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serotype 4
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Hu17
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INV104
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INV200
serotype 14
JJA
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MDRSPN001
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NCTC7465
serotype 1
NCTC7466
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NU83127
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OXC141
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SP49
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SPN032672
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SPN034156
serotype 3
SPN034183
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SPN994038
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SPN994039
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SPNA45
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ST556
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TCH8431/19A
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Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 02-MAY-2018

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae D39
  • locus tag: SPD_2016 [new locus tag: SPD_RS10665 ]
  • pan locus tag?: PNEUPAN003885000
  • symbol: SPD_2016
  • pan gene symbol?: dusB
  • synonym:
  • product: TIM-barrel protein, nifR3 family protein, putative

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPD_2016 [new locus tag: SPD_RS10665 ]
  • symbol: SPD_2016
  • product: TIM-barrel protein, nifR3 family protein, putative
  • replicon: chromosome
  • strand: +
  • coordinates: 1993859..1994815
  • length: 957
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    ATGATTGGCAATATTGAGATTCCCAATCGTACCGTTTTAGCGCCTATGGCTGGCGTGACC
    AACTCAGCCTTTCGTACCATCGCAAAAGAGCTCGGAGCTGGACTCGTTGTAATGGAAATG
    GTCTCTGACAAGGGAATCCAATACAACAACGAAAAAACCCTGCATATGCTTCATATCGAT
    GAGGGCGAAAACCCTGTCTCTATCCAACTTTTTGGTAGCGATGAAGACAGCCTAGCACGC
    GCAGCAGAATTCATCCAAGAAAACACCAAGACCGATATCGTCGATATCAACATGGGCTGC
    CCTGTCAACAAAATCGTGAAGAACGAAGCTGGAGCTATGTGGCTCAAGGATCCTGACAAG
    ATCTACTCTATCATCAACAAGGTCCAGTCTGTCCTTGATATCCCACTTACTGTCAAAATG
    CGTACCGGCTGGGCGGACCCATCTCTGGCAGTAGAAAATGCCCTCGCTGCTGAGGCTGCA
    GGTGTTTCTGCCCTCGCCATGCATGGCCGTACCCGTGAACAAATGTATACTGGCCACGCA
    GACCTTGAGACCCTTTACAAGGTTGCCCAAGCTCTAACCAAGATTCCATTCATCGCCAAC
    GGTGATATCCGTACTGTCCAAGAAGCCAAGCAACGCATCGAAGAAGTTGGTGCTGACGCA
    GTCATGATTGGCCGAGCTGCCATGGGAAATCCTTACCTCTTCAACCAAATCAACCATTAC
    TTTGAAACAGGAGAAATCCTACCTGATTTGACCTTTGAAGACAAGATGAAGATCGCCTAC
    GAACACTTGAAACGATTGATTAACCTCAAAGGAGAAAACGTCGCAGTTCGTGAATTCCGC
    GGCCTCGCTCCTCACTATCTCCGTGGAACATCTGGCGCTGCCAAACTCCGTGGAGCCATT
    TCGCAAGCTAGCACCCTAGCAGAGATTGAAGCCCTCTTGCAATTGGAGAAGGCTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    957

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPD_2016 [new locus tag: SPD_RS10665 ]
  • symbol: SPD_2016
  • description: TIM-barrel protein, nifR3 family protein, putative
  • length: 318
  • theoretical pI: 5.44182
  • theoretical MW: 34861.9
  • GRAVY: -0.112579

⊟Function[edit | edit source]

  • TIGRFAM:
    Unknown function General putative TIM-barrel protein, nifR3 family (TIGR00737; HMM-score: 361)
    and 10 more
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA dihydrouridine synthase A (TIGR00742; EC 1.-.-.-; HMM-score: 105.2)
    dihydroorotate dehydrogenase family protein (TIGR01037; EC 1.3.-.-; HMM-score: 52.2)
    Unknown function General putative TIM-barrel protein (TIGR00736; HMM-score: 36.2)
    Metabolism Amino acid biosynthesis Histidine family imidazoleglycerol phosphate synthase, cyclase subunit (TIGR00735; HMM-score: 23.7)
    glycosyl amidation-associated protein WbuZ (TIGR03572; HMM-score: 23.2)
    Metabolism Energy metabolism Other L-lactate oxidase (TIGR02708; EC 1.1.3.-; HMM-score: 18.7)
    Metabolism Amino acid biosynthesis Histidine family 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase (TIGR00007; EC 5.3.1.16; HMM-score: 16.7)
    heme/flavin dehydrogenase, mycofactocin system (TIGR03966; EC 1.-.-.-; HMM-score: 14.9)
    mycofactocin system FadH/OYE family oxidoreductase 2 (TIGR03997; EC 1.-.-.-; HMM-score: 14.4)
    geranylgeranylglyceryl phosphate synthase family protein (TIGR01768; EC 2.5.1.-; HMM-score: 13.1)
  • TheSEED  :
    • tRNA-dihydrouridine synthase DusB
    RNA Metabolism RNA processing and modification tRNA modification Archaea  tRNA dihydrouridine synthase B (EC 1.-.-.-)
  • PFAM:
    TIM_barrel (CL0036) Dus; Dihydrouridine synthase (Dus) (PF01207; HMM-score: 303.8)
    and 5 more
    FMN_dh; FMN-dependent dehydrogenase (PF01070; HMM-score: 21.5)
    His_biosynth; Histidine biosynthesis protein (PF00977; HMM-score: 20.9)
    Oxidored_FMN; NADH:flavin oxidoreductase / NADH oxidase family (PF00724; HMM-score: 19.3)
    PK_TIM (CL0151) PEP_mutase; Phosphoenolpyruvate phosphomutase (PF13714; HMM-score: 16.9)
    TIM_barrel (CL0036) IMPDH; IMP dehydrogenase / GMP reductase domain (PF00478; HMM-score: 16.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9945
    • Cytoplasmic Membrane Score: 0.0002
    • Cell wall & surface Score: 0.0003
    • Extracellular Score: 0.005
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.01702
    • TAT(Tat/SPI): 0.002868
    • LIPO(Sec/SPII): 0.001733
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MIGNIEIPNRTVLAPMAGVTNSAFRTIAKELGAGLVVMEMVSDKGIQYNNEKTLHMLHIDEGENPVSIQLFGSDEDSLARAAEFIQENTKTDIVDINMGCPVNKIVKNEAGAMWLKDPDKIYSIINKVQSVLDIPLTVKMRTGWADPSLAVENALAAEAAGVSALAMHGRTREQMYTGHADLETLYKVAQALTKIPFIANGDIRTVQEAKQRIEEVGADAVMIGRAAMGNPYLFNQINHYFETGEILPDLTFEDKMKIAYEHLKRLINLKGENVAVREFRGLAPHYLRGTSGAAKLRGAISQASTLAEIEALLQLEKA

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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