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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 02-MAY-2018

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae D39
  • locus tag: SPD_0868 [new locus tag: SPD_RS04670 ]
  • pan locus tag?: PNEUPAN002009000
  • symbol: SPD_0868
  • pan gene symbol?: prsA
  • synonym:
  • product: protease maturation protein, putative

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPD_0868 [new locus tag: SPD_RS04670 ]
  • symbol: SPD_0868
  • product: protease maturation protein, putative
  • replicon: chromosome
  • strand: +
  • coordinates: 882754..883695
  • length: 942
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    ATGAAGAAAAAATTATTGGCAGGTGCCATCACACTATTATCAGTAGCAACTTTAGCAGCT
    TGTTCGAAAGGGTCAGAAGGAGCAGACCTTATCAGCATGAAAGGGGATGTCATCACAGAA
    CATCAATTTTATGAGCAAGTGAAAAACAACCCTTCAGCCCAACAAGTCTTGTTAAATATG
    ACCATCCAAAAAGTTTTTGAAAAACAATATGGCTCAGAGCTTGATGATAAAGAGGTTGAT
    GATACTATTGCCGAAGAAAAAAAACAATATGGCGAAAACTACCAACGTGTCTTGTCACAA
    GCAGGTATGACTCTTGAAACACGTAAAGCTCAAATTCGTACAAGTAAATTAGTTGAGTTG
    GCAGTTAAGAAGGTAGCAGAAGCTGAATTGACAGATGAAGCCTATAAGAAAGCCTTTGAT
    GAGTACACTCCAGATGTAACGGCTCAAATCATCCGTCTTAATAATGAAGATAAGGCCAAA
    GAAGTTCTCGAAAAAGCCAAGGCAGAAGGTGCTGATTTTGCTCAATTAGCCAAAGATAAT
    TCAACTGATGAAAAAACAAAAGAAAATGGTGGAGAAATTACCTTTGATTCTGCTTCAACA
    GAAGTACCTGAGCAAGTCAAAAAAGCCGCTTTCGCTTTAGATGTGGATGGTGTTTCTGAT
    GTGATTACAGCAACTGGCACACAAGCCTACAGTAGCCAATATTACATTGTAAAACTCACT
    AAGAAAACAGAAAAATCATCTAATATTGATGACTACAAAGAAAAATTAAAAACTGTTATC
    TTGACTCAAAAACAAAATGATTCAACATTTGTTCAAAGCATTATCGGAAAAGAATTGCAA
    GCAGCCAATATCAAGGTTAAGGACCAAGCCTTCCAAAATATCTTTACCCAATATATCGGT
    GGTGGAGATTCAAGCTCAAGCAGTAGTACATCAAACGAATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    942

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPD_0868 [new locus tag: SPD_RS04670 ]
  • symbol: SPD_0868
  • description: protease maturation protein, putative
  • length: 313
  • theoretical pI: 4.74303
  • theoretical MW: 34439.3
  • GRAVY: -0.581789

⊟Function[edit | edit source]

  • TIGRFAM:
  • TheSEED  :
    • Putative parvulin type peptidyl-prolyl isomerase, similarity with PrsA foldase
    Protein Metabolism Protein folding Peptidyl-prolyl cis-trans isomerase  Putative parvulin type peptidyl-prolyl isomerase, similarity with PrsA foldase
  • PFAM:
    FKBP (CL0487) Rotamase_2; PPIC-type PPIASE domain (PF13145; HMM-score: 45.7)
    Rotamase; PPIC-type PPIASE domain (PF00639; HMM-score: 43.2)
    Rotamase_3; PPIC-type PPIASE domain (PF13616; HMM-score: 39.8)
    and 5 more
    no clan defined DUF4823; Domain of unknown function (DUF4823) (PF16105; HMM-score: 17.2)
    Trigger_C (CL0262) Trigger_C; Bacterial trigger factor protein (TF) C-terminus (PF05698; HMM-score: 16.7)
    SurA_N; SurA N-terminal domain (PF09312; HMM-score: 10.2)
    no clan defined DUF4473; Domain of unknown function (DUF4473) (PF14747; HMM-score: 8.9)
    Trigger_C (CL0262) SurA_N_3; SurA N-terminal domain (PF13624; HMM-score: 8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.17
    • Cytoplasmic Membrane Score: 9.51
    • Cellwall Score: 0.16
    • Extracellular Score: 0.15
    • Internal Helices: 0
  • SignalP: Signal peptide LIPO(Sec/SPII) length 20 aa
    • SP(Sec/SPI): 0.006396
    • TAT(Tat/SPI): 0.000048
    • LIPO(Sec/SPII): 0.993393
    • Cleavage Site: CS pos: 20-21. LAA-CS. Pr: 0.9939
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKKKLLAGAITLLSVATLAACSKGSEGADLISMKGDVITEHQFYEQVKNNPSAQQVLLNMTIQKVFEKQYGSELDDKEVDDTIAEEKKQYGENYQRVLSQAGMTLETRKAQIRTSKLVELAVKKVAEAELTDEAYKKAFDEYTPDVTAQIIRLNNEDKAKEVLEKAKAEGADFAQLAKDNSTDEKTKENGGEITFDSASTEVPEQVKKAAFALDVDGVSDVITATGTQAYSSQYYIVKLTKKTEKSSNIDDYKEKLKTVILTQKQNDSTFVQSIIGKELQAANIKVKDQAFQNIFTQYIGGGDSSSSSSTSNE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: ComX1 regulon
    ComX1(sigma factor)controls the expression of late competence genes [1]   other strains

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Jelle Slager, Rieza Aprianto, Jan-Willem Veening
    Refining the Pneumococcal Competence Regulon by RNA Sequencing.
    J Bacteriol: 2019, 201(13);
    [PubMed:30885934] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

K Overweg, A Kerr, M Sluijter, M H Jackson, T J Mitchell, A P de Jong, R de Groot, P W Hermans
The putative proteinase maturation protein A of Streptococcus pneumoniae is a conserved surface protein with potential to elicit protective immune responses.
Infect Immun: 2000, 68(7);4180-8
[PubMed:10858235] [WorldCat.org] [DOI] (P p)L E Cron, H J Bootsma, N Noske, P Burghout, S Hammerschmidt, P W M Hermans
Surface-associated lipoprotein PpmA of Streptococcus pneumoniae is involved in colonization in a strain-specific manner.
Microbiology (Reading): 2009, 155(Pt 7);2401-2410
[PubMed:19389773] [WorldCat.org] [DOI] (P p)

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