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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 24-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_RS06260 [old locus tag: SPH_1293 ]
  • pan locus tag?: PNEUPAN002414000
  • symbol: dhaS
  • pan gene symbol?: dhaS
  • synonym:
  • product: dihydroxyacetone kinase transcriptional activator DhaS

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_RS06260 [old locus tag: SPH_1293 ]
  • symbol: dhaS
  • product: dihydroxyacetone kinase transcriptional activator DhaS
  • replicon: chromosome
  • strand: +
  • coordinates: 1199798..1200328
  • length: 531
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_010380 (1199798..1200328) NCBI
  • BioCyc: SPH_RS06260 BioCyc
  • MicrobesOnline: see SPH_1293
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    ATGGCATCATCACTCATTACAAAAAAACGGATTGCCAAGGCATTTAGAGACCTATTAGCT
    ACTAGAGAATTTGACAAAATCTCCATTGTAGATATTATGGAATCAGCTGGCATTCGTAGA
    CAGACCTTTTATAATCACTTTCTTGACAAATATGAACTGCTAGACTGGATATTTGAAAAT
    GACTTAACCGAGTATATCACCAATAACTTGGACTTCATTTCGGGCCAAAAACTATTACAA
    GAATTATTTTTTTATTTCGAACAAGAGCGTGACTTTTATATTCAACTTTTTGATATTCAA
    GGGCAAAATAACTTCTATGACCACTTTATCAGCTACTGTCGCTTGCTTGTATCAAAAATT
    TTAAGAGAATACGGTCAGATTGATATCGATTCATCTGCTTATACTTGCTTTTTGTTAGAC
    TATCATTCACATGCTCTAGCAGAAATCGTGAAGGCTTATGTCAATAAAAAAAGTTCAGTT
    CCACAACCAGACTTTCTCATCATGACAATTATTGGAAAGAGACCACAATGA
    60
    120
    180
    240
    300
    360
    420
    480
    531

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_RS06260 [old locus tag: SPH_1293 ]
  • symbol: DhaS
  • description: dihydroxyacetone kinase transcriptional activator DhaS
  • length: 176
  • theoretical pI: 5.6628
  • theoretical MW: 20917.8
  • GRAVY: -0.1625

⊟Function[edit | edit source]

  • TIGRFAM:
    probable dihydroxyacetone kinase regulator (TIGR02366; HMM-score: 187.9)
    and 1 more
    Signal transduction Regulatory functions DNA interactions mycofactocin system transcriptional regulator (TIGR03968; HMM-score: 27.1)
  • TheSEED: see SPH_1293
  • PFAM:
    TetR_C (CL0174) TetR_C_8; Transcriptional regulator C-terminal region (PF14278; HMM-score: 32)
    HTH (CL0123) TetR_N; Bacterial regulatory proteins, tetR family (PF00440; HMM-score: 28.5)
    and 3 more
    HTH_Tnp_1_2; Helix-turn-helix of insertion element transposase (PF13022; HMM-score: 19.6)
    no clan defined CRISPR_Cas2; CRISPR associated protein Cas2 (PF09827; HMM-score: 14.3)
    RRM (CL0221) YlmH_RBD; Putative RNA-binding domain in YlmH (PF17774; HMM-score: 13.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9193
    • Cytoplasmic Membrane Score: 0.0636
    • Cell wall & surface Score: 0.0008
    • Extracellular Score: 0.0162
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.000663
    • TAT(Tat/SPI): 0.000139
    • LIPO(Sec/SPII): 0.000196
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MASSLITKKRIAKAFRDLLATREFDKISIVDIMESAGIRRQTFYNHFLDKYELLDWIFENDLTEYITNNLDFISGQKLLQELFFYFEQERDFYIQLFDIQGQNNFYDHFISYCRLLVSKILREYGQIDIDSSAYTCFLLDYHSHALAEIVKAYVNKKSSVPQPDFLIMTIIGKRPQ

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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