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serotype 4
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serotype 6B
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serotype 6A
70585
serotype 5
A026
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AP200
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CGSP14
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Hu15
serotype 19A
Hu17
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INV104
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INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
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SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae JJA
  • locus tag: SPJ_2129 [new locus tag: SPJ_RS10565 ]
  • pan locus tag?: PNEUPAN003714000
  • symbol: SPJ_2129
  • pan gene symbol?: malX
  • synonym:
  • product: maltose/maltodextrin-binding protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPJ_2129 [new locus tag: SPJ_RS10565 ]
  • symbol: SPJ_2129
  • product: maltose/maltodextrin-binding protein
  • replicon: chromosome
  • strand: +
  • coordinates: 1980511..1981782
  • length: 1272
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    ATGTCATCTAAATTTATGAAGAGCACTGCGGTGCTTGGAACTGTTACACTTGCTAGCTTG
    CTTTTGGTAGCTTGCGGAAGCAAAACTGCTGATAAGCCTGCTGATTCTGGTTCATCTGAA
    GTCAAAGAACTCACTGTATATGTAGACGAGGGATATAAGAGCTATATTGAAGAGGTTGCT
    AAAGCTTATGAAAAAGAAGCTGGAGTAAAAGTCACTCTTAAAACTGGTGATGCTCTAGGA
    GGTCTTGATAAACTTTCTCTTGACAACCAATCTGGTAATGTCCCTGATGTTATGATGGCT
    CCATACGACCGTGTAGGTAGCCTTGGTTCTGACGGACAACTTTCAGAAGTGAAATTGAGC
    GATGGTGCTAAAACAGACGACACAACTAAATCTCTTGTAACAGCTGCTAATGGTAAAGTT
    TACGGTGCTCCTGCCGTTATCGAGTCACTTGTTATGTACTACAACAAAGACTTGGTGAAA
    GATGCTCCAAAAACATTTGCTGACTTGGAAAACCTTGCTAAAGATAGCAAATACGCATTC
    GCTGGTGAAGATGGTAAAACTACTGCCTTCCTAGCTGACTGGACAAACTTCTACTATACA
    TATGGACTTCTTGCCGGTAACGGTGCTTACGTCTTTGGCCAAAACGGTAAAGACGCTAAA
    GACATCGGTCTTGCAAACGACGGTTCTATCGTAGGTATCAACTACGCTAAATCTTGGTAC
    GAAAAATGGCCTAAAGGTATGCAAGATACAGAAGGTGCTGGAAACTTAATCCAAACTCAA
    TTCCAAGAAGGTAAAACAGCTGCTATCATCGACGGACCTTGGAAAGCTCAAGCCTTTAAA
    GATGCTAAAGTAAACTACGGAGTTGCAACTATCCCAACTCTTCCAAATGGAAAAGAATAT
    GCTGCATTCGGTGGTGGTAAAGCTTGGGTCATTCCTCAAGCCGTTAAGAACCTTGAAGCT
    TCTCAAAAATTTGTAGACTTCCTTGTTGCAACTGAACAACAAAAAGTATTATATGATAAG
    ACTAACGAAATCCCAGCTAATACTGAGGCTCGTTCATACGCTGAAGGTAAAAACGATGAG
    TTGACAACAGCTGTTATCAAACAGTTCAAGAACACTCAACCACTGCCAAACATCTCTCAA
    ATGTCTGCAGTTTGGGATCCAGCGAAAAATATGCTCTTTGATGCTGTAAGTGGTCAAAAA
    GATGCTAAAACAGCTGCTAACGATGCTGTAACATTGATCAAAGAAACAATCAAACAAAAA
    TTTGGTGAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1272

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPJ_2129 [new locus tag: SPJ_RS10565 ]
  • symbol: SPJ_2129
  • description: maltose/maltodextrin-binding protein
  • length: 423
  • theoretical pI: 4.82456
  • theoretical MW: 45394.8
  • GRAVY: -0.347991

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids carbohydrate ABC transporter substrate-binding protein, CPR_0540 family (TIGR03850; HMM-score: 57.7)
    and 1 more
    2-aminoethylphosphonate ABC transporter, 2-aminoethylphosphonate binding protein (TIGR03227; HMM-score: 29.9)
  • TheSEED  :
    • Maltose/maltodextrin ABC transporter, substrate binding periplasmic protein MalE
    Carbohydrates Di- and oligosaccharides Maltose and Maltodextrin Utilization  Maltose/maltodextrin ABC transporter, substrate binding periplasmic protein MalE
    and 2 more
    Carbohydrates Polysaccharides Alpha-Amylase locus in Streptocococcus  Maltose/maltodextrin ABC transporter, substrate binding periplasmic protein MalE
    Motility and Chemotaxis Motility and Chemotaxis - no subcategory Bacterial Chemotaxis  Maltose/maltodextrin ABC transporter, substrate binding periplasmic protein MalE
  • PFAM:
    PBP (CL0177) SBP_bac_8; Bacterial extracellular solute-binding protein (PF13416; HMM-score: 135)
    SBP_bac_1; Bacterial extracellular solute-binding protein (PF01547; HMM-score: 122.6)
    and 3 more
    SBP_bac_11; Bacterial extracellular solute-binding protein (PF13531; HMM-score: 31.6)
    SBP_bac_6; Bacterial extracellular solute-binding protein (PF13343; HMM-score: 24)
    TPR (CL0020) RAI16-like; Retinoic acid induced 16-like protein (PF10257; HMM-score: 10.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helix: 1
  • SignalP: Signal peptide LIPO(Sec/SPII) length 24 aa
    • SP(Sec/SPI): 0.001711
    • TAT(Tat/SPI): 0.000181
    • LIPO(Sec/SPII): 0.997856
    • Cleavage Site: CS pos: 24-25. LVA-CG. Pr: 0.9974
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MSSKFMKSTAVLGTVTLASLLLVACGSKTADKPADSGSSEVKELTVYVDEGYKSYIEEVAKAYEKEAGVKVTLKTGDALGGLDKLSLDNQSGNVPDVMMAPYDRVGSLGSDGQLSEVKLSDGAKTDDTTKSLVTAANGKVYGAPAVIESLVMYYNKDLVKDAPKTFADLENLAKDSKYAFAGEDGKTTAFLADWTNFYYTYGLLAGNGAYVFGQNGKDAKDIGLANDGSIVGINYAKSWYEKWPKGMQDTEGAGNLIQTQFQEGKTAAIIDGPWKAQAFKDAKVNYGVATIPTLPNGKEYAAFGGGKAWVIPQAVKNLEASQKFVDFLVATEQQKVLYDKTNEIPANTEARSYAEGKNDELTTAVIKQFKNTQPLPNISQMSAVWDPAKNMLFDAVSGQKDAKTAANDAVTLIKETIKQKFGE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulators: MalR* (repression) regulon, CcpA regulon
    MalR*(TF)important in Maltose utilization, Maltodextrin utilization; RegPrecise 
    CcpA(TF)important in Global catabolite repression; RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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