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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 24-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_RS09110 [old locus tag: SPH_1869 ]
  • pan locus tag?: PNEUPAN003188000
  • symbol: gtfA
  • pan gene symbol?: gtfA
  • synonym:
  • product: accessory Sec system glycosyltransferase GtfA

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_RS09110 [old locus tag: SPH_1869 ]
  • symbol: gtfA
  • product: accessory Sec system glycosyltransferase GtfA
  • replicon: chromosome
  • strand: -
  • coordinates: 1725268..1726779
  • length: 1512
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_010380 (1725268..1726779) NCBI
  • BioCyc: SPH_RS09110 BioCyc
  • MicrobesOnline: see SPH_1869
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    ATGACAATTTACAATATAAATTTAGGAATTGGTTGGGCTAGTAGCGGTGTTGAATACGCT
    CAAGCCTATCGTGCTGGTGTTTTTCGGAAATTAAATCTGTCCTCTAAGTTTATCTTTACA
    GATATGATTTTAGCCGATAATATTCAGCACTTAACAGCCAATATTGGTTTTGATGATAAT
    CAGGTTATCTGGCTTTATAATCATTTCACAGATATCAAAATTGCGCCTACTAGCGTGACA
    GTGGATGATGTCTTGGCTTACTTTGGTGGTGAAGAAAGTCACAGAGAAAAAAATGGCAAG
    GTTTTACGTGTCTTCTTTTTTGACCAAGATAAGTTTGTAACCTGTTATTTAGTTGATGAG
    AACAAGGACTTGGTTCAACATGCCGAGTATGTTTTTAAGGGAAACCTGATTCGGAAGGAT
    TACTTTTCTTATACGCGTTATTGTAGCGAGTATTTTGCTCCCAAGGACAATGTTGCAGTC
    TTATACCAACGAACTTTTTACAATGAAGACGGGACTCCAGTCTATGATATTTTGATGAAT
    CAAGGGAAGGAAGAAGTTTATCATTTCAAGGATAAGATTTTCTATGGAAAGCAAGCTTTT
    GTGCGTGCCTTTATGAAATCTTTGAATTTGAATAAGTCTGATTTGGTCATTCTCGATAGG
    GAGACAGGCATTGGTCAGGTTGTGTTTGAGGAAGCACAGACAGCACATTTAGCGGTAGTT
    GTTCATGCGGAGCATTATAGTGAAAATGCTACAAATGAGGACTACATCCTTTGGAATAAC
    TATTATGACTATCAGTTTACCAATGCAGATAAGGTTGACTTCTTTATCGTGTCTACTGAT
    AGACAAAATGAAGTTCTACAAGAGCAATTTGCCAAATATACTCAGCATCAGCCAAAGATT
    GTTACCATTCCTGTAGGCAGTATTGATTCCTTGACAGATTCAAGTCAGGGACGTAAGCCA
    TTTTCTTTAATTACCGCTTCACGTCTTGCCAAAGAAAAGCACATTGATTGGCTTGTGAAA
    GCTGTGATTGAAGCTCATAAGGAGTTACCGGAACTAACCTTTGATATCTATGGTAGTGGT
    GGAGAAGATTCTCTGCTTAGAGAAATTATTGCAAATCATCAGGCAGAGGACTATATCCAA
    CTCAAGGGGCATGCGGAACTTTCGCAGATTTATAGCCAGTATGAGGTCTACTTAACGGCT
    TCTACCAGCGAAGGATTTGGTCTGACCTTGATGGAAGCTATTGGTTCAGGTCTACCTCTA
    ATTGGTTTTGATGTGCCTTATGGTAATCAGACCTTTATAGAGGATGGGCAAAATGGTTAT
    TTGATTCCAAGTTCATCTGACCATGTAGAAGACCAAATCAAGCAAGCTTATGCCGCTAAG
    ATTTGTCAATTGTATCAAGAAAATCGTTTGGAAGCTATGCGTGCCTATTCTTATCAAATT
    GCAGAAGGCTTCTTGACCAAAGAAATTTTAGAAAAGTGGAAGAAAACAGTAGAGGAGGTG
    CTCCATGATTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1512

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_RS09110 [old locus tag: SPH_1869 ]
  • symbol: GtfA
  • description: accessory Sec system glycosyltransferase GtfA
  • length: 503
  • theoretical pI: 4.74829
  • theoretical MW: 57781.4
  • GRAVY: -0.322863

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Protein fate Protein modification and repair accessory Sec system glycosylation protein GtfA (TIGR02918; EC 2.4.1.-; HMM-score: 846.8)
    and 11 more
    sugar transferase, PEP-CTERM/EpsH1 system associated (TIGR03088; HMM-score: 52.5)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Glutathione and analogs N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA (TIGR03999; EC 2.4.1.-; HMM-score: 46.1)
    glycosyltransferase, GG-Bacteroidales peptide system (TIGR04157; EC 2.4.1.-; HMM-score: 32.1)
    Unknown function Enzymes of unknown specificity glycosyltransferase, MSMEG_0565 family (TIGR04047; HMM-score: 31.9)
    colanic acid biosynthesis glycosyltransferase WcaL (TIGR04005; EC 2.4.-.-; HMM-score: 31.3)
    sucrose-phosphate synthase, putative, glycosyltransferase domain (TIGR02472; EC 2.4.1.14; HMM-score: 29.1)
    D-inositol-3-phosphate glycosyltransferase (TIGR03449; EC 2.4.1.250; HMM-score: 27.1)
    putative glycosyltransferase, TIGR04348 family (TIGR04348; EC 2.4.1.-; HMM-score: 23.4)
    Metabolism Energy metabolism Biosynthesis and degradation of polysaccharides glycogen synthase, Corynebacterium family (TIGR02149; HMM-score: 19.9)
    PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family (TIGR04063; EC 2.4.-.-; HMM-score: 18.9)
    Metabolism Energy metabolism Biosynthesis and degradation of polysaccharides sucrose synthase (TIGR02470; EC 2.4.1.13; HMM-score: 18.2)
  • TheSEED: see SPH_1869
  • PFAM:
    GT-B (CL0113) Glycos_transf_1; Glycosyl transferases group 1 (PF00534; HMM-score: 75.6)
    Glyco_trans_1_4; Glycosyl transferases group 1 (PF13692; HMM-score: 71.9)
    and 2 more
    Glyco_trans_1_2; Glycosyl transferases group 1 (PF13524; HMM-score: 13.8)
    SGNH_hydrolase (CL0264) Lipase_GDSL_2; GDSL-like Lipase/Acylhydrolase family (PF13472; HMM-score: 12.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9826
    • Cytoplasmic Membrane Score: 0.0062
    • Cell wall & surface Score: 0.002
    • Extracellular Score: 0.0092
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.010922
    • TAT(Tat/SPI): 0.000697
    • LIPO(Sec/SPII): 0.001397
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MTIYNINLGIGWASSGVEYAQAYRAGVFRKLNLSSKFIFTDMILADNIQHLTANIGFDDNQVIWLYNHFTDIKIAPTSVTVDDVLAYFGGEESHREKNGKVLRVFFFDQDKFVTCYLVDENKDLVQHAEYVFKGNLIRKDYFSYTRYCSEYFAPKDNVAVLYQRTFYNEDGTPVYDILMNQGKEEVYHFKDKIFYGKQAFVRAFMKSLNLNKSDLVILDRETGIGQVVFEEAQTAHLAVVVHAEHYSENATNEDYILWNNYYDYQFTNADKVDFFIVSTDRQNEVLQEQFAKYTQHQPKIVTIPVGSIDSLTDSSQGRKPFSLITASRLAKEKHIDWLVKAVIEAHKELPELTFDIYGSGGEDSLLREIIANHQAEDYIQLKGHAELSQIYSQYEVYLTASTSEGFGLTLMEAIGSGLPLIGFDVPYGNQTFIEDGQNGYLIPSSSDHVEDQIKQAYAAKICQLYQENRLEAMRAYSYQIAEGFLTKEILEKWKKTVEEVLHD

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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