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JJA
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NU83127
serotype 4
OXC141
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SPN034156
serotype 3
SPN034183
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SPN994038
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SPN994039
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SPNA45
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ST556
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TCH8431/19A
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serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae JJA
  • locus tag: SPJ_0834 [new locus tag: SPJ_RS04160 ]
  • pan locus tag?: PNEUPAN001889000
  • symbol: SPJ_0834
  • pan gene symbol?: argR2
  • synonym:
  • product: arginine repressor

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPJ_0834 [new locus tag: SPJ_RS04160 ]
  • symbol: SPJ_0834
  • product: arginine repressor
  • replicon: chromosome
  • strand: -
  • coordinates: 800649..801119
  • length: 471
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    ATGAATAAATCAGAACACCGCCACCAACTTATACGCGCTCTTATCACAAAAAACAAGATT
    CATACACAGGCTGAGTTGCAAGCCCTTCTTGCTGAGAACGACATTCAAGTAACCCAGGCA
    ACCCTCTCACGCGACATCAAAAATATGAACCTATCAAAAGTCCGCGAAGAAGATAGCGCT
    TATTATGTTCTTAACAATGGTTCCATCTCAAAATGGGAAAAACGTCTCGAACTCTACATG
    GAAGACGCCCTTGTCTGGATGCGCCCAGTTCAACACCAAGTCCTACTAAAAACCCTTCCT
    GGACTGGCTCAATCCTTTGGTTCTATCATTGATACTTTGAGCTTCCCTGACGCTATCGCT
    ACCCTTTGTGGTAATGATGTCTGTCTTATCATCTGTGAAGATGCAGATACTGCTCAAAAG
    TGCTTTGAAGAACTGAAAAAATTCGCCCCACCATTTTTCTTTGAAGAATAA
    60
    120
    180
    240
    300
    360
    420
    471

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPJ_0834 [new locus tag: SPJ_RS04160 ]
  • symbol: SPJ_0834
  • description: arginine repressor
  • length: 156
  • theoretical pI: 5.26582
  • theoretical MW: 17842.4
  • GRAVY: -0.228205

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Amino acid biosynthesis Glutamate family arginine repressor (TIGR01529; HMM-score: 119.5)
    Signal transduction Regulatory functions DNA interactions arginine repressor (TIGR01529; HMM-score: 119.5)
  • TheSEED  :
    • Arginine pathway regulatory protein ArgR, repressor of arg regulon
    Amino Acids and Derivatives Arginine; urea cycle, polyamines Arginine and Ornithine Degradation  Arginine pathway regulatory protein ArgR, repressor of arg regulon
    and 1 more
    Amino Acids and Derivatives Arginine; urea cycle, polyamines Arginine Deiminase Pathway  Arginine pathway regulatory protein ArgR, repressor of arg regulon
  • PFAM:
    HTH (CL0123) Arg_repressor; Arginine repressor, DNA binding domain (PF01316; HMM-score: 79.7)
    no clan defined Arg_repressor_C; Arginine repressor, C-terminal domain (PF02863; HMM-score: 63.8)
    and 6 more
    SMC_hinge; SMC proteins Flexible Hinge Domain (PF06470; HMM-score: 19.7)
    DUF3135; Protein of unknown function (DUF3135) (PF11333; HMM-score: 13.8)
    NADP_Rossmann (CL0063) PRMT5; PRMT5 arginine-N-methyltransferase (PF05185; HMM-score: 13.6)
    RRM (CL0221) SET_assoc; Histone lysine methyltransferase SET associated (PF11767; HMM-score: 13.1)
    HTH (CL0123) HTH_Tnp_Tc3_2; Transposase (PF01498; HMM-score: 12.8)
    no clan defined DUF3427; Domain of unknown function (DUF3427) (PF11907; HMM-score: 12.7)

⊟Structure, modifications & cofactors[edit | edit source]

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.67
    • Cytoplasmic Membrane Score: 0.01
    • Cellwall Score: 0.15
    • Extracellular Score: 0.17
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.014337
    • TAT(Tat/SPI): 0.002809
    • LIPO(Sec/SPII): 0.001658
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MNKSEHRHQLIRALITKNKIHTQAELQALLAENDIQVTQATLSRDIKNMNLSKVREEDSAYYVLNNGSISKWEKRLELYMEDALVWMRPVQHQVLLKTLPGLAQSFGSIIDTLSFPDAIATLCGNDVCLIICEDADTAQKCFEELKKFAPPFFFEE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Christian Schulz, Philipp Gierok, Lothar Petruschka, Michael Lalk, Ulrike Mäder, Sven Hammerschmidt
Regulation of the arginine deiminase system by ArgR2 interferes with arginine metabolism and fitness of Streptococcus pneumoniae.
mBio: 2014, 5(6);
[PubMed:25538192] [WorldCat.org] [DOI] (I e)

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