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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_0856 [new locus tag: SPH_RS04130 ]
  • pan locus tag?: PNEUPAN001696000
  • symbol: prfB
  • pan gene symbol?: prfB
  • synonym:
  • product: peptide chain release factor 2

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_0856 [new locus tag: SPH_RS04130 ]
  • symbol: prfB
  • product: peptide chain release factor 2
  • replicon: chromosome
  • strand: +
  • coordinates: 792577..793566
  • length: 990
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    TTGGAAAACAAGATGACAGAACCTGATTTTTGGAACGATAATATTGCGGCCCAAAAAACG
    TCGCAAGAATTAAATGAATTAAAAAACACTTACAATACCTTCCATAAGATGGAAGAGTTG
    CAGGATGAAGTCGAAATTTTATTGGATTTTTTGGCTGAAGACGAGTCAGTGCATGATGAA
    CTGGTAGCGCAGTTAGCCGAACTTGATAAGATAATGACCAGCTACGAGATGACTCTACTC
    TTGTCAGAACCTTATGACCACAACAATGCCATCTTGGAAATCCATCCAGGTTCTGGTGGT
    ACTGAGGCGCAGGACTGGGGTGATATGTTGCTTCGTATGTATACTCGTTATGGTAATGCT
    AAAGGCTTTAAAGTGGAAGTGTTGGATTACCAAGCAGGTGATGAGGCTGGTATTAAGTCG
    GTAACTTTATCATTTGAAGGGCCTAATGCCTATGGTCTCCTCAAGTCAGAAATGGGTGTT
    CACCGCTTAGTGCGAATCTCACCATTTGACTCTGCCAAACGTCGCCATACCTCTTTCACA
    TCTGTAGAAGTGATGCCAGAATTGGATGATACTATTGAAGTGGAAATCCGTGAAGATGAT
    ATCAAGATGGATACCTTCCGTTCAGGTGGTGCCGGTGGACAAAACGTCAATAAGGTTTCA
    ACAGGTGTACGTTTAACCCACATTCCAACTGGAATTGTTGTCCAATCAACAGTGGATCGT
    ACCCAGTATGGAAATAGAGATCGTGCCATGAAGATGTTGCAGGCTAAGCTCTATCAAATG
    GAGCAAGAGAAGAAGGCTGCGGAGGTAGATTCTCTCAAAGGTGAGAAAAAGGAGATTACT
    TGGGGAAGTCAAATCCGTTCTTATGTCTTCACGCCTTATACTATGGTAAAAGATCACCGA
    ACTAGCTTTGAGGTTGCTCAGGTAGATAAGGTTATGGATGGGGACCTAGATGGTTTTATC
    GATGCTTATCTCAAGTGGCGAATTAGCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    990

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_0856 [new locus tag: SPH_RS04130 ]
  • symbol: PrfB
  • description: peptide chain release factor 2
  • length: 329
  • theoretical pI: 4.55295
  • theoretical MW: 37448.9
  • GRAVY: -0.558967

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Protein synthesis Translation factors peptide chain release factor 2 (TIGR00020; HMM-score: 480.8)
    and 2 more
    Genetic information processing Protein synthesis Translation factors peptide chain release factor 1 (TIGR00019; HMM-score: 270.1)
    Genetic information processing Protein synthesis Translation factors putative peptide chain release factor H (TIGR03072; HMM-score: 104.6)
  • TheSEED  :
    • Peptide chain release factor 2
    • programmed frameshift-containing
    Protein Metabolism Protein biosynthesis Programmed frameshift  Peptide chain release factor 2
    and 2 more
    Protein Metabolism Protein biosynthesis Programmed frameshift  programmed frameshift-containing
    Protein Metabolism Protein biosynthesis Translation termination factors bacterial  Peptide chain release factor 2
  • PFAM:
    no clan defined PCRF; PCRF domain (PF03462; HMM-score: 197.4)
    and 3 more
    RF (CL0337) RF-1; RF-1 domain (PF00472; HMM-score: 135.4)
    GST_C (CL0497) Tom37_C; Tom37 C-terminal domain (PF11801; HMM-score: 10.5)
    no clan defined ABC_tran_CTD; ABC transporter C-terminal domain (PF16326; HMM-score: 7.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9883
    • Cytoplasmic Membrane Score: 0.0005
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0111
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002615
    • TAT(Tat/SPI): 0.00015
    • LIPO(Sec/SPII): 0.000386
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MENKMTEPDFWNDNIAAQKTSQELNELKNTYNTFHKMEELQDEVEILLDFLAEDESVHDELVAQLAELDKIMTSYEMTLLLSEPYDHNNAILEIHPGSGGTEAQDWGDMLLRMYTRYGNAKGFKVEVLDYQAGDEAGIKSVTLSFEGPNAYGLLKSEMGVHRLVRISPFDSAKRRHTSFTSVEVMPELDDTIEVEIREDDIKMDTFRSGGAGGQNVNKVSTGVRLTHIPTGIVVQSTVDRTQYGNRDRAMKMLQAKLYQMEQEKKAAEVDSLKGEKKEITWGSQIRSYVFTPYTMVKDHRTSFEVAQVDKVMDGDLDGFIDAYLKWRIS

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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