PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 02-FEB-2021

⊟Summary

• organism: Streptococcus pneumoniae D39
• locus tag: SPD_RS07130 [old locus tag: SPD_1339 ]
• pan locus tag^?: PNEUPAN002836000
• symbol: atpF
• pan gene symbol^?: atpF
• synonym:
• product: F0F1 ATP synthase subunit B

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPD_RS07130 [old locus tag: SPD_1339 ]
• symbol: atpF
• product: F0F1 ATP synthase subunit B
• replicon: chromosome
• strand: -
• coordinates: 1354369..1354863
• length: 495
• essential: unknown other strains

⊟Accession numbers

• Location: NC_008533 (1354369..1354863) NCBI
• BioCyc: G1G6V-1461 BioCyc
• MicrobesOnline: see SPD_1339
• PneumoBrowse for strain D39V: SPV_1339 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
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  481
  
  ATGCACGTAACAGTAGGTGAATTAATTGGTAATTTTATTTTAATCACTGGCTCTTTTATT
  CTTTTGCTAGTCTTGATTAAAAAATTTGCATGGTCTAATATTACAGGCATTTTCGAAGAA
  AGAGCTGAAAAAATTGCTTCAGATATTGACAGAGCTGAAGAAGCCCGTCAAAAAGCAGAA
  GTATTGGCTCAAAAACGCGAAGATGAATTGGCTGGTAGCCGTAAAGAAGCTAAGACAATC
  ATTGAAAATGCAAAGGAAACAGCTGAGCAAAGTAAGGCTAATATCTTAGCAGATGCTAAA
  CTAGAAGCAGGACACTTAAAAGAAAAAGCCAATCAAGAAATTGCTCAAAATAAAGTAGAA
  GCTTTACAGAGTGTTAAGGGTGAGGTCGCAGATTTGACCATCAGCTTAGCTGGTAAAATC
  ATCTCACAAAACCTTGACAGTCATGCCCATAAAGCACTCATTGATCAGTATATCGATCAG
  CTAGGAGAAGCTTAA
  60
  120
  180
  240
  300
  360
  420
  480
  495
  

⊟Protein

⊟General

• locus tag: SPD_RS07130 [old locus tag: SPD_1339 ]
• symbol: AtpF
• description: F0F1 ATP synthase subunit B
• length: 164
• theoretical pI: 5.11586
• theoretical MW: 17986.4
• GRAVY: -0.218902

⊟Function

• reaction:
  EC 7.1.2.2?  ExPASy
  non-specified enzyme name
• TIGRFAM:
  Metabolism Energy metabolism ATP-proton motive force interconversion ATP synthase F0, B subunit (TIGR01144; EC 3.6.3.14; HMM-score: 133.3)
  and 6 more
  alternate F1F0 ATPase, F0 subunit B (TIGR03321; EC 3.6.3.-; HMM-score: 57)
  Genetic information processing Transcription Degradation of RNA ribonuclease Y (TIGR03319; EC 3.1.-.-; HMM-score: 15)
  Cellular processes Cellular processes Pathogenesis protein TolA (TIGR02794; HMM-score: 10.7)
  Metabolism Transport and binding proteins Other protein TolA (TIGR02794; HMM-score: 10.7)
  flagellar assembly protein FliH (TIGR03825; HMM-score: 9.7)
  ATP synthase archaeal, H subunit (TIGR02926; EC 3.6.3.14; HMM-score: 9.5)
• TheSEED: see SPD_1339
• PFAM:
  ATP_synthase (CL0255) ATP-synt_B; ATP synthase B/B' CF(0) (PF00430; HMM-score: 94)
  and 7 more
  no clan defined RNase_Y_N; RNase Y N-terminal region (PF12072; HMM-score: 17.5)
  OmpH; Outer membrane protein (OmpH-like) (PF03938; HMM-score: 16.1)
  DUF2018; Domain of unknown function (DUF2018) (PF09442; HMM-score: 15)
  ATP_synthase (CL0255) Mt_ATP-synt_B; Mitochondrial ATP synthase B chain precursor (ATP-synt_B) (PF05405; HMM-score: 10.6)
  no clan defined MAT1; CDK-activating kinase assembly factor MAT1 (PF06391; HMM-score: 10.4)
  DUF4570; Domain of unknown function (DUF4570) (PF15134; HMM-score: 9.2)
  DivIVA; DivIVA protein (PF05103; HMM-score: 7.7)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic Membrane
  • Cytoplasmic Score: 1.05
  • Cytoplasmic Membrane Score: 8.78
  • Cellwall Score: 0.08
  • Extracellular Score: 0.09
  • Internal Helix: 1
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.067917
  • TAT(Tat/SPI): 0.001356
  • LIPO(Sec/SPII): 0.003767
• predicted transmembrane helices (TMHMM): 1

⊟Accession numbers

• GI:
• RefSeq: WP_000558554 NCBI
• UniProt: see SPD_1339

⊟Protein sequence

• MHVTVGELIGNFILITGSFILLLVLIKKFAWSNITGIFEERAEKIASDIDRAEEARQKAEVLAQKREDELAGSRKEAKTIIENAKETAEQSKANILADAKLEAGHLKEKANQEIAQNKVEALQSVKGEVADLTISLAGKIISQNLDSHAHKALIDQYIDQLGEA

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

• MicrobesOnline: SPD_RS07105 < atpD < SPD_RS07115 < SPD_RS07120 < SPD_RS07125 < atpF < atpB < SPD_RS07140 < SPD_RS07145

⊟Regulation

• data available for TIGR4

⊟Expression data

• PneumoExpress for strain D39V: SPV_1339 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications