From PneumoWiki
Jump to navigation Jump to search
PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 02-MAY-2018

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae D39
  • locus tag: SPD_1407 [new locus tag: SPD_RS07480 ]
  • pan locus tag?: PNEUPAN002961000
  • symbol: apt
  • pan gene symbol?: apt
  • synonym:
  • product: adenine phosphoribosyltransferase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPD_1407 [new locus tag: SPD_RS07480 ]
  • symbol: apt
  • product: adenine phosphoribosyltransferase
  • replicon: chromosome
  • strand: -
  • coordinates: 1426254..1426784
  • length: 531
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    TTGAAAGAAAGAAAAAAGATGAATTTAAAAGATTACATTGCAACAATTGAAAATTATCCA
    AAGGAAGGCATTACCTTCCGTGATATTAGTCCTTTGATGGCTGATGGAAATGCTTATAGC
    TACGCTGTTCGTGAAATCGTTCAGTATGCTACTGACAAGAAAGTCGACATGATCGTGGGA
    CCTGAAGCTCGTGGATTTATCGTGGGTTGTCCAGTTGCCTTTGAGTTGGGAATTGGTTTT
    GCGCCTGTTCGTAAGCCAGGTAAATTGCCACGCGAAGTTATTTCTGCTGACTATGAAAAA
    GAGTACGGTGTCGATACCTTGACTATGCACGCGGATGCCATTAAGCCAGGTCAACGTGTT
    CTTATTGTAGATGACCTTTTGGCGACAGGTGGAACTGTTAAGGCAACTATCGAGATGATT
    GAAAAACTTGGTGGTGTTATGGCAGGTTGTGCCTTCCTTGTTGAATTGGATGAATTGAAC
    GGCCGTGAAAAAATTGGTGACTACGACTACAAAGTTCTTATGCATTATTAA
    60
    120
    180
    240
    300
    360
    420
    480
    531

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPD_1407 [new locus tag: SPD_RS07480 ]
  • symbol: Apt
  • description: adenine phosphoribosyltransferase
  • length: 176
  • theoretical pI: 5.09935
  • theoretical MW: 19529.6
  • GRAVY: -0.115909

⊟Function[edit | edit source]

  • reaction:
    EC 2.4.2.7?  ExPASy
    Adenine phosphoribosyltransferase AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate
  • TIGRFAM:
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides adenine phosphoribosyltransferase (TIGR01090; EC 2.4.2.7; HMM-score: 224.6)
    and 9 more
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis pur operon repressor PurR (TIGR01743; HMM-score: 47.3)
    Signal transduction Regulatory functions DNA interactions pur operon repressor PurR (TIGR01743; HMM-score: 47.3)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis orotate phosphoribosyltransferase (TIGR01367; EC 2.4.2.10; HMM-score: 40.5)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis orotate phosphoribosyltransferase (TIGR00336; EC 2.4.2.10; HMM-score: 36.1)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides xanthine phosphoribosyltransferase (TIGR01744; EC 2.4.2.22; HMM-score: 35.9)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis ribose-phosphate diphosphokinase (TIGR01251; EC 2.7.6.1; HMM-score: 19.8)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides uracil phosphoribosyltransferase (TIGR01091; EC 2.4.2.9; HMM-score: 18.7)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides hypoxanthine phosphoribosyltransferase (TIGR01203; EC 2.4.2.8; HMM-score: 18)
    Cellular processes Cellular processes DNA transformation comF family protein (TIGR00201; HMM-score: 14.3)
  • TheSEED  :
    • Adenine phosphoribosyltransferase (EC 2.4.2.7)
    Nucleosides and Nucleotides Purines Purine conversions  Adenine phosphoribosyltransferase (EC 2.4.2.7)
    and 2 more
    Regulation and Cell signaling Regulation and Cell signaling - no subcategory cAMP signaling in bacteria  Adenine phosphoribosyltransferase (EC 2.4.2.7)
    Regulation and Cell signaling Regulation and Cell signaling - no subcategory Stringent Response, (p)ppGpp metabolism  Adenine phosphoribosyltransferase (EC 2.4.2.7)
  • PFAM:
    PRTase-like (CL0533) Pribosyltran; Phosphoribosyl transferase domain (PF00156; HMM-score: 58.9)
    and 2 more
    UPRTase; Uracil phosphoribosyltransferase (PF14681; HMM-score: 18.2)
    PRTase_2; Phosphoribosyl transferase (PF15609; HMM-score: 12.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.02161
    • TAT(Tat/SPI): 0.000791
    • LIPO(Sec/SPII): 0.000954
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKERKKMNLKDYIATIENYPKEGITFRDISPLMADGNAYSYAVREIVQYATDKKVDMIVGPEARGFIVGCPVAFELGIGFAPVRKPGKLPREVISADYEKEYGVDTLTMHADAIKPGQRVLIVDDLLATGGTVKATIEMIEKLGGVMAGCAFLVELDELNGREKIGDYDYKVLMHY

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Retrieved from "http://pneumowiki.med.uni-greifswald.de/index.php?title=SPD_1407&oldid=7990"