT
  GTGATTACAGCAACTGGCACACAAGCCTACAGTAGCCAATATTACATTGTAAAACTCACT
  AAGAAAACAGAAAAATCATCTAATATTGATGACTACAAAGAAAAATTAAAAACTGTTATC
  TTGACTCAAAAACAAAATGATTCAACATTTGTTCAAAGCATTATCGGAAAAGAATTGCAA
  GCAGCCAATATCAAGGTTAAGGACCAAGCCTTCCAAAATATCTTTACCCAATATATCGGT
  GGTGGAGATTCAAGCTCAAGCAGTAGTACATCAAACGAATAG
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  840
  900
  942
  

⊟Protein

⊟General

• locus tag: SPCG_RS04975 [old locus tag: SPCG_0956 ]
• symbol: PrsA
• description: peptidylprolyl isomerase PrsA
• length: 313
• theoretical pI: 4.74303
• theoretical MW: 34412.3
• GRAVY: -0.573163

⊟Function

• reaction:
  EC 5.2.1.8?  ExPASy
  Peptidylprolyl isomerase Peptidylproline (omega=180) = peptidylproline (omega=0)
• TIGRFAM:
• TheSEED: see SPCG_0956
• PFAM:
  FKBP (CL0487) Rotamase_2; PPIC-type PPIASE domain (PF13145; HMM-score: 45.9)
  Rotamase; PPIC-type PPIASE domain (PF00639; HMM-score: 43.4)
  Rotamase_3; PPIC-type PPIASE domain (PF13616; HMM-score: 39.8)
  and 5 more
  no clan defined DUF4823; Domain of unknown function (DUF4823) (PF16105; HMM-score: 17.2)
  Trigger_C (CL0262) Trigger_C; Bacterial trigger factor protein (TF) C-terminus (PF05698; HMM-score: 16.8)
  SurA_N; SurA N-terminal domain (PF09312; HMM-score: 10.5)
  no clan defined DUF4473; Domain of unknown function (DUF4473) (PF14747; HMM-score: 9)
  Trigger_C (CL0262) SurA_N_3; SurA N-terminal domain (PF13624; HMM-score: 7)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic Membrane
  • Cytoplasmic Score: 0.17
  • Cytoplasmic Membrane Score: 9.51
  • Cellwall Score: 0.16
  • Extracellular Score: 0.15
  • Internal Helices: 0
• SignalP: Signal peptide LIPO(Sec/SPII) length 20 aa
  • SP(Sec/SPI): 0.006178
  • TAT(Tat/SPI): 0.000048
  • LIPO(Sec/SPII): 0.993611
  • Cleavage Site: CS pos: 20-21. LAA-CS. Pr: 0.9941
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_000727952 NCBI
• UniProt: see SPCG_0956

⊟Protein sequence

• MKKKLLAGAITLLSVATLAACSKGSEGADLISMKGDVITEHQFYEQVKSNPSAQQVLLNMTIQKVFEKQYGSELDDKEVDDTIAEEKKQYGENYQRVLSQAGMTLETRKAQIRTSKLVELAVKKVAEAELTDEAYKKAFDEYTPDVTAQIIRLNNEDKAKEVLEKAKAEGADFAQLAKDNSTDEKTKENGGEITFDSASTEVPEQVKKAAFALDVDGVSDVITATGTQAYSSQYYIVKLTKKTEKSSNIDDYKEKLKTVILTQKQNDSTFVQSIIGKELQAANIKVKDQAFQNIFTQYIGGGDSSSSSSTSNE

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

• MicrobesOnline: coiA > pepF > SPCG_RS04970 > prsA

⊟Regulation

• data available for D39, TIGR4

⊟Expression data

• PneumoExpress for strain D39V: SPV_0868 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications

K Overweg, A Kerr, M Sluijter, M H Jackson, T J Mitchell, A P de Jong, R de Groot, P W Hermans
The putative proteinase maturation protein A of Streptococcus pneumoniae is a conserved surface protein with potential to elicit protective immune responses.
Infect Immun: 2000, 68(7);4180-8
[PubMed:10858235] [WorldCat.org] [DOI] (P p)L E Cron, H J Bootsma, N Noske, P Burghout, S Hammerschmidt, P W M Hermans
Surface-associated lipoprotein PpmA of Streptococcus pneumoniae is involved in colonization in a strain-specific manner.
Microbiology (Reading): 2009, 155(Pt 7);2401-2410
[PubMed:19389773] [WorldCat.org] [DOI] (P p)