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serotype 4
D39
serotype 2
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serotype 2
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serotype 19A
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670-6B
serotype 6B
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serotype 6A
70585
serotype 5
A026
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A66
serotype 3
AP200
serotype 11A
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serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 02-MAY-2018

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae D39
  • locus tag: SPD_1933 [new locus tag: SPD_RS10240 ]
  • pan locus tag?: PNEUPAN003715000
  • symbol: malQ
  • pan gene symbol?: malQ
  • synonym:
  • product: 4-alpha-glucanotransferase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPD_1933 [new locus tag: SPD_RS10240 ]
  • symbol: malQ
  • product: 4-alpha-glucanotransferase
  • replicon: chromosome
  • strand: -
  • coordinates: 1905553..1907070
  • length: 1518
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    ATGAAAAAACGTCAAAGTGGTGTGTTGATGCACATCTCTTCTCTTCCAGGAGCTTACGGA
    ATCGGATCATTTGGTCAAAGTGCTTACGACTTCGTTGATTTCTTGGTCCGTACAAAACAA
    CGTTACTGGCAAATCCTTCCATTAGGAGCAACTAGTTACGGGGATTCTCCTTACCAATCT
    TTCTCAGCCTTCGCAGGAAACACTCATTTTATCGATTTAGATATCTTGGTGGAGCAAGGT
    TTGTTGGAAGCAAGTGACCTTGAAGGAGTTGACTTTGGTAGCGATGCGTCTGAAGTTGAC
    TATGCTAAAATCTACTATGCACGTCGTCCTCTTTTAGAAAAAGCGGTGAAACGTTTCTTT
    GAAGTCGGAGATGTTAAAGATTTTGAGAAATTTGCTCAAGACAACCAATCATGGCTTGAG
    CTCTTTGCTGAGTATATGGCTATCAAAGAGTATTTTGACAATCTTGCTTGGACTGAATGG
    CCAGATGCAGATGCTCGTGCTCGTAAAGCTTCAGCACTTGAAAGCTATCGTGAGCAATTG
    GCAGACAAGTTGGTTTACCACCGTGTGACTCAATACTTCTTCTTCCAACAATGGTTGAAA
    TTGAAAGCTTACGCTAACGACAACCACATCGAAATCGTTGGGGACATGCCAATCTACGTA
    GCGGAAGATTCAAGTGATATGTGGGCAAATCCACATCTCTTCAAAACAGATGTCAATGGT
    AAGGCTACTTGTATCGCAGGATGCCCACCAGATGAGTTTTCTGTAACTGGTCAGCTTTGG
    GGTAACCCAATCTATGACTGGGAAGCAATGGACAAAGACGGCTACAAATGGTGGATTGAA
    CGCTTGCGTGAAAGCTTCAAAATCTACGATATCGTTCGTATCGACCACTTCCGTGGCTTC
    GAATCTTACTGGGAAATCCCTGCTGGTTCCGATACAGCAGCACCTGGTGAGTGGGTGAAA
    GGTCCAGGCTACAAGCTTTTTGCAGCCGTTAAGGAAGAACTTGGTGAGCTAAACATCATC
    GCAGAAGACCTTGGCTTCATGACAGATGAAGTGATCGAATTGCGTGAACGTACTGGCTTC
    CCAGGAATGAAGATTCTTCAATTTGCCTTCAACCCAGAAGACGAAAGCATTGATAGCCCA
    CACTTGGCACCTGCTAACTCAGTTATGTACACAGGAACACACGATAACAATACGGTTCTT
    GGTTGGTACCGTAATGAGATTGATGATGCGACTCGTGAGTACATGGCTCGTTACACGAAC
    CGTAAAGAATACGAAACAGTGGTACACGCTATGCTTCGTACAGTATTTTCATCAGTTAGC
    TTTATGGCAATTGCAACTATGCAAGATTTACTAGAATTGGATGAGGCAGCTCGTATGAAC
    TTCCCATCTACCCTTGGTGGAAACTGGTCTTGGCGTATGACTGAAGATCAATTGACACCA
    GCTGTCGAGGAAGGTTTGCTTGACTTGACAACAATTTATCGCCGAATTAATGAAAATTTG
    GTAGATTTAAAGAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1518

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPD_1933 [new locus tag: SPD_RS10240 ]
  • symbol: MalQ
  • description: 4-alpha-glucanotransferase
  • length: 505
  • theoretical pI: 4.43626
  • theoretical MW: 58075.9
  • GRAVY: -0.37901

⊟Function[edit | edit source]

  • reaction:
    EC 2.4.1.25?  ExPASy
    4-alpha-glucanotransferase Transfers a segment of a (1->4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1->4)-alpha-D-glucan
  • TIGRFAM:
    Metabolism Energy metabolism Biosynthesis and degradation of polysaccharides 4-alpha-glucanotransferase (TIGR00217; EC 2.4.1.25; HMM-score: 375.3)
  • TheSEED  :
    • 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25)
    Carbohydrates Di- and oligosaccharides Maltose and Maltodextrin Utilization  4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25)
    and 1 more
    Carbohydrates Polysaccharides Glycogen metabolism  4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25)
  • PFAM:
    Glyco_hydro_tim (CL0058) Glyco_hydro_77; 4-alpha-glucanotransferase (PF02446; HMM-score: 560.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 10
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helix: 1
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.180402
    • TAT(Tat/SPI): 0.019736
    • LIPO(Sec/SPII): 0.040356
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKKRQSGVLMHISSLPGAYGIGSFGQSAYDFVDFLVRTKQRYWQILPLGATSYGDSPYQSFSAFAGNTHFIDLDILVEQGLLEASDLEGVDFGSDASEVDYAKIYYARRPLLEKAVKRFFEVGDVKDFEKFAQDNQSWLELFAEYMAIKEYFDNLAWTEWPDADARARKASALESYREQLADKLVYHRVTQYFFFQQWLKLKAYANDNHIEIVGDMPIYVAEDSSDMWANPHLFKTDVNGKATCIAGCPPDEFSVTGQLWGNPIYDWEAMDKDGYKWWIERLRESFKIYDIVRIDHFRGFESYWEIPAGSDTAAPGEWVKGPGYKLFAAVKEELGELNIIAEDLGFMTDEVIELRERTGFPGMKILQFAFNPEDESIDSPHLAPANSVMYTGTHDNNTVLGWYRNEIDDATREYMARYTNRKEYETVVHAMLRTVFSSVSFMAIATMQDLLELDEAARMNFPSTLGGNWSWRMTEDQLTPAVEEGLLDLTTIYRRINENLVDLKK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulators: CcpA regulon, MalR (repression) regulon
    CcpA(TF)important in Global catabolite repression; RegPrecise 
    MalR(TF)important in Maltose utilization, Maltodextrin utilization; RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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