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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 24-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_RS02260 [old locus tag: SPH_0465 ]
  • pan locus tag?: PNEUPAN000101000
  • symbol: wecB
  • pan gene symbol?: cps4I
  • synonym:
  • product: non-hydrolyzing UDP-N-acetylglucosamine 2-epimerase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_RS02260 [old locus tag: SPH_0465 ]
  • symbol: wecB
  • product: non-hydrolyzing UDP-N-acetylglucosamine 2-epimerase
  • replicon: chromosome
  • strand: +
  • coordinates: 415157..416245
  • length: 1089
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_010380 (415157..416245) NCBI
  • BioCyc: SPH_RS02260 BioCyc
  • MicrobesOnline: see SPH_0465
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    ATGAAAAAAATTATGTTAGTATTCGGTACACGTCCGGAAGCCATCAAAATGTGTCCATTA
    GTCAATGAGTTGAAAAAACACGAAGATATGGAAACAATTGTGTGTGTTACTGGACAACAC
    AAAGAGATGGTTAGTCCTGTTTTAGATTTATTTGGTGTTGTACCAGATTATGATTTAGAA
    ATTATGAAGGCTAACCAAACCTTGTTCTCTATCACAACTAGTATCTTGGAAAAGATAAAA
    CCAGTTTTAGAGAAGGAACAACCAGATATTGTCCTAGTTCACGGTGACACTACGACAACT
    TATGCAGCAGCCTTGGCAGCATTCTATTTGGGAATTAAAGTAGGACATGTTGAAGCTGGT
    TTGCGAACGTACAATTTACAAAGTCCATTTCCTGAAGAATTTAACAGGCAATCGACATCA
    ATCATTGCAACTTACCATTTTGCTCCAACTGAGTTGGCTAAAGAAAATCTCTTAAAAGAA
    GGTAGAGAGAATGTTTATGTGACTGGAAATACTGTCATTGATGCTCTTACAACTACTGTT
    CAAGAGGATTATACACACACTCATTTAGATTTAAACGCTAACAATCGTCTCATCTTATTG
    ACTGCTCATAGACGCGAAAATCTCGGCGAACCGATGAGACATATGTTTAGAGCAGTTAAA
    CGAGTATTGAATGAATACGAAGATGTTAAAGTCATTTATCCAATTCATAAGAATCCTTTG
    GTACGTGAAACAGCTGCAGAGATCTTTGGAGATACAGAACGGATTCAAATTATTGAACCT
    TTGGATGTTCTTGATTTCCACAACTTCATGAACCAAAGTTATATGATTTTAACAGATTCT
    GGCGGAGTTCAGGAAGAAGCACCTTCTTTAGGAAAACCTGTATTGGTTATGCGCGATACT
    ACTGAAAGACCTGAAGGAGTAGCGGCAGGAACCTTGAAATTAGTAGGAACTGACGAAGAA
    ACAATTTATCAAAACTTCAAACTACTTCTAGATGATTCTGGAGAATACAAAAAAATGAGT
    CAGGCTAGCAATCCATACGGTAATGGTGATGCTAGTCAACAGATTGTTCAGATTTTGCGT
    GGGATTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1089

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_RS02260 [old locus tag: SPH_0465 ]
  • symbol: WecB
  • description: non-hydrolyzing UDP-N-acetylglucosamine 2-epimerase
  • length: 362
  • theoretical pI: 5.06379
  • theoretical MW: 40750.4
  • GRAVY: -0.241989

⊟Function[edit | edit source]

  • reaction:
    EC 5.1.3.14?  ExPASy
    UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-mannosamine
  • TIGRFAM:
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides UDP-N-acetylglucosamine 2-epimerase (TIGR00236; EC 5.1.3.14; HMM-score: 522)
    and 4 more
    UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing (TIGR03568; EC 3.1.4.-,5.1.3.-; HMM-score: 114.6)
    conserved hypothetical protein (TIGR03492; HMM-score: 24.2)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA-guanine transglycosylase (TIGR00430; EC 2.4.2.29; HMM-score: 12.7)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA-guanine family transglycosylase (TIGR00449; EC 2.4.2.-; HMM-score: 12.5)
  • TheSEED: see SPH_0465
  • PFAM:
    GT-B (CL0113) Epimerase_2; UDP-N-acetylglucosamine 2-epimerase (PF02350; HMM-score: 402.5)
    and 4 more
    Glyco_trans_4_2; Glycosyl transferase 4-like (PF13477; HMM-score: 19.8)
    Glyco_transf_4; Glycosyltransferase Family 4 (PF13439; HMM-score: 18.3)
    MGDG_synth; Monogalactosyldiacylglycerol (MGDG) synthase (PF06925; HMM-score: 14)
    PKinase (CL0016) Fructosamin_kin; Fructosamine kinase (PF03881; HMM-score: 12.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9985
    • Cytoplasmic Membrane Score: 0.0008
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.0006
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.006447
    • TAT(Tat/SPI): 0.000069
    • LIPO(Sec/SPII): 0.001078
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKKIMLVFGTRPEAIKMCPLVNELKKHEDMETIVCVTGQHKEMVSPVLDLFGVVPDYDLEIMKANQTLFSITTSILEKIKPVLEKEQPDIVLVHGDTTTTYAAALAAFYLGIKVGHVEAGLRTYNLQSPFPEEFNRQSTSIIATYHFAPTELAKENLLKEGRENVYVTGNTVIDALTTTVQEDYTHTHLDLNANNRLILLTAHRRENLGEPMRHMFRAVKRVLNEYEDVKVIYPIHKNPLVRETAAEIFGDTERIQIIEPLDVLDFHNFMNQSYMILTDSGGVQEEAPSLGKPVLVMRDTTERPEGVAAGTLKLVGTDEETIYQNFKLLLDDSGEYKKMSQASNPYGNGDASQQIVQILRGI

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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