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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 24-APR-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae G54
  • locus tag: SPG_RS10795 [old locus tag: SPG_2163 ]
  • pan locus tag?: PNEUPAN003923000
  • symbol: mreD
  • pan gene symbol?: mreD
  • synonym:
  • product: rod shape-determining protein MreD

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPG_RS10795 [old locus tag: SPG_2163 ]
  • symbol: mreD
  • product: rod shape-determining protein MreD
  • replicon: chromosome
  • strand: -
  • coordinates: 2054649..2055143
  • length: 495
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_011072 (2054649..2055143) NCBI
  • BioCyc: SPG_RS10795 BioCyc
  • MicrobesOnline: see SPG_2163
  • PneumoBrowse for strain D39V: SPV_2044 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    ATGAGACAGTTGAAGCGAGTTGGAGTATTTTTATTGCTTCCTTTCTTTGTTCTAATTGAC
    GCCCATATTAGCCAGCTTCTGGGCTCATTTTTCCCCCATGTACATTTGGCTAGTCATTTT
    CTTTTTCTATTTCTCTTATTTGAGACGATAGAAGTATCAGAGTATCTCTACCTAGTCTAT
    TGTTTTGTTATAGGCTTGGTTTATGATGTTTACTTTTTCCATCTAATAGGGATTACAACT
    CTCTTATTTATCTTATTGGGAGCCTTCCTTCATAAATTGAATAGTGTTATTTTGTTGAAT
    CGTTGGACAAGAATGCTAGCTATGATTGTGCTGACATTCCTGTTTGAAATGGGTAGTTAT
    CTTTTGGCTTTTATGGTAGGGTTGACAGTAGATAGCATGTCGATTTTTATAGTCTATAGC
    TTGGTACCGACGATGATTTTAAATTTTTTATGGATTACTGTTTTTCAATTTATTTTTGAA
    AAATATTATCTATAA
    60
    120
    180
    240
    300
    360
    420
    480
    495

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPG_RS10795 [old locus tag: SPG_2163 ]
  • symbol: MreD
  • description: rod shape-determining protein MreD
  • length: 164
  • theoretical pI: 7.15708
  • theoretical MW: 19324.3
  • GRAVY: 1.30488

⊟Function[edit | edit source]

  • TIGRFAM:
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan rod shape-determining protein MreD (TIGR03426; HMM-score: 71.8)
    and 2 more
    Genetic information processing Mobile and extrachromosomal element functions Prophage functions toxin secretion/phage lysis holin (TIGR01593; HMM-score: 10.3)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking toxin secretion/phage lysis holin (TIGR01593; HMM-score: 10.3)
  • TheSEED: see SPG_2163
  • PFAM:
    Gx_transp (CL0315) MreD; rod shape-determining protein MreD (PF04093; HMM-score: 134)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 5
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0001
    • Cytoplasmic Membrane Score: 0.9998
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0001
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.034465
    • TAT(Tat/SPI): 0.000381
    • LIPO(Sec/SPII): 0.063933
  • predicted transmembrane helices (TMHMM): 5

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001249454 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MRQLKRVGVFLLLPFFVLIDAHISQLLGSFFPHVHLASHFLFLFLLFETIEVSEYLYLVYCFVIGLVYDVYFFHLIGITTLLFILLGAFLHKLNSVILLNRWTRMLAMIVLTFLFEMGSYLLAFMVGLTVDSMSIFIVYSLVPTMILNFLWITVFQFIFEKYYL

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Adrian D Land, Malcolm E Winkler
The requirement for pneumococcal MreC and MreD is relieved by inactivation of the gene encoding PBP1a.
J Bacteriol: 2011, 193(16);4166-79
[PubMed:21685290] [WorldCat.org] [DOI] (I p)

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