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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 02-MAY-2018

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae D39
  • locus tag: SPD_0316 [new locus tag: SPD_RS01720 ]
  • pan locus tag?: PNEUPAN001124000
  • symbol: cps2B
  • pan gene symbol?: cps2B
  • synonym: cps4B
  • product: tyrosine-protein phosphatase CpsB

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPD_0316 [new locus tag: SPD_RS01720 ]
  • symbol: cps2B
  • product: tyrosine-protein phosphatase CpsB
  • replicon: chromosome
  • strand: +
  • coordinates: 315192..315923
  • length: 732
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    ATGATAGACGTCCATTCGCATATCGTTTTTGATGTAGATGACGGTCCCAAGTCAAGAGAG
    GAAAGCAAGGCTCTCTTGGCAGAATCCTACAGGCAGGGGGTGCGAACCATTGTCTCTACC
    TCTCACCGTCGCAAGGGTATGTTTGAAACTCCGGAAGAGAAGATAGCAGAAAACTTTCTT
    CAGGTTCGGGAAATTGCAAAAGAAGTAGCAGATGATTTAGTCATTGCTTACGGGGCTGAA
    ATTTACTACACACCAGATGTTCTGGATAAGCTGGGAAAAAAGCGGATTCCGACCCTCAAT
    GATAGTCGTTATGCCTTGATAGAATTTAGTATGAACACTCCTTATCGCGATATTCATAGC
    GCCTTGAGCAAGATCTTGATGTCGGGAATTACTCCAGTCATTGCCCACATTGAGCGCTAT
    GATGCTCTTGGAAATAATGAAAAACGCGTTCGAGAACTGATTGATATGGGCTGTTACACG
    CAAGTAAATAGTTCACATGTCCTCAAACCAAAACTTTTTGGAGAACGTTATAAATTCATG
    AAAAAAAGAGCTCAGTATTTTTTAGAGCAGGATTTGGTTCATGTCATTGCAAGTGATATG
    CACAATCTAGACGGTAGACCTCCTCATATGGCAGAAGCATATGACCTTGTTACCCAAAAA
    TACGGAGAAGCGAAGGCTCAGGAACTTTTTATAGACAATCCTCGAAAAATTGTAATGGAT
    CAACTAATTTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    732

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPD_0316 [new locus tag: SPD_RS01720 ]
  • symbol: Cps2B
  • description: tyrosine-protein phosphatase CpsB
  • length: 243
  • theoretical pI: 6.80468
  • theoretical MW: 27974.9
  • GRAVY: -0.430041

⊟Function[edit | edit source]

  • reaction:
    EC 3.1.3.48?  ExPASy
    Protein-tyrosine-phosphatase Protein tyrosine phosphate + H2O = protein tyrosine + phosphate
  • TIGRFAM:
    histidinol phosphate phosphatase, HisJ family (TIGR01856; HMM-score: 12.3)
  • TheSEED  :
    • Tyrosine-protein phosphatase CpsB (EC 3.1.3.48)
    Cell Wall and Capsule Capsular and extracellular polysacchrides Extracellular Polysaccharide Biosynthesis of Streptococci  Tyrosine-protein phosphatase CpsB (EC 3.1.3.48)
  • PFAM:
    Amidohydrolase (CL0034) CpsB_CapC; Capsular polysaccharide synthesis, CpsB/CapC (PF19567; HMM-score: 235.9)
    and 2 more
    no clan defined DUF5748; Family of unknown function (DUF5748) (PF19022; HMM-score: 13.9)
    NADP_Rossmann (CL0063) ISPD_C; D-ribitol-5-phosphate cytidylyltransferase C-terminal domain (PF18706; HMM-score: 12.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9943
    • Cytoplasmic Membrane Score: 0.0033
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0024
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002441
    • TAT(Tat/SPI): 0.000512
    • LIPO(Sec/SPII): 0.000729
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MIDVHSHIVFDVDDGPKSREESKALLAESYRQGVRTIVSTSHRRKGMFETPEEKIAENFLQVREIAKEVADDLVIAYGAEIYYTPDVLDKLGKKRIPTLNDSRYALIEFSMNTPYRDIHSALSKILMSGITPVIAHIERYDALGNNEKRVRELIDMGCYTQVNSSHVLKPKLFGERYKFMKKRAQYFLEQDLVHVIASDMHNLDGRPPHMAEAYDLVTQKYGEAKAQELFIDNPRKIVMDQLI

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Judy K Morona, David C Miller, Renato Morona, James C Paton
The effect that mutations in the conserved capsular polysaccharide biosynthesis genes cpsA, cpsB, and cpsD have on virulence of Streptococcus pneumoniae.
J Infect Dis: 2004, 189(10);1905-13
[PubMed:15122528] [WorldCat.org] [DOI] (P p)

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