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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 31-JAN-2014
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae JJA
- locus tag: SPJ_0685 [new locus tag: SPJ_RS03425 ]
- pan locus tag?: PNEUPAN001709000
- symbol: clpP
- pan gene symbol?: clpP
- synonym:
- product: Clp protease
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SPJ_0685 [new locus tag: SPJ_RS03425 ]
- symbol: clpP
- product: Clp protease
- replicon: chromosome
- strand: +
- coordinates: 661781..662371
- length: 591
- essential: unknown
⊟Accession numbers[edit | edit source]
- Location: CP000919 (661781..662371) NCBI
- BioCyc: see SPJ_RS03425
- MicrobesOnline: 7478954 MicrobesOnline
- PneumoBrowse for strain D39V: SPV_0650 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
- 1
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541ATGATTCCTGTAGTTATTGAACAAACAAGCCGTGGAGAACGTTCTTACGATATTTACTCA
CGTCTTCTCAAAGACCGCATCATTATGCTGACAGGTCCGGTTGAAGACAATATGGCTAAC
TCTGTTATTGCCCAATTGCTTTTCTTGGATGCCCAAGATAGTACAAAAGATATTTACCTT
TATGTCAATACACCAGGTGGTTCTGTTTCAGCTGGTTTGGCAATCGTAGATACCATGAAC
TTTATCAAGGCAGATGTCCAAACCATTGTTATGGGAATGGCTGCATCTATGGGAACAGTC
ATCGCATCAAGTGGAGCAAAAGGCAAACGTTTCATGCTTCCAAATGCTGAATACATGATT
CACCAACCAATGGGCGGTACAGGTGGTGGTACCCAACAAACTGATATGGCTATCGCTGCA
GAACACTTGCTCAAAACTCGTAATACCTTGGAAAAAATCTTGGCTGAAAATTCAGGTCAG
TCAATGGAAAAAGTCCATGCAGATGCAGAACGTGATAACTGGATGAGCGCCCAGGAAACA
CTTGAATATGGCTTTATTGATGAAATTATGGCCAACAATTCATTGAACTAA60
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591
⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SPJ_0685 [new locus tag: SPJ_RS03425 ]
- symbol: ClpP
- description: Clp protease
- length: 196
- theoretical pI: 4.49116
- theoretical MW: 21358.3
- GRAVY: -0.114796
⊟Function[edit | edit source]
- reaction: EC 3.4.21.92? ExPASyEndopeptidase Clp Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs)
- TIGRFAM: Protein fate Degradation of proteins, peptides, and glycopeptides ATP-dependent Clp endopeptidase, proteolytic subunit ClpP (TIGR00493; EC 3.4.21.92; HMM-score: 285.8)and 2 moreProtein fate Degradation of proteins, peptides, and glycopeptides signal peptide peptidase SppA, 36K type (TIGR00706; EC 3.4.-.-; HMM-score: 22.9)Protein fate Degradation of proteins, peptides, and glycopeptides signal peptide peptidase SppA, 67K type (TIGR00705; EC 3.4.-.-; HMM-score: 21.5)
- TheSEED :
- ATP-dependent Clp protease proteolytic subunit ClpP (EC 3.4.21.92)
Protein Metabolism Protein degradation Proteolysis in bacteria, ATP-dependent ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)and 1 more - PFAM: ClpP_crotonase (CL0127) CLP_protease; Clp protease (PF00574; HMM-score: 265.6)and 1 moreSDH_sah; Serine dehydrogenase proteinase (PF01972; HMM-score: 17.2)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 9.97
- Cytoplasmic Membrane Score: 0
- Cellwall Score: 0.01
- Extracellular Score: 0.02
- Internal Helices: 0
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.003116
- TAT(Tat/SPI): 0.000418
- LIPO(Sec/SPII): 0.000546
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDSTKDIYLYVNTPGGSVSAGLAIVDTMNFIKADVQTIVMGMAASMGTVIASSGAKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRNTLEKILAENSGQSMEKVHADAERDNWMSAQETLEYGFIDEIMANNSLN
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- regulator: CtsR* (repression) regulon
CtsR* (TF) important in Heat shock response; RegPrecise
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_0650 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You are kindly invited to share additional interesting facts.
⊟Literature[edit | edit source]
⊟References[edit | edit source]
⊟Relevant publications[edit | edit source]
Ju Cao, Yi Gong, ShanShan Dong, Liping Zhang, Xaiofei Lai, Xuemei Zhang, Yibing Yin
Pneumococcal ClpP modulates the maturation and activation of human dendritic cells: implications for pneumococcal infections.
J Leukoc Biol: 2013, 93(5);737-49
[PubMed:23381472] [WorldCat.org] [DOI] (I p)